Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770607980> ?p ?o ?g. }
- W2770607980 endingPage "45" @default.
- W2770607980 startingPage "32" @default.
- W2770607980 abstract "The incidence of metabolic disorders like type 2 diabetes and obesity continues to increase. In addition to the well-known contributors to these disorders, such as food intake and sedentary lifestyle, recent research in the exposure science discipline provides evidence that exposure to endocrine-disrupting chemicals like bisphenol A and phthalates via multiple routes (e.g., food, drink, skin contact) also contribute to the increased risk of metabolic disorders. Endocrine-disrupting chemicals (EDCs) can disrupt any aspect of hormone action. It is becoming increasingly clear that EDCs not only affect endocrine function but also adversely affect immune system function. In this review, we focus on human, animal, and in vitro studies that demonstrate EDC exposure induces dysfunction of the immune system, which, in turn, has detrimental effects on metabolic health. These findings highlight how the immune system is emerging as a novel player by which EDCs may mediate their effects on metabolic health. We also discuss studies highlighting mechanisms by which EDCs affect the immune system. Finally, we consider that a better understanding of the immunomodulatory roles of EDCs will provide clues to enhance metabolic function and contribute toward the long-term goal of reducing the burden of environmentally induced diabetes and obesity." @default.
- W2770607980 created "2017-12-04" @default.
- W2770607980 creator A5077604020 @default.
- W2770607980 creator A5084373557 @default.
- W2770607980 creator A5088462613 @default.
- W2770607980 date "2017-11-14" @default.
- W2770607980 modified "2023-10-16" @default.
- W2770607980 title "Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health" @default.
- W2770607980 cites W1151108630 @default.
- W2770607980 cites W1232063659 @default.
- W2770607980 cites W1480729244 @default.
- W2770607980 cites W1561041814 @default.
- W2770607980 cites W1584483067 @default.
- W2770607980 cites W1863724130 @default.
- W2770607980 cites W1912117534 @default.
- W2770607980 cites W1958756232 @default.
- W2770607980 cites W1965011825 @default.
- W2770607980 cites W1966336914 @default.
- W2770607980 cites W1967896870 @default.
- W2770607980 cites W1968179768 @default.
- W2770607980 cites W1968705853 @default.
- W2770607980 cites W1971556971 @default.
- W2770607980 cites W1971641550 @default.
- W2770607980 cites W1977726417 @default.
- W2770607980 cites W1978961133 @default.
- W2770607980 cites W1981967540 @default.
- W2770607980 cites W1988609641 @default.
- W2770607980 cites W1992346878 @default.
- W2770607980 cites W1997490166 @default.
- W2770607980 cites W2001710713 @default.
- W2770607980 cites W2003114423 @default.
- W2770607980 cites W2003551375 @default.
- W2770607980 cites W2007980175 @default.
- W2770607980 cites W2009004909 @default.
- W2770607980 cites W2015289974 @default.
- W2770607980 cites W2017829700 @default.
- W2770607980 cites W2020362104 @default.
- W2770607980 cites W2021824780 @default.
- W2770607980 cites W2023256644 @default.
- W2770607980 cites W2024378513 @default.
- W2770607980 cites W2027298104 @default.
- W2770607980 cites W2027643441 @default.
- W2770607980 cites W2028071281 @default.
- W2770607980 cites W2028180178 @default.
- W2770607980 cites W2032230795 @default.
- W2770607980 cites W2033211255 @default.
- W2770607980 cites W2041136224 @default.
- W2770607980 cites W2042615824 @default.
- W2770607980 cites W2047142193 @default.
- W2770607980 cites W2047523002 @default.
- W2770607980 cites W2048432175 @default.
- W2770607980 cites W2050449334 @default.
- W2770607980 cites W2052450630 @default.
- W2770607980 cites W2054931962 @default.
- W2770607980 cites W2056036338 @default.
- W2770607980 cites W2057598257 @default.
- W2770607980 cites W2057920217 @default.
- W2770607980 cites W2060658973 @default.
- W2770607980 cites W2061459507 @default.
- W2770607980 cites W2067248150 @default.
- W2770607980 cites W2068389617 @default.
- W2770607980 cites W2073116679 @default.
- W2770607980 cites W2074658648 @default.
- W2770607980 cites W2076310317 @default.
- W2770607980 cites W2076995497 @default.
- W2770607980 cites W2079217745 @default.
- W2770607980 cites W2079642848 @default.
- W2770607980 cites W2080755877 @default.
- W2770607980 cites W2085622490 @default.
- W2770607980 cites W2088940658 @default.
- W2770607980 cites W2089628522 @default.
- W2770607980 cites W2095511853 @default.
- W2770607980 cites W2095646018 @default.
- W2770607980 cites W2096264334 @default.
- W2770607980 cites W2104890139 @default.
- W2770607980 cites W2106079757 @default.
- W2770607980 cites W2108860104 @default.
- W2770607980 cites W2108900261 @default.
- W2770607980 cites W2110569929 @default.
- W2770607980 cites W2121182926 @default.
- W2770607980 cites W2125058279 @default.
- W2770607980 cites W2125320016 @default.
- W2770607980 cites W2125517561 @default.
- W2770607980 cites W2126384811 @default.
- W2770607980 cites W2126840560 @default.
- W2770607980 cites W2128721675 @default.
- W2770607980 cites W2129917444 @default.
- W2770607980 cites W2134880599 @default.
- W2770607980 cites W2134962283 @default.
- W2770607980 cites W2135989088 @default.
- W2770607980 cites W2139341806 @default.
- W2770607980 cites W2139941832 @default.
- W2770607980 cites W2140321480 @default.
- W2770607980 cites W2140832481 @default.
- W2770607980 cites W2144275312 @default.
- W2770607980 cites W2144871388 @default.
- W2770607980 cites W2147827078 @default.
- W2770607980 cites W2148619299 @default.