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- W2770616154 endingPage "120" @default.
- W2770616154 startingPage "111" @default.
- W2770616154 abstract "Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent years, it has become clear that signal transduction in sperm is not a continuum, but rather organized in subcellular domains, e.g. the sperm head and the sperm flagellum, with the latter being further separated into the midpiece, principal piece, and endpiece. To understand the underlying signaling pathways controlling sperm function in more detail, experimental approaches are needed that allow to study sperm signaling with spatial and temporal precision. Here, we will give a comprehensive overview on cAMP signaling in mammalian sperm, describing the molecular players involved in these pathways and the sperm functions that are controlled by cAMP. Furthermore, we will highlight recent advances in analyzing and manipulating sperm signaling with spatio-temporal precision using light." @default.
- W2770616154 created "2017-12-04" @default.
- W2770616154 creator A5002976896 @default.
- W2770616154 creator A5040921993 @default.
- W2770616154 creator A5062519728 @default.
- W2770616154 creator A5077869340 @default.
- W2770616154 date "2018-06-01" @default.
- W2770616154 modified "2023-09-24" @default.
- W2770616154 title "Shedding light on the role of cAMP in mammalian sperm physiology" @default.
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