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- W2770619281 abstract "The pluripotency of embryonic stem cells (ESCs) relies on appropriate responsiveness to developmental cues. Promoter-proximal pausing of RNA polymerase II (Pol II) has been suggested to play a role in keeping genes poised for future activation. To identify the role of Pol II pausing in regulating ESC pluripotency, we have generated mouse ESCs carrying a mutation in the pause-inducing factor SPT5. Genomic studies reveal genome-wide reduction of paused Pol II caused by mutant SPT5 and further identify a tight correlation between pausing-mediated transcription effect and local chromatin environment. Functionally, this pausing-deficient SPT5 disrupts ESC differentiation upon removal of self-renewal signals. Thus, our study uncovers an important role of Pol II pausing in regulating ESC differentiation and suggests a model that Pol II pausing coordinates with epigenetic modification to influence transcription during mESC differentiation." @default.
- W2770619281 created "2017-12-04" @default.
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- W2770619281 date "2017-12-01" @default.
- W2770619281 modified "2023-10-13" @default.
- W2770619281 title "Transcription pausing regulates mouse embryonic stem cell differentiation" @default.
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- W2770619281 doi "https://doi.org/10.1016/j.scr.2017.11.012" @default.
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