FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770619489> ?p ?o ?g. }

• W2770619489 endingPage "24" @default.
• W2770619489 startingPage "18" @default.
• W2770619489 abstract "Obesity is independently associated with disturbances in lipid and lipoprotein metabolism, oxidative stress, and is a well-established independent risk factor for cardiovascular diseases (CVD). Human paraoxonase 1 (PON1) is a pleotropic high-density lipoprotein (HDL)-associated enzyme with antioxidant and anti-inflammatory proprieties that have been suggested to contribute to the athero-protective function of the lipoprotein. The aim of this study was to investigate whether obesity is associated with PON1 activity and whether this association is influenced by oxidative stress, inflammation and HDL cholesterol (HDL-C) concentration. The promiscuous activities, arylesterase and paraoxonase, and the putative physiological activity, lactonase, of PON1 were assessed in the serum of 214 obese and severely obese, 101 overweight and 129 normal-weight women. Levels of high-sensitivity C-reactive protein (hs-CRP), hydroperoxides (by-products of lipid oxidative damage) and lipid profiles were also evaluated. Arylesterase activity was the only activity that significantly differed across the groups (ANOVA, p < .01), with the greatest decrease observed in individuals with body mass index (BMI) > 40 kg/m2 compared to controls (p < .001). This activity was also inversely, although weakly (r = −0.160, p < .001) correlated with the BMI, and the association was independent of age and levels of oxidative stress and inflammation, but not of HDL-C concentration. In conclusion, our results suggest that the apparent obesity-associated decrement of PON1 activity might simply reflect the decrease in concentration of its plasmatic carrier." @default.
• W2770619489 created "2017-12-04" @default.
• W2770619489 creator A5001521177 @default.
• W2770619489 creator A5024537814 @default.
• W2770619489 creator A5026466905 @default.
• W2770619489 creator A5029455714 @default.
• W2770619489 creator A5030471925 @default.
• W2770619489 creator A5033091395 @default.
• W2770619489 creator A5035013588 @default.
• W2770619489 creator A5039462503 @default.
• W2770619489 creator A5061103969 @default.
• W2770619489 creator A5069021176 @default.
• W2770619489 creator A5079843993 @default.
• W2770619489 creator A5081878436 @default.
• W2770619489 creator A5088517023 @default.
• W2770619489 date "2017-11-23" @default.
• W2770619489 modified "2023-09-26" @default.
• W2770619489 title "Paraoxonase, arylesterase and lactonase activities of paraoxonase-1 (PON1) in obese and severely obese women" @default.
• W2770619489 cites W1551234954 @default.
• W2770619489 cites W1869060308 @default.
• W2770619489 cites W1925587073 @default.
• W2770619489 cites W1964917637 @default.
• W2770619489 cites W1966902937 @default.
• W2770619489 cites W1978064757 @default.
• W2770619489 cites W1985954107 @default.
• W2770619489 cites W1994968752 @default.
• W2770619489 cites W1995703529 @default.
• W2770619489 cites W1998927777 @default.
• W2770619489 cites W1999056808 @default.
• W2770619489 cites W2000847748 @default.
• W2770619489 cites W2010178137 @default.
• W2770619489 cites W2025679035 @default.
• W2770619489 cites W2026999474 @default.
• W2770619489 cites W2037373696 @default.
• W2770619489 cites W2045124367 @default.
• W2770619489 cites W2059228589 @default.
• W2770619489 cites W2063584976 @default.
• W2770619489 cites W2064198078 @default.
• W2770619489 cites W2068644814 @default.
• W2770619489 cites W2081995399 @default.
• W2770619489 cites W2085222803 @default.
• W2770619489 cites W2085566853 @default.
• W2770619489 cites W2088146532 @default.
• W2770619489 cites W2088720117 @default.
• W2770619489 cites W2096664466 @default.
• W2770619489 cites W2097174145 @default.
• W2770619489 cites W2113480633 @default.
• W2770619489 cites W2118969396 @default.
• W2770619489 cites W2125578916 @default.
• W2770619489 cites W2131398405 @default.
• W2770619489 cites W2133990668 @default.
• W2770619489 cites W2147514283 @default.
• W2770619489 cites W2154168373 @default.
• W2770619489 cites W2157157967 @default.
• W2770619489 cites W2158953418 @default.
• W2770619489 cites W2159959895 @default.
• W2770619489 cites W2161414810 @default.
• W2770619489 cites W2162946088 @default.
• W2770619489 cites W2164259487 @default.
• W2770619489 cites W2166691340 @default.
• W2770619489 cites W2170466777 @default.
• W2770619489 cites W2196726006 @default.
• W2770619489 cites W2233978156 @default.
• W2770619489 cites W2253642317 @default.
• W2770619489 cites W2292946576 @default.
• W2770619489 cites W2433619092 @default.
• W2770619489 cites W2480489829 @default.
• W2770619489 cites W2136195672 @default.
• W2770619489 doi "https://doi.org/10.1080/00365513.2017.1405274" @default.
• W2770619489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29168398" @default.
• W2770619489 hasPublicationYear "2017" @default.
• W2770619489 type Work @default.
• W2770619489 sameAs 2770619489 @default.
• W2770619489 citedByCount "24" @default.
• W2770619489 countsByYear W27706194892018 @default.
• W2770619489 countsByYear W27706194892019 @default.
• W2770619489 countsByYear W27706194892020 @default.
• W2770619489 countsByYear W27706194892021 @default.
• W2770619489 countsByYear W27706194892022 @default.
• W2770619489 countsByYear W27706194892023 @default.
• W2770619489 crossrefType "journal-article" @default.
• W2770619489 hasAuthorship W2770619489A5001521177 @default.
• W2770619489 hasAuthorship W2770619489A5024537814 @default.
• W2770619489 hasAuthorship W2770619489A5026466905 @default.
• W2770619489 hasAuthorship W2770619489A5029455714 @default.
• W2770619489 hasAuthorship W2770619489A5030471925 @default.
• W2770619489 hasAuthorship W2770619489A5033091395 @default.
• W2770619489 hasAuthorship W2770619489A5035013588 @default.
• W2770619489 hasAuthorship W2770619489A5039462503 @default.
• W2770619489 hasAuthorship W2770619489A5061103969 @default.
• W2770619489 hasAuthorship W2770619489A5069021176 @default.
• W2770619489 hasAuthorship W2770619489A5079843993 @default.
• W2770619489 hasAuthorship W2770619489A5081878436 @default.
• W2770619489 hasAuthorship W2770619489A5088517023 @default.
• W2770619489 hasBestOaLocation W27706194892 @default.
• W2770619489 hasConcept C104317684 @default.
• W2770619489 hasConcept C126322002 @default.
• W2770619489 hasConcept C134018914 @default.

• next