Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770636223> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2770636223 endingPage "211.3" @default.
- W2770636223 startingPage "211.3" @default.
- W2770636223 abstract "Abstract Little is known about how the immune system impacts human colorectal cancer invasiveness and stemness. Here we detected interleukin-22 (IL-22) in patient colorectal cancer tissues that was produced predominantly by CD4+ T cells. In a mouse model, migration of these cells into the colon cancer microenvironment required the chemokine receptor CCR6 and its ligand CCL20. IL-22 acted on cancer cells to promote activation of the transcription factor STAT3 and expression of the histone 3 lysine 79 (H3K79) methytransferase DOT1L. The DOT1L complex induced the core stem cell genes NANOG, SOX2, and Pou5F1, resulting in increased cancer stemness and tumorigenic potential. Furthermore, high DOT1L expression and H3K79me2 in colorectal cancer tissues was a predictor of poor patient survival. Thus, IL-22+ cells promote colon cancer stemness via regulation of stemness genes that negatively affects patient outcome. Efforts to target this network might be a strategy in treating colorectal cancer patients." @default.
- W2770636223 created "2017-12-04" @default.
- W2770636223 creator A5001755762 @default.
- W2770636223 creator A5005093063 @default.
- W2770636223 creator A5005496208 @default.
- W2770636223 creator A5006072731 @default.
- W2770636223 creator A5018902521 @default.
- W2770636223 creator A5032215937 @default.
- W2770636223 creator A5044332371 @default.
- W2770636223 creator A5049346665 @default.
- W2770636223 creator A5055671579 @default.
- W2770636223 creator A5066048991 @default.
- W2770636223 creator A5066089503 @default.
- W2770636223 creator A5070857081 @default.
- W2770636223 creator A5086113297 @default.
- W2770636223 creator A5088147590 @default.
- W2770636223 date "2015-05-01" @default.
- W2770636223 modified "2023-10-17" @default.
- W2770636223 title "IL-22+CD4+ T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L (TUM10P.1022)" @default.
- W2770636223 doi "https://doi.org/10.4049/jimmunol.194.supp.211.3" @default.
- W2770636223 hasPublicationYear "2015" @default.
- W2770636223 type Work @default.
- W2770636223 sameAs 2770636223 @default.
- W2770636223 citedByCount "0" @default.
- W2770636223 crossrefType "journal-article" @default.
- W2770636223 hasAuthorship W2770636223A5001755762 @default.
- W2770636223 hasAuthorship W2770636223A5005093063 @default.
- W2770636223 hasAuthorship W2770636223A5005496208 @default.
- W2770636223 hasAuthorship W2770636223A5006072731 @default.
- W2770636223 hasAuthorship W2770636223A5018902521 @default.
- W2770636223 hasAuthorship W2770636223A5032215937 @default.
- W2770636223 hasAuthorship W2770636223A5044332371 @default.
- W2770636223 hasAuthorship W2770636223A5049346665 @default.
- W2770636223 hasAuthorship W2770636223A5055671579 @default.
- W2770636223 hasAuthorship W2770636223A5066048991 @default.
- W2770636223 hasAuthorship W2770636223A5066089503 @default.
- W2770636223 hasAuthorship W2770636223A5070857081 @default.
- W2770636223 hasAuthorship W2770636223A5086113297 @default.
- W2770636223 hasAuthorship W2770636223A5088147590 @default.
- W2770636223 hasConcept C104317684 @default.
- W2770636223 hasConcept C107459253 @default.
- W2770636223 hasConcept C121608353 @default.
- W2770636223 hasConcept C145103041 @default.
- W2770636223 hasConcept C203014093 @default.
- W2770636223 hasConcept C207701140 @default.
- W2770636223 hasConcept C2776107976 @default.
- W2770636223 hasConcept C2777933648 @default.
- W2770636223 hasConcept C2778923194 @default.
- W2770636223 hasConcept C28328180 @default.
- W2770636223 hasConcept C502942594 @default.
- W2770636223 hasConcept C526805850 @default.
- W2770636223 hasConcept C54355233 @default.
- W2770636223 hasConcept C55427017 @default.
- W2770636223 hasConcept C62478195 @default.
- W2770636223 hasConcept C86339819 @default.
- W2770636223 hasConcept C86803240 @default.
- W2770636223 hasConcept C8891405 @default.
- W2770636223 hasConcept C95444343 @default.
- W2770636223 hasConcept C96232424 @default.
- W2770636223 hasConceptScore W2770636223C104317684 @default.
- W2770636223 hasConceptScore W2770636223C107459253 @default.
- W2770636223 hasConceptScore W2770636223C121608353 @default.
- W2770636223 hasConceptScore W2770636223C145103041 @default.
- W2770636223 hasConceptScore W2770636223C203014093 @default.
- W2770636223 hasConceptScore W2770636223C207701140 @default.
- W2770636223 hasConceptScore W2770636223C2776107976 @default.
- W2770636223 hasConceptScore W2770636223C2777933648 @default.
- W2770636223 hasConceptScore W2770636223C2778923194 @default.
- W2770636223 hasConceptScore W2770636223C28328180 @default.
- W2770636223 hasConceptScore W2770636223C502942594 @default.
- W2770636223 hasConceptScore W2770636223C526805850 @default.
- W2770636223 hasConceptScore W2770636223C54355233 @default.
- W2770636223 hasConceptScore W2770636223C55427017 @default.
- W2770636223 hasConceptScore W2770636223C62478195 @default.
- W2770636223 hasConceptScore W2770636223C86339819 @default.
- W2770636223 hasConceptScore W2770636223C86803240 @default.
- W2770636223 hasConceptScore W2770636223C8891405 @default.
- W2770636223 hasConceptScore W2770636223C95444343 @default.
- W2770636223 hasConceptScore W2770636223C96232424 @default.
- W2770636223 hasIssue "1_Supplement" @default.
- W2770636223 hasLocation W27706362231 @default.
- W2770636223 hasOpenAccess W2770636223 @default.
- W2770636223 hasPrimaryLocation W27706362231 @default.
- W2770636223 hasRelatedWork W1987678124 @default.
- W2770636223 hasRelatedWork W2069968873 @default.
- W2770636223 hasRelatedWork W2131005225 @default.
- W2770636223 hasRelatedWork W2182257602 @default.
- W2770636223 hasRelatedWork W2465295184 @default.
- W2770636223 hasRelatedWork W2901395140 @default.
- W2770636223 hasRelatedWork W2964393626 @default.
- W2770636223 hasRelatedWork W3108889493 @default.
- W2770636223 hasRelatedWork W3139267466 @default.
- W2770636223 hasRelatedWork W4293548575 @default.
- W2770636223 hasVolume "194" @default.
- W2770636223 isParatext "false" @default.
- W2770636223 isRetracted "false" @default.
- W2770636223 magId "2770636223" @default.
- W2770636223 workType "article" @default.