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- W2770637178 endingPage "e8583" @default.
- W2770637178 startingPage "e8583" @default.
- W2770637178 abstract "Background: Long noncoding RNAs (LncRNAs) are involved in the development and progression of various cancers. Accumulating evidences indicated that expression of lncRNAs was related to the prognosis of tumors. Methods: Here, 3 well-known lncRNAs associated with cancer were gathered to prove the potential role of lncRNAs as novel predictors of survival in human cancer. This meta-analysis collected all eligible studies about TUG1, SPRY4-IT1, and HULC and explored the relationship between lncRNAs expression and lymph node metastasis (LNM) or overall survival (OS). A comprehensive, computerized literature search was undertaken by using PubMed, EMBASE, Cochrane Library, and Web of Science (up to October 10, 2017). Strength of association between 3 lncRNAs and cancer prognosis was assessed by computing the hazard ratios (HR) with its corresponding 95% confidence interval (CI). According to the inclusion and exclusion criteria, respectively, 10, 9, and 7 studies of 3 lncRNAs were included in this meta-analysis. Results: In the current meta-analysis, it could be concluded that the expression of these 3 lncRNAs in tumor tissues is not a direct evidence of LNM. In general, there was a significant negative correlation between TUG1 levels and OS time (pooled HR 1.54, 95% CI 1.06–2.24), SPRY4-IT1 levels and OS time (pooled HR 2.12, 95% CI 1.58–2.86) and HULC levels and OS time (pooled HR 2.10, 95% CI 1.18–3.73). It could be revealed from the result that high level expression of these 3 lncRNAs might be correlated with a bad prognosis. Conclusions: In conclusion, the current meta-analysis demonstrated that TUG1, SPRY4-IT1, and HULC might serve as a moderate predictor of survival in human cancer." @default.
- W2770637178 created "2017-12-04" @default.
- W2770637178 creator A5006926548 @default.
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- W2770637178 creator A5065608852 @default.
- W2770637178 creator A5068016508 @default.
- W2770637178 creator A5084906802 @default.
- W2770637178 date "2017-11-01" @default.
- W2770637178 modified "2023-09-26" @default.
- W2770637178 title "TUG1, SPRY4-IT1, and HULC as valuable prognostic biomarkers of survival in cancer" @default.
- W2770637178 cites W1507361162 @default.
- W2770637178 cites W1606879372 @default.
- W2770637178 cites W1627852701 @default.
- W2770637178 cites W165825322 @default.
- W2770637178 cites W1853602163 @default.
- W2770637178 cites W1868736398 @default.
- W2770637178 cites W1904765960 @default.
- W2770637178 cites W1960377328 @default.
- W2770637178 cites W1966249816 @default.
- W2770637178 cites W1966397536 @default.
- W2770637178 cites W1968711495 @default.
- W2770637178 cites W1983335031 @default.
- W2770637178 cites W1988447508 @default.
- W2770637178 cites W1989904037 @default.
- W2770637178 cites W1998392635 @default.
- W2770637178 cites W1999616263 @default.
- W2770637178 cites W2006556963 @default.
- W2770637178 cites W2020016182 @default.
- W2770637178 cites W2024846717 @default.
- W2770637178 cites W2033776879 @default.
- W2770637178 cites W2035365585 @default.
- W2770637178 cites W2053220435 @default.
- W2770637178 cites W2053453206 @default.
- W2770637178 cites W2059191987 @default.
- W2770637178 cites W2060430981 @default.
- W2770637178 cites W2062296158 @default.
- W2770637178 cites W2066035908 @default.
- W2770637178 cites W2075642745 @default.
- W2770637178 cites W2077663753 @default.
- W2770637178 cites W2088095316 @default.
- W2770637178 cites W2091161969 @default.
- W2770637178 cites W2108301702 @default.
- W2770637178 cites W2110326240 @default.
- W2770637178 cites W2117991443 @default.
- W2770637178 cites W2125435699 @default.
- W2770637178 cites W2126598648 @default.
- W2770637178 cites W2144137532 @default.
- W2770637178 cites W2146573461 @default.
- W2770637178 cites W2149067299 @default.
- W2770637178 cites W2153525556 @default.
- W2770637178 cites W2164346983 @default.
- W2770637178 cites W2208311430 @default.
- W2770637178 cites W2226947704 @default.
- W2770637178 cites W2235523093 @default.
- W2770637178 cites W2262061549 @default.
- W2770637178 cites W2268172084 @default.
- W2770637178 cites W2272984102 @default.
- W2770637178 cites W2293049688 @default.
- W2770637178 cites W2296806275 @default.
- W2770637178 cites W2296934997 @default.
- W2770637178 cites W2300667207 @default.
- W2770637178 cites W2302061252 @default.
- W2770637178 cites W2305883580 @default.
- W2770637178 cites W2397235816 @default.
- W2770637178 cites W2413443807 @default.
- W2770637178 cites W2415729167 @default.
- W2770637178 cites W2417073627 @default.
- W2770637178 cites W2428635620 @default.
- W2770637178 cites W2432902001 @default.
- W2770637178 cites W2437007202 @default.
- W2770637178 cites W2461500591 @default.
- W2770637178 cites W2463914344 @default.
- W2770637178 cites W2466324921 @default.
- W2770637178 cites W2467830390 @default.
- W2770637178 cites W2468594717 @default.
- W2770637178 cites W2468596032 @default.
- W2770637178 cites W2475286376 @default.
- W2770637178 cites W2488845020 @default.
- W2770637178 cites W2489216875 @default.
- W2770637178 cites W2506702259 @default.
- W2770637178 cites W2507951309 @default.
- W2770637178 cites W2514736378 @default.
- W2770637178 cites W2518772378 @default.
- W2770637178 cites W2521843363 @default.
- W2770637178 cites W2524219270 @default.
- W2770637178 cites W2547557128 @default.
- W2770637178 cites W2556708394 @default.
- W2770637178 cites W3022903699 @default.
- W2770637178 cites W303995039 @default.
- W2770637178 cites W320082861 @default.
- W2770637178 cites W4234157358 @default.