Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770653485> ?p ?o ?g. }
- W2770653485 endingPage "e13162" @default.
- W2770653485 startingPage "e13162" @default.
- W2770653485 abstract "Little is known about the impact of CYP3A5 polymorphisms on transplantation outcomes among African American (AA) kidney transplant recipients (KTRs). To assess this issue, clinical outcomes were compared between AA CYP3A5*1 expressers and nonexpressers. This retrospective cohort study analyzed AA KTRs. Biopsy-proven acute rejection (BPAR), delayed graft function (DGF), glomerular filtration rate (GFR), infections, and tacrolimus dosing requirements were examined in 106 immunologically high-risk AA kidney transplant patients over a 2-year follow-up period. In CYP3A5*1 expressers compared to nonexpressers, the incidence of BPAR was significantly higher in the first 6 months (13% vs 0%; P = .016) compared to 24 months (13% vs 7%; P = .521). Tacrolimus total daily dose at first therapeutic level was significantly higher in CYP3A5*1 expressers (12 mg/day) compared to nonexpressers (8 mg/day; P < .001). Compared to CYP3A5*1 nonexpressers, DGF incidence was significantly higher among CYP3A5*1 expressers (27.6% vs 6.7%; P = .006). By contrast, median GFR was significantly higher in CYP3A5*1 expressers compared to nonexpressers (54.5 mL/min vs 50.0 mL/min; P = .003) at 24 months. The findings from this retrospective study suggest that AAs with CYP3A5*1 expression require 50% more tacrolimus and have an increased incidence of DGF and acute rejection." @default.
- W2770653485 created "2017-12-04" @default.
- W2770653485 creator A5033267569 @default.
- W2770653485 creator A5041436470 @default.
- W2770653485 creator A5051224879 @default.
- W2770653485 creator A5073046216 @default.
- W2770653485 creator A5088184176 @default.
- W2770653485 date "2017-12-25" @default.
- W2770653485 modified "2023-09-26" @default.
- W2770653485 title "Impact of CYP3A5 genomic variances on clinical outcomes among African American kidney transplant recipients" @default.
- W2770653485 cites W119534424 @default.
- W2770653485 cites W1744376040 @default.
- W2770653485 cites W1936240115 @default.
- W2770653485 cites W1970851902 @default.
- W2770653485 cites W1983808856 @default.
- W2770653485 cites W1988422170 @default.
- W2770653485 cites W1990937119 @default.
- W2770653485 cites W1992188999 @default.
- W2770653485 cites W1999502217 @default.
- W2770653485 cites W2002737967 @default.
- W2770653485 cites W2017504805 @default.
- W2770653485 cites W2025916891 @default.
- W2770653485 cites W2025980792 @default.
- W2770653485 cites W2033139608 @default.
- W2770653485 cites W2034728660 @default.
- W2770653485 cites W2038803245 @default.
- W2770653485 cites W2038989721 @default.
- W2770653485 cites W2053907298 @default.
- W2770653485 cites W2055457865 @default.
- W2770653485 cites W2060508116 @default.
- W2770653485 cites W2099937170 @default.
- W2770653485 cites W2105902511 @default.
- W2770653485 cites W2108298583 @default.
- W2770653485 cites W2109956641 @default.
- W2770653485 cites W2117184184 @default.
- W2770653485 cites W2118874670 @default.
- W2770653485 cites W2124455178 @default.
- W2770653485 cites W2146837949 @default.
- W2770653485 cites W2153904763 @default.
- W2770653485 cites W2164539379 @default.
- W2770653485 cites W2210812892 @default.
- W2770653485 cites W2213256118 @default.
- W2770653485 cites W2298426707 @default.
- W2770653485 cites W2302802827 @default.
- W2770653485 cites W2314383809 @default.
- W2770653485 cites W2358501499 @default.
- W2770653485 cites W2410226431 @default.
- W2770653485 cites W2551933589 @default.
- W2770653485 cites W2583839262 @default.
- W2770653485 cites W2626704881 @default.
- W2770653485 cites W2770766047 @default.
- W2770653485 cites W2917257812 @default.
- W2770653485 doi "https://doi.org/10.1111/ctr.13162" @default.
- W2770653485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29161757" @default.
- W2770653485 hasPublicationYear "2017" @default.
- W2770653485 type Work @default.
- W2770653485 sameAs 2770653485 @default.
- W2770653485 citedByCount "15" @default.
- W2770653485 countsByYear W27706534852019 @default.
- W2770653485 countsByYear W27706534852020 @default.
- W2770653485 countsByYear W27706534852021 @default.
- W2770653485 countsByYear W27706534852022 @default.
- W2770653485 countsByYear W27706534852023 @default.
- W2770653485 crossrefType "journal-article" @default.
- W2770653485 hasAuthorship W2770653485A5033267569 @default.
- W2770653485 hasAuthorship W2770653485A5041436470 @default.
- W2770653485 hasAuthorship W2770653485A5051224879 @default.
- W2770653485 hasAuthorship W2770653485A5073046216 @default.
- W2770653485 hasAuthorship W2770653485A5088184176 @default.
- W2770653485 hasConcept C104317684 @default.
- W2770653485 hasConcept C120665830 @default.
- W2770653485 hasConcept C121332964 @default.
- W2770653485 hasConcept C126322002 @default.
- W2770653485 hasConcept C126894567 @default.
- W2770653485 hasConcept C135763542 @default.
- W2770653485 hasConcept C159641895 @default.
- W2770653485 hasConcept C167135981 @default.
- W2770653485 hasConcept C2777288759 @default.
- W2770653485 hasConcept C2780091579 @default.
- W2770653485 hasConcept C2780303639 @default.
- W2770653485 hasConcept C2909675724 @default.
- W2770653485 hasConcept C2911091166 @default.
- W2770653485 hasConcept C2994498544 @default.
- W2770653485 hasConcept C55493867 @default.
- W2770653485 hasConcept C61511704 @default.
- W2770653485 hasConcept C71924100 @default.
- W2770653485 hasConcept C86803240 @default.
- W2770653485 hasConcept C90924648 @default.
- W2770653485 hasConcept C92137452 @default.
- W2770653485 hasConceptScore W2770653485C104317684 @default.
- W2770653485 hasConceptScore W2770653485C120665830 @default.
- W2770653485 hasConceptScore W2770653485C121332964 @default.
- W2770653485 hasConceptScore W2770653485C126322002 @default.
- W2770653485 hasConceptScore W2770653485C126894567 @default.
- W2770653485 hasConceptScore W2770653485C135763542 @default.
- W2770653485 hasConceptScore W2770653485C159641895 @default.
- W2770653485 hasConceptScore W2770653485C167135981 @default.
- W2770653485 hasConceptScore W2770653485C2777288759 @default.