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• W2770656469 abstract "This study was aimed to compare clinical features, treatments outcomes and tolerability between young (18–45 years), middle age (46–64 years) and old (≥ 65 years) patients treated with bilateral ECT for treatment resistant major depressive episode. 402 patients were evaluated 1 day prior to ECT and a week after the treatment termination using the Clinical Global Impression Scale (CGI), the Hamilton Rating Scale for Depression-17 items (HAM-D-17), the Brief Psychiatric Rating Scale (BPRS), the Young Mania Rating Scale (YMRS) and the Mini Mental State Examination (MMSE). Response was defined as a reduction of at least 50% from baseline on the HAM-D-17 score. Remission was defined as a score ≤ 7 on the HAM-D-17 at the final evaluation. Rates of response were not statistically different in the three groups (69.6% in old versus 63.5% in young and 55.5% in middle age groups). No significant differences were also observed in the proportions of remitters between the age groups (31.4% in young group, 27.7% in middle age group and 29.3% in old group). One week after the end of the ECT course the middle and old age groups showed a statistically significant increase in the MMSE score compared to baseline. We did not find significant differences between the three age groups in rates of premature drops-out due to ECT-related side effects. Our data support the use of ECT in elderly patients with treatment-resistant major depressive episode, with rates of response around 70% and effectiveness being independent from age. In the old age group the baseline cognitive impairment improved after ECT and no life-threatening adverse event was detected." @default.
• W2770656469 created "2017-12-04" @default.
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• W2770656469 date "2018-02-01" @default.
• W2770656469 modified "2023-10-18" @default.
• W2770656469 title "Electroconvulsive therapy and age: Age-related clinical features and effectiveness in treatment resistant major depressive episode" @default.
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• W2770656469 doi "https://doi.org/10.1016/j.jad.2017.11.064" @default.
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• W2770656469 hasPublicationYear "2018" @default.
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