FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770660897> ?p ?o ?g. }

• W2770660897 abstract "Our previous proteomic study indicated that connective tissue growth factor (CTGF) may be a potential biomarker for rheumatoid arthritis (RA) diagnosis. The aim was to assess the performance of CTGF as a biomarker of RA.Serum and synovial fluid CTGF was detected using a direct high sensitivity sandwich ELISA kit. Serum CTGF levels were tested for discriminatory capacity and optimal assay cutoffs determined in a training cohort of 98 cases of RA with 103 healthy controls. The assay performance was then validated in a further cohort of 572 patients (with RA (n = 217), ankylosing spondylitis (n = 92), gout (n = 74), osteoarthritis (n = 52), systemic lupus erythematosus (n = 72), or primary Sjögren's syndrome (pSS) (n = 65)).Significant elevation of synovial fluid CTGF concentration was found in RA patients, demonstrating excellent diagnostic ability to predict RA (area under the curve (AUC) = 0.97). Similar results were found in serum CTGF detection. At the optimal cutoff value 88.66 pg/mL, the sensitivity, specificity, and the AUC was 0.86, 0.92, and 0.92, respectively, in the training cohort. Similar performance was observed in the validation cohort, with sensitivity, specificity, positive likelihood, and negative likelihood of 0.82, 0.91, 5.74, and 0.12, respectively. Stronger discriminatory capacity was seen with the combination of CTGF and anti-citrullinated protein antibody (ACPA) (AUC = 0.96) than with either ACPA or rheumatoid factor (RF) alone (AUC = 0.80 or 0.79, respectively). The discriminatory performance of serum CTGF was consistent across all inflammatory conditions tested (AUC >0.92 in all cases), with the sole exception of pSS. Serum CTGF did not vary with symptom duration or disease activity.Serum CTGF is a promising diagnostic biomarker for RA, with performance in the current study better than either ACPA or RF." @default.
• W2770660897 created "2017-12-04" @default.
• W2770660897 creator A5006817439 @default.
• W2770660897 creator A5013160428 @default.
• W2770660897 creator A5015368867 @default.
• W2770660897 creator A5016664084 @default.
• W2770660897 creator A5029041901 @default.
• W2770660897 creator A5032626397 @default.
• W2770660897 creator A5034579434 @default.
• W2770660897 creator A5062637916 @default.
• W2770660897 creator A5063691131 @default.
• W2770660897 creator A5063861565 @default.
• W2770660897 creator A5068911822 @default.
• W2770660897 creator A5090988809 @default.
• W2770660897 date "2017-11-22" @default.
• W2770660897 modified "2023-10-05" @default.
• W2770660897 title "Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis" @default.
• W2770660897 cites W1853412709 @default.
• W2770660897 cites W1965869178 @default.
• W2770660897 cites W1971912176 @default.
• W2770660897 cites W1973119160 @default.
• W2770660897 cites W1979122784 @default.
• W2770660897 cites W1990054263 @default.
• W2770660897 cites W1992596654 @default.
• W2770660897 cites W2011487877 @default.
• W2770660897 cites W2032221360 @default.
• W2770660897 cites W2046298589 @default.
• W2770660897 cites W2066507973 @default.
• W2770660897 cites W2070985580 @default.
• W2770660897 cites W2089597165 @default.
• W2770660897 cites W2092640063 @default.
• W2770660897 cites W2103119488 @default.
• W2770660897 cites W2123805036 @default.
• W2770660897 cites W2128952811 @default.
• W2770660897 cites W2145649086 @default.
• W2770660897 cites W2147182063 @default.
• W2770660897 cites W2149768460 @default.
• W2770660897 cites W2153844601 @default.
• W2770660897 cites W2156758677 @default.
• W2770660897 cites W2169804478 @default.
• W2770660897 cites W2339174221 @default.
• W2770660897 cites W2344839616 @default.
• W2770660897 cites W4241917186 @default.
• W2770660897 cites W74939269 @default.
• W2770660897 cites W56279009 @default.
• W2770660897 doi "https://doi.org/10.1186/s13075-017-1463-1" @default.
• W2770660897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5700625" @default.
• W2770660897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29166915" @default.
• W2770660897 hasPublicationYear "2017" @default.
• W2770660897 type Work @default.
• W2770660897 sameAs 2770660897 @default.
• W2770660897 citedByCount "21" @default.
• W2770660897 countsByYear W27706608972018 @default.
• W2770660897 countsByYear W27706608972019 @default.
• W2770660897 countsByYear W27706608972020 @default.
• W2770660897 countsByYear W27706608972021 @default.
• W2770660897 countsByYear W27706608972022 @default.
• W2770660897 countsByYear W27706608972023 @default.
• W2770660897 crossrefType "journal-article" @default.
• W2770660897 hasAuthorship W2770660897A5006817439 @default.
• W2770660897 hasAuthorship W2770660897A5013160428 @default.
• W2770660897 hasAuthorship W2770660897A5015368867 @default.
• W2770660897 hasAuthorship W2770660897A5016664084 @default.
• W2770660897 hasAuthorship W2770660897A5029041901 @default.
• W2770660897 hasAuthorship W2770660897A5032626397 @default.
• W2770660897 hasAuthorship W2770660897A5034579434 @default.
• W2770660897 hasAuthorship W2770660897A5062637916 @default.
• W2770660897 hasAuthorship W2770660897A5063691131 @default.
• W2770660897 hasAuthorship W2770660897A5063861565 @default.
• W2770660897 hasAuthorship W2770660897A5068911822 @default.
• W2770660897 hasAuthorship W2770660897A5090988809 @default.
• W2770660897 hasBestOaLocation W27706608971 @default.
• W2770660897 hasConcept C126322002 @default.
• W2770660897 hasConcept C142724271 @default.
• W2770660897 hasConcept C170493617 @default.
• W2770660897 hasConcept C185592680 @default.
• W2770660897 hasConcept C198451711 @default.
• W2770660897 hasConcept C203014093 @default.
• W2770660897 hasConcept C204787440 @default.
• W2770660897 hasConcept C2775960820 @default.
• W2770660897 hasConcept C2776164576 @default.
• W2770660897 hasConcept C2776232647 @default.
• W2770660897 hasConcept C2776268809 @default.
• W2770660897 hasConcept C2777575956 @default.
• W2770660897 hasConcept C2780631158 @default.
• W2770660897 hasConcept C2781197716 @default.
• W2770660897 hasConcept C518705261 @default.
• W2770660897 hasConcept C55493867 @default.
• W2770660897 hasConcept C71924100 @default.
• W2770660897 hasConcept C72563966 @default.
• W2770660897 hasConcept C90924648 @default.
• W2770660897 hasConceptScore W2770660897C126322002 @default.
• W2770660897 hasConceptScore W2770660897C142724271 @default.
• W2770660897 hasConceptScore W2770660897C170493617 @default.
• W2770660897 hasConceptScore W2770660897C185592680 @default.
• W2770660897 hasConceptScore W2770660897C198451711 @default.
• W2770660897 hasConceptScore W2770660897C203014093 @default.
• W2770660897 hasConceptScore W2770660897C204787440 @default.
• W2770660897 hasConceptScore W2770660897C2775960820 @default.
• W2770660897 hasConceptScore W2770660897C2776164576 @default.

• next