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• W2770660972 abstract "Abstract Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of extracellular matrix (ECM) proteins. In this study, we aimed to investigate the correlation of the urinary proteome classifier CKD273 and individual urinary peptides with the degree of fibrosis. In total, 42 kidney biopsies and urine samples were examined. The percentage of fibrosis per total tissue area was assessed in Masson trichrome stained kidney tissues. The urinary proteome was analysed by capillary electrophoresis coupled to mass spectrometry. CKD273 displayed a significant and positive correlation with the degree of fibrosis (Rho = 0.430, P = 0.0044), while the routinely used parameters (glomerular filtration rate, urine albumin-to-creatinine ratio and urine protein-to-creatinine ratio) did not (Rho = −0.222; −0.137; −0.070 and P = 0.16; 0.39; 0.66, respectively). We identified seven fibrosis-associated peptides displaying a significant and negative correlation with the degree of fibrosis. All peptides were collagen fragments, suggesting that these may be causally related to the observed accumulation of ECM in the kidneys. CKD273 and specific peptides are significantly associated with kidney fibrosis; such an association could not be detected by other biomarkers for CKD. These non-invasive fibrosis-related biomarkers can potentially be implemented in future trials." @default.
• W2770660972 created "2017-12-04" @default.
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• W2770660972 date "2017-12-05" @default.
• W2770660972 modified "2023-10-17" @default.
• W2770660972 title "Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?" @default.
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• W2770660972 cites W1973002697 @default.
• W2770660972 cites W1999019754 @default.
• W2770660972 cites W2000654719 @default.
• W2770660972 cites W2004799239 @default.
• W2770660972 cites W2017585199 @default.
• W2770660972 cites W2018079417 @default.
• W2770660972 cites W2020992600 @default.
• W2770660972 cites W2022964019 @default.
• W2770660972 cites W2023849301 @default.
• W2770660972 cites W2028509886 @default.
• W2770660972 cites W2031224882 @default.
• W2770660972 cites W2033457930 @default.
• W2770660972 cites W2036601168 @default.
• W2770660972 cites W2043575472 @default.
• W2770660972 cites W2044747742 @default.
• W2770660972 cites W2045142779 @default.
• W2770660972 cites W2045516356 @default.
• W2770660972 cites W2047655143 @default.
• W2770660972 cites W2050915853 @default.
• W2770660972 cites W2059174167 @default.
• W2770660972 cites W2067995476 @default.
• W2770660972 cites W2068086594 @default.
• W2770660972 cites W2081052078 @default.
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• W2770660972 cites W2164249826 @default.
• W2770660972 cites W2164370129 @default.
• W2770660972 cites W2164650754 @default.
• W2770660972 cites W2277416529 @default.
• W2770660972 cites W2289876298 @default.
• W2770660972 cites W2466735922 @default.
• W2770660972 cites W2467227824 @default.
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• W2770660972 doi "https://doi.org/10.1038/s41598-017-17083-w" @default.
• W2770660972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5717105" @default.
• W2770660972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29208969" @default.
• W2770660972 hasPublicationYear "2017" @default.
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