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- W2770664623 abstract "Abstract The field of m6A modification and epitranscriptomics has recently attracted much attention. More methods allowing for precise m6A site profiling and location are developed and crucial players of m6A modification machinery are increasingly identified. Although some challenges remain, m6A modification is found to modulate almost all aspects of RNA metabolism, such as splicing, stability, structure, translation, and export. Thus, m6A modification adds a new layer of post-transcriptional gene expression regulation, and it is implicated in T cell response to HIV infection, type I interferon production, and T cell differentiation and homeostasis. Moreover, evidence supporting its involvement in various human diseases including cancers is accumulating. Given the role of m6A modification in gene expression regulation and immune response, it invites the speculation that m6A modification may justify the pathogenesis of systemic lupus erythematosus (SLE) and take part in the initiation and progression of SLE. In this review, we introduce the widespread existence of m6A modification and briefly discuss components of m6A modification machinery in mammals. We mainly summarize the studies reporting the mechanisms of m6A modification in gene expression regulation through modulating pre-mRNA splicing, mRNA stability, RNA structure, translation, and pri-miRNA processing. Biological functions related to immune response of m6A modification and the implication of m6A modification in cancers are highlighted. In the end, we surmise the potential link between m6A modification and SLE." @default.
- W2770664623 created "2017-12-04" @default.
- W2770664623 creator A5012392737 @default.
- W2770664623 creator A5027899169 @default.
- W2770664623 creator A5051283655 @default.
- W2770664623 creator A5057503770 @default.
- W2770664623 creator A5072108606 @default.
- W2770664623 date "2018-01-01" @default.
- W2770664623 modified "2023-10-17" @default.
- W2770664623 title "Potential link between m 6 A modification and systemic lupus erythematosus" @default.
- W2770664623 cites W1162664746 @default.
- W2770664623 cites W144423133 @default.
- W2770664623 cites W1539394838 @default.
- W2770664623 cites W1626755795 @default.
- W2770664623 cites W1885991053 @default.
- W2770664623 cites W1886240449 @default.
- W2770664623 cites W1895681508 @default.
- W2770664623 cites W1933156045 @default.
- W2770664623 cites W1941339056 @default.
- W2770664623 cites W1965158257 @default.
- W2770664623 cites W1972238386 @default.
- W2770664623 cites W1981629946 @default.
- W2770664623 cites W1981857432 @default.
- W2770664623 cites W1982749428 @default.
- W2770664623 cites W1985875309 @default.
- W2770664623 cites W1986836580 @default.
- W2770664623 cites W1991807334 @default.
- W2770664623 cites W2002458471 @default.
- W2770664623 cites W2006629258 @default.
- W2770664623 cites W2007429249 @default.
- W2770664623 cites W2008462446 @default.
- W2770664623 cites W2009308529 @default.
- W2770664623 cites W2011131953 @default.
- W2770664623 cites W2015217788 @default.
- W2770664623 cites W2022129953 @default.
- W2770664623 cites W2022770379 @default.
- W2770664623 cites W2028978761 @default.
- W2770664623 cites W2029979788 @default.
- W2770664623 cites W2037754272 @default.
- W2770664623 cites W2038130635 @default.
- W2770664623 cites W2038392117 @default.
- W2770664623 cites W2041328373 @default.
- W2770664623 cites W2042003093 @default.
- W2770664623 cites W2058835062 @default.
- W2770664623 cites W2059357290 @default.
- W2770664623 cites W2060902122 @default.
- W2770664623 cites W2063530272 @default.
- W2770664623 cites W2064165694 @default.
- W2770664623 cites W2065847836 @default.
- W2770664623 cites W2071930821 @default.
- W2770664623 cites W2072127157 @default.
- W2770664623 cites W2078357230 @default.
- W2770664623 cites W2078964320 @default.
- W2770664623 cites W2079267760 @default.
- W2770664623 cites W2081416658 @default.
- W2770664623 cites W2085106808 @default.
- W2770664623 cites W2088860412 @default.
- W2770664623 cites W2091235283 @default.
- W2770664623 cites W2093764457 @default.
- W2770664623 cites W2095925082 @default.
- W2770664623 cites W2096388504 @default.
- W2770664623 cites W2102872651 @default.
- W2770664623 cites W2104706770 @default.
- W2770664623 cites W2107294782 @default.
- W2770664623 cites W2117691694 @default.
- W2770664623 cites W2121208026 @default.
- W2770664623 cites W2126165721 @default.
- W2770664623 cites W2130077869 @default.
- W2770664623 cites W2133616902 @default.
- W2770664623 cites W2136991248 @default.
- W2770664623 cites W2152891840 @default.
- W2770664623 cites W2156714600 @default.
- W2770664623 cites W2161890613 @default.
- W2770664623 cites W2163749231 @default.
- W2770664623 cites W2164693982 @default.
- W2770664623 cites W2165547003 @default.
- W2770664623 cites W2169494000 @default.
- W2770664623 cites W2175514210 @default.
- W2770664623 cites W2180404227 @default.
- W2770664623 cites W2191528442 @default.
- W2770664623 cites W2255613730 @default.
- W2770664623 cites W2269054226 @default.
- W2770664623 cites W2271995006 @default.
- W2770664623 cites W2306179365 @default.
- W2770664623 cites W2327216023 @default.
- W2770664623 cites W2342299314 @default.
- W2770664623 cites W2403990263 @default.
- W2770664623 cites W2414784657 @default.
- W2770664623 cites W2461624292 @default.
- W2770664623 cites W2490260731 @default.
- W2770664623 cites W2507685096 @default.
- W2770664623 cites W2536779669 @default.
- W2770664623 cites W2551404503 @default.
- W2770664623 cites W2575691519 @default.
- W2770664623 cites W2578506026 @default.
- W2770664623 cites W2579378735 @default.
- W2770664623 cites W2589225545 @default.
- W2770664623 cites W2592988313 @default.