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• W2770696598 abstract "The circuitry mediating top-down control of dopamine (DA) neurons in the ventral tegmental area (VTA) is exceedingly complex. Characterizing these networks will be critical to our understanding of fundamental behaviors, such as motivation and reward processing, as well as several disease states. Previous work suggests that the medial prefrontal cortex (mPFC) exerts a profound influence on VTA DA neuron firing. Recently, our group reported that inhibition of the infralimbic subdivision of the medial prefrontal cortex (ilPFC) increases the proportion of VTA DA neurons that are spontaneously active (i.e., “population activity”) and that this effect depends on activity in the ventral subiculum of the hippocampus (vSub). However, there is no direct projection from the mPFC to the vSub. Anatomical evidence suggests that communication between the two structures is mediated by the nucleus reuniens of the midline thalamus (RE). The work presented in this dissertation aims to determine if RE controls VTA DA neuron firing and to describe the circuits underlying ilPFC-RE communication. In Chapter 2, we present findings demonstrating that RE can drive VTA DA neuron firing by engaging vSub. In addition, we show that ilPFC opposes this effect, likely via input to RE in the form of feedforward inhibition from TRN. In Chapter 3, we present findings that characterize the diverse array of RE neuron firing patterns in an intact preparation and describe the circuit dynamics underlying projections from ilPFC to RE. These studies suggest that ilPFC exerts control of RE neuron firing pattern through direct, monosynaptic connections and via the thalamic reticular nucleus (TRN). Overall, the studies described in this dissertation reveal a novel role for a corticothalamic circuit including the ilPFC, RE, and vSub in controlling VTA DA neuron firing and confirm that corticothalamic input from ilPFC to RE can modulate RE neuron firing pattern in nuanced and complex ways. In addition, these findings provide a plausible circuit basis for various behavioral phenomena observed in schizophrenia, and could help inform the development of novel treatments." @default.
• W2770696598 created "2017-12-04" @default.
• W2770696598 creator A5067955286 @default.
• W2770696598 date "2017-09-28" @default.
• W2770696598 modified "2023-09-23" @default.
• W2770696598 title "CIRCUIT DYNAMICS UNDERLYING CONTROL OF DOPAMINE NEURON ACTIVITY BY THE NUCLEUS REUNIENS OF THE MIDLINE THALAMUS" @default.
• W2770696598 cites W1502703412 @default.
• W2770696598 cites W1503309142 @default.
• W2770696598 cites W1514161587 @default.
• W2770696598 cites W1518890501 @default.
• W2770696598 cites W1537984399 @default.
• W2770696598 cites W1541446099 @default.
• W2770696598 cites W1550372013 @default.
• W2770696598 cites W1557514446 @default.
• W2770696598 cites W1565970281 @default.
• W2770696598 cites W1569664741 @default.
• W2770696598 cites W1579518684 @default.
• W2770696598 cites W1633847368 @default.
• W2770696598 cites W1772604871 @default.
• W2770696598 cites W1829380695 @default.
• W2770696598 cites W1840984304 @default.
• W2770696598 cites W1841190780 @default.
• W2770696598 cites W1844614575 @default.
• W2770696598 cites W1845479375 @default.
• W2770696598 cites W1865166881 @default.
• W2770696598 cites W1875506666 @default.
• W2770696598 cites W1921511099 @default.
• W2770696598 cites W1949404224 @default.
• W2770696598 cites W1964381117 @default.
• W2770696598 cites W1965453247 @default.
• W2770696598 cites W1965737679 @default.
• W2770696598 cites W1966207574 @default.
• W2770696598 cites W1966894251 @default.
• W2770696598 cites W1967531155 @default.
• W2770696598 cites W1968198840 @default.
• W2770696598 cites W1968714114 @default.
• W2770696598 cites W1969273085 @default.
• W2770696598 cites W1971690948 @default.
• W2770696598 cites W1973669148 @default.
• W2770696598 cites W1974176542 @default.
• W2770696598 cites W1975453639 @default.
• W2770696598 cites W1979581462 @default.
• W2770696598 cites W1980528265 @default.
• W2770696598 cites W1980938183 @default.
• W2770696598 cites W1981065427 @default.
• W2770696598 cites W1981514558 @default.
• W2770696598 cites W1981683953 @default.
• W2770696598 cites W1982278227 @default.
• W2770696598 cites W1984038015 @default.
• W2770696598 cites W1984141645 @default.
• W2770696598 cites W1984525171 @default.
• W2770696598 cites W1985029200 @default.
• W2770696598 cites W1985282639 @default.
• W2770696598 cites W1985885722 @default.
• W2770696598 cites W1987521590 @default.
• W2770696598 cites W1987824647 @default.
• W2770696598 cites W1989666477 @default.
• W2770696598 cites W1989820875 @default.
• W2770696598 cites W1990994399 @default.
• W2770696598 cites W1991934169 @default.
• W2770696598 cites W1992225639 @default.
• W2770696598 cites W1992563753 @default.
• W2770696598 cites W1992894736 @default.
• W2770696598 cites W1993547531 @default.
• W2770696598 cites W1994142018 @default.
• W2770696598 cites W1994984635 @default.
• W2770696598 cites W1996688534 @default.
• W2770696598 cites W1997523284 @default.
• W2770696598 cites W2011345925 @default.
• W2770696598 cites W2013074165 @default.
• W2770696598 cites W2014875293 @default.
• W2770696598 cites W2015057988 @default.
• W2770696598 cites W2015642749 @default.
• W2770696598 cites W2017296613 @default.
• W2770696598 cites W2017674801 @default.
• W2770696598 cites W2018703700 @default.
• W2770696598 cites W2020418921 @default.
• W2770696598 cites W2020528457 @default.
• W2770696598 cites W2020549903 @default.
• W2770696598 cites W2020867780 @default.
• W2770696598 cites W2023616594 @default.
• W2770696598 cites W2024406994 @default.
• W2770696598 cites W2027691566 @default.
• W2770696598 cites W2029942338 @default.
• W2770696598 cites W2030644595 @default.
• W2770696598 cites W2031336666 @default.
• W2770696598 cites W2031625841 @default.
• W2770696598 cites W2031811627 @default.
• W2770696598 cites W2035872682 @default.
• W2770696598 cites W2036009366 @default.
• W2770696598 cites W2037140171 @default.
• W2770696598 cites W2037650611 @default.
• W2770696598 cites W2039912069 @default.
• W2770696598 cites W2041457323 @default.
• W2770696598 cites W2044176879 @default.
• W2770696598 cites W2046081005 @default.
• W2770696598 cites W2047700846 @default.
• W2770696598 cites W2048024033 @default.
• W2770696598 cites W2048405858 @default.
• W2770696598 cites W2048661364 @default.

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