FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770696791> ?p ?o ?g. }

• W2770696791 endingPage "18535" @default.
• W2770696791 startingPage "18522" @default.
• W2770696791 abstract "Family A G protein-coupled receptors (GPCRs) control diverse biological processes and are of great clinical relevance. Their archetype rhodopsin becomes naturally light sensitive by binding covalently to the photoswitchable tethered ligand (PTL) retinal. Other GPCRs, however, neither bind covalently to ligands nor are light sensitive. We sought to impart the logic of rhodopsin to light-insensitive Family A GPCRs in order to enable their remote control in a receptor-specific, cell-type-specific, and spatiotemporally precise manner. Dopamine receptors (DARs) are of particular interest for their roles in motor coordination, appetitive, and aversive behavior, as well as neuropsychiatric disorders such as Parkinson's disease, schizophrenia, mood disorders, and addiction. Using an azobenzene derivative of the well-known DAR ligand 2-(N-phenethyl-N-propyl)amino-5-hydroxytetralin (PPHT), we were able to rapidly, reversibly, and selectively block dopamine D1 and D2 receptors (D1R and D2R) when the PTL was conjugated to an engineered cysteine near the dopamine binding site. Depending on the site of tethering, the ligand behaved as either a photoswitchable tethered neutral antagonist or inverse agonist. Our results indicate that DARs can be chemically engineered for selective remote control by light and provide a template for precision control of Family A GPCRs." @default.
• W2770696791 created "2017-12-04" @default.
• W2770696791 creator A5003690240 @default.
• W2770696791 creator A5023901317 @default.
• W2770696791 creator A5031211334 @default.
• W2770696791 creator A5042433434 @default.
• W2770696791 creator A5055314250 @default.
• W2770696791 creator A5076865147 @default.
• W2770696791 creator A5077132675 @default.
• W2770696791 creator A5081378606 @default.
• W2770696791 date "2017-12-13" @default.
• W2770696791 modified "2023-10-17" @default.
• W2770696791 title "Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist" @default.
• W2770696791 cites W1481198769 @default.
• W2770696791 cites W1488100833 @default.
• W2770696791 cites W1547923480 @default.
• W2770696791 cites W1586836520 @default.
• W2770696791 cites W18127766 @default.
• W2770696791 cites W1821702779 @default.
• W2770696791 cites W1833104430 @default.
• W2770696791 cites W1905955603 @default.
• W2770696791 cites W1913949000 @default.
• W2770696791 cites W1943789780 @default.
• W2770696791 cites W1965926793 @default.
• W2770696791 cites W1966627438 @default.
• W2770696791 cites W1968446819 @default.
• W2770696791 cites W1969077273 @default.
• W2770696791 cites W1977514547 @default.
• W2770696791 cites W1978310995 @default.
• W2770696791 cites W1980617113 @default.
• W2770696791 cites W1981875547 @default.
• W2770696791 cites W1984132657 @default.
• W2770696791 cites W1985588649 @default.
• W2770696791 cites W1987436909 @default.
• W2770696791 cites W1988097700 @default.
• W2770696791 cites W1988557853 @default.
• W2770696791 cites W1988821183 @default.
• W2770696791 cites W1992308470 @default.
• W2770696791 cites W1993130087 @default.
• W2770696791 cites W1998835042 @default.
• W2770696791 cites W2008649912 @default.
• W2770696791 cites W2009447429 @default.
• W2770696791 cites W2012798378 @default.
• W2770696791 cites W2020174502 @default.
• W2770696791 cites W2021031987 @default.
• W2770696791 cites W2025528306 @default.
• W2770696791 cites W2026279242 @default.
• W2770696791 cites W2026933998 @default.
• W2770696791 cites W2028645925 @default.
• W2770696791 cites W2029335938 @default.
• W2770696791 cites W2033398100 @default.
• W2770696791 cites W2036048932 @default.
• W2770696791 cites W2036381989 @default.
• W2770696791 cites W2037261940 @default.
• W2770696791 cites W2041526142 @default.
• W2770696791 cites W2043292527 @default.
• W2770696791 cites W2048830358 @default.
• W2770696791 cites W2061540554 @default.
• W2770696791 cites W2062941431 @default.
• W2770696791 cites W2078719550 @default.
• W2770696791 cites W2085102249 @default.
• W2770696791 cites W2085392760 @default.
• W2770696791 cites W2088335517 @default.
• W2770696791 cites W2089086104 @default.
• W2770696791 cites W2090891087 @default.
• W2770696791 cites W2092416470 @default.
• W2770696791 cites W2092754405 @default.
• W2770696791 cites W2096193724 @default.
• W2770696791 cites W2096525273 @default.
• W2770696791 cites W2097744565 @default.
• W2770696791 cites W2097815293 @default.
• W2770696791 cites W2104477830 @default.
• W2770696791 cites W2104961861 @default.
• W2770696791 cites W2109014958 @default.
• W2770696791 cites W2109963281 @default.
• W2770696791 cites W2110925924 @default.
• W2770696791 cites W2111444678 @default.
• W2770696791 cites W2118347518 @default.
• W2770696791 cites W2118536789 @default.
• W2770696791 cites W2119084501 @default.
• W2770696791 cites W2119692371 @default.
• W2770696791 cites W2127884559 @default.
• W2770696791 cites W2128060370 @default.
• W2770696791 cites W2130632774 @default.
• W2770696791 cites W2143656230 @default.
• W2770696791 cites W2144473795 @default.
• W2770696791 cites W2145602532 @default.
• W2770696791 cites W2147376890 @default.
• W2770696791 cites W2151088690 @default.
• W2770696791 cites W2151209974 @default.
• W2770696791 cites W2154500741 @default.
• W2770696791 cites W2155208284 @default.
• W2770696791 cites W2155599139 @default.
• W2770696791 cites W2156257459 @default.
• W2770696791 cites W2157844171 @default.
• W2770696791 cites W2162109316 @default.
• W2770696791 cites W2178407419 @default.
• W2770696791 cites W2199086289 @default.

• next