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- W2770745992 abstract "The identification of genetic factors associated with kidney disease has the potential to provide critical insights into disease mechanisms. Genome-wide association studies have uncovered genomic regions associated with renal function metrics and risk of CKD. UMOD is among the most outstanding loci associated with CKD in the general population, because it has a large effect on eGFR and CKD risk that is consistent across different ethnic groups. The relevance of UMOD for CKD is clear, because the encoded protein, uromodulin (Tamm–Horsfall protein), is exclusively produced by the kidney tubule and has specific biochemical properties that mediate important functions in the kidney and urine. Rare mutations in UMOD are the major cause of autosomal dominant tubulointerstitial kidney disease, a condition that leads to CKD and ESRD. In this brief review, we use the UMOD paradigm to describe how population genetic studies can yield insight into the pathogenesis and prognosis of kidney diseases." @default.
- W2770745992 created "2017-12-04" @default.
- W2770745992 creator A5010058481 @default.
- W2770745992 creator A5033792420 @default.
- W2770745992 date "2017-11-27" @default.
- W2770745992 modified "2023-10-15" @default.
- W2770745992 title "The <i>UMOD</i> Locus: Insights into the Pathogenesis and Prognosis of Kidney Disease" @default.
- W2770745992 cites W108682491 @default.
- W2770745992 cites W1567241254 @default.
- W2770745992 cites W1964042466 @default.
- W2770745992 cites W1966627741 @default.
- W2770745992 cites W1967490910 @default.
- W2770745992 cites W1971322148 @default.
- W2770745992 cites W1973002697 @default.
- W2770745992 cites W1977467688 @default.
- W2770745992 cites W1988532585 @default.
- W2770745992 cites W1989983735 @default.
- W2770745992 cites W1994501150 @default.
- W2770745992 cites W1997849573 @default.
- W2770745992 cites W2000541664 @default.
- W2770745992 cites W2014594852 @default.
- W2770745992 cites W2018462584 @default.
- W2770745992 cites W2034932295 @default.
- W2770745992 cites W2046122623 @default.
- W2770745992 cites W2051718666 @default.
- W2770745992 cites W2052362972 @default.
- W2770745992 cites W2067021754 @default.
- W2770745992 cites W2069492401 @default.
- W2770745992 cites W2074921359 @default.
- W2770745992 cites W2087799322 @default.
- W2770745992 cites W2089964275 @default.
- W2770745992 cites W2093964879 @default.
- W2770745992 cites W2094076742 @default.
- W2770745992 cites W2095746901 @default.
- W2770745992 cites W2096545844 @default.
- W2770745992 cites W2099739381 @default.
- W2770745992 cites W2101794801 @default.
- W2770745992 cites W2104549677 @default.
- W2770745992 cites W2105885585 @default.
- W2770745992 cites W2106137223 @default.
- W2770745992 cites W2108525019 @default.
- W2770745992 cites W2110808585 @default.
- W2770745992 cites W2111285312 @default.
- W2770745992 cites W2115378896 @default.
- W2770745992 cites W2117362890 @default.
- W2770745992 cites W2120798274 @default.
- W2770745992 cites W2121662608 @default.
- W2770745992 cites W2121793978 @default.
- W2770745992 cites W2121923232 @default.
- W2770745992 cites W2122084492 @default.
- W2770745992 cites W2124632681 @default.
- W2770745992 cites W2124641083 @default.
- W2770745992 cites W2127091950 @default.
- W2770745992 cites W2128384816 @default.
- W2770745992 cites W2129290944 @default.
- W2770745992 cites W2130246960 @default.
- W2770745992 cites W2141198361 @default.
- W2770745992 cites W2141913464 @default.
- W2770745992 cites W2149368867 @default.
- W2770745992 cites W2150943752 @default.
- W2770745992 cites W2153025581 @default.
- W2770745992 cites W2160180886 @default.
- W2770745992 cites W2161171014 @default.
- W2770745992 cites W2165019590 @default.
- W2770745992 cites W2165238174 @default.
- W2770745992 cites W2169010952 @default.
- W2770745992 cites W2169314667 @default.
- W2770745992 cites W2171315731 @default.
- W2770745992 cites W2183868793 @default.
- W2770745992 cites W2196647469 @default.
- W2770745992 cites W2225021934 @default.
- W2770745992 cites W2225514345 @default.
- W2770745992 cites W2254854962 @default.
- W2770745992 cites W2274048411 @default.
- W2770745992 cites W2304123274 @default.
- W2770745992 cites W2333983113 @default.
- W2770745992 cites W2395814425 @default.
- W2770745992 cites W2403475034 @default.
- W2770745992 cites W2411709723 @default.
- W2770745992 cites W2488281607 @default.
- W2770745992 cites W2500671045 @default.
- W2770745992 cites W2511515754 @default.
- W2770745992 cites W2514105479 @default.
- W2770745992 cites W2522178069 @default.
- W2770745992 cites W2529940632 @default.
- W2770745992 cites W2541811369 @default.
- W2770745992 cites W2546142619 @default.
- W2770745992 cites W2559817772 @default.
- W2770745992 cites W2580404806 @default.
- W2770745992 cites W2586927659 @default.
- W2770745992 cites W2588717414 @default.
- W2770745992 cites W2588793161 @default.
- W2770745992 cites W2588878740 @default.
- W2770745992 cites W2593934696 @default.
- W2770745992 cites W2597132418 @default.
- W2770745992 cites W2597294414 @default.
- W2770745992 cites W2605367048 @default.
- W2770745992 cites W2607179358 @default.