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- W2770793757 endingPage "286" @default.
- W2770793757 startingPage "271" @default.
- W2770793757 abstract "Skin and soft tissue infections classified as acute bacterial skin and skin structure infections (ABSSSIs) constitute an injury caused by microorganisms that affect skin and surrounding soft tissues. The etiological agents that produce this disease are common Gram-positive bacteria, such as Staphylococcus aureus including methicillin-resistant S. aureus (MRSA), S. epidermidis, Corynebacterium species and Streptococcus pyogenes. Currently, due to the high exposure to antibiotics and prolonged hospital stays, there is a significant increase in infections caused by Pseudomonas aeruginosa, Enterococcus species, as well as Escherichia coli and other Enterobacteriaceae species. In hospitals 7%–10% of the patients admitted can develop an ABSSSI. There is a need for novel drug delivery systems that can improve the therapeutic index of the currently available antimicrobial drugs, as well as for new controlled-release mechanisms that can enhance tissue penetration without irritation. Likewise, screening platforms for these new products that determine penetration, antimicrobial activity and dermal toxicity have not been introduced in a rational model of evaluation and validation. The aim of this chapter is to give an integrated approach to the use of drug delivery systems with penetration enhancers from natural products and new formulations, as well as a rational strategy of evaluation and validation of the obtained products for the treatment of ABSSSIs." @default.
- W2770793757 created "2017-12-04" @default.
- W2770793757 creator A5037906841 @default.
- W2770793757 creator A5052105470 @default.
- W2770793757 creator A5052130718 @default.
- W2770793757 date "2017-01-01" @default.
- W2770793757 modified "2023-09-26" @default.
- W2770793757 title "Antimicrobial Strategies in Novel Drug Delivery Systems" @default.
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