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- W2770816257 abstract "The pathogenesis of non-small cell lung cancer (NSCLC) is regulated by various miRNAs. In this study, we identified that miR-875-5pis up-regulated in NSCLC patients, and inhibited SATB Homeobox 2(SATB2) to promote proliferation and invasion of NSCLCcells.CCK-8assay revealed thatmiR-875-5p mimics promoted proliferation of NSCLC cells. Transwell assay showed that miR-875-5pmimicspromoted the invasion and migration of NSCLC cells. Luciferase assays confirmed that miR-875-5pdirectly binds to the 3'untranslated region of SATB2, and western blotting showed that miR-875-5psuppresses the expression of SATB2 at the protein level. Moreover, the inhibitors of miR-875-5pinhibit proliferation and invasion of NSCLC cell lines. The miR-875-5pwouldbe a potential therapeutic target for NSCLC treatment in the future." @default.
- W2770816257 created "2017-12-04" @default.
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- W2770816257 date "2018-02-01" @default.
- W2770816257 modified "2023-09-23" @default.
- W2770816257 title "The miR-875-5p inhibits SATB2 to promote the invasion of lung cancer cells" @default.
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- W2770816257 doi "https://doi.org/10.1016/j.gene.2017.11.066" @default.
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