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- W2770856807 abstract "Abstract Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti‐Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit (MRPL) for urinary T is 30 ng/mL. However, the data about the urinary excretion of T after oral administration is limited. We investigate the elimination profile and determine whether single‐dose administration of T would cause a positive doping result. Twelve healthy volunteers received a single‐dose of 4‐mg T rally, and urine samples were collected for 24 hours. A validated liquid chromatography–tandem mass spectrometry method was used to determine urinary T levels. Non‐compartmental modeling was used to estimate the pharmacokinetic parameters. All the urinary T concentrations were much higher than the MRPL. The peak urinary T concentration was 3211.4 ± 860.3 ng/mL (mean ± SD), time to peak concentration was 1.7 ± 0.9 hours, and the estimated elimination half‐life was 4.4 ± 2.8 hours. About 27.76% of the consumed dose was eliminated via urine within 24 hours of intake. After a single‐dose oral administration, urinary T concentrations still exceeded the MRPL after 24 hours. This information could be useful for limiting the misuse of T. Athletes should be aware when using T in competition and acquire approval for a therapeutic use exemption prior to use. Moreover, the elimination profile of orally administered T may be crucial information for distinguishing different dosage routes." @default.
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- W2770856807 date "2017-12-11" @default.
- W2770856807 modified "2023-09-27" @default.
- W2770856807 title "Elimination profile of triamcinolone in urine following oral administration" @default.
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- W2770856807 doi "https://doi.org/10.1002/dta.2343" @default.
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