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- W2770859189 abstract "Pluripotency is defined by a cell's potential to differentiate into any somatic cell type. How pluripotency is transited during embryo implantation, followed by cell lineage specification and establishment of the basic body plan, is poorly understood. Here we report the transcription factor Zfp281 functions in the exit from naive pluripotency occurring coincident with pre-to-post-implantation mouse embryonic development. By characterizing Zfp281 mutant phenotypes and identifying Zfp281 gene targets and protein partners in developing embryos and cultured pluripotent stem cells, we establish critical roles for Zfp281 in activating components of the Nodal signaling pathway and lineage-specific genes. Mechanistically, Zfp281 cooperates with histone acetylation and methylation complexes at target gene enhancers and promoters to exert transcriptional activation and repression, as well as epigenetic control of epiblast maturation leading up to anterior-posterior axis specification. Our study provides a comprehensive molecular model for understanding pluripotent state progressions in vivo during mammalian embryonic development." @default.
- W2770859189 created "2017-12-04" @default.
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- W2770859189 date "2017-11-23" @default.
- W2770859189 modified "2023-10-06" @default.
- W2770859189 title "Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling" @default.
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- W2770859189 cites W1811961634 @default.
- W2770859189 cites W1922106993 @default.
- W2770859189 cites W1967065086 @default.
- W2770859189 cites W1968931043 @default.
- W2770859189 cites W1969385440 @default.
- W2770859189 cites W1975200987 @default.
- W2770859189 cites W1982805576 @default.
- W2770859189 cites W1989874642 @default.
- W2770859189 cites W1992788426 @default.
- W2770859189 cites W2003028861 @default.
- W2770859189 cites W2005325710 @default.
- W2770859189 cites W2005617468 @default.
- W2770859189 cites W2006844115 @default.
- W2770859189 cites W2008777486 @default.
- W2770859189 cites W2021593900 @default.
- W2770859189 cites W2023745283 @default.
- W2770859189 cites W2025492398 @default.
- W2770859189 cites W2044120077 @default.
- W2770859189 cites W2044830131 @default.
- W2770859189 cites W2045523681 @default.
- W2770859189 cites W2048786084 @default.
- W2770859189 cites W2052598541 @default.
- W2770859189 cites W2053702504 @default.
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- W2770859189 cites W2063023858 @default.
- W2770859189 cites W2063778808 @default.
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- W2770859189 cites W2070700342 @default.
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- W2770859189 cites W2073755026 @default.
- W2770859189 cites W2074324848 @default.
- W2770859189 cites W2074591015 @default.
- W2770859189 cites W2079276277 @default.
- W2770859189 cites W2088128367 @default.
- W2770859189 cites W2088142377 @default.
- W2770859189 cites W2090260381 @default.
- W2770859189 cites W2092778272 @default.
- W2770859189 cites W2093527972 @default.
- W2770859189 cites W2102512718 @default.
- W2770859189 cites W2108946209 @default.
- W2770859189 cites W2122505553 @default.
- W2770859189 cites W2127202275 @default.
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- W2770859189 cites W2138472595 @default.
- W2770859189 cites W2142482111 @default.
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- W2770859189 cites W2151870437 @default.
- W2770859189 cites W2154485230 @default.
- W2770859189 cites W2158610627 @default.
- W2770859189 cites W2161604785 @default.
- W2770859189 cites W2166185239 @default.
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- W2770859189 cites W2187208469 @default.
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- W2770859189 cites W2291475215 @default.
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- W2770859189 doi "https://doi.org/10.7554/elife.33333" @default.
- W2770859189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5708896" @default.
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