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- W2770876747 abstract "Abstract Objectives African American populations in the U.S. formed primarily by mating between Africans and Europeans over the last 500 years. To date, studies of admixture have focused on either a one‐time admixture event or continuous input into the African American population from Europeans only. Our goal is to gain a better understanding of the admixture process by examining models that take into account (a) assortative mating by ancestry in the African American population, (b) continuous input from both Europeans and Africans, and (c) historically informed variation in the rate of African migration over time. Materials and methods We used a model‐based clustering method to generate distributions of African ancestry in three samples comprised of 147 African Americans from two published sources. We used a log‐likelihood method to examine the fit of four models to these distributions and used a log‐likelihood ratio test to compare the relative fit of each model. Results The mean ancestry estimates for our datasets of 77% African/23% European to 83% African/17% European ancestry are consistent with previous studies. We find admixture models that incorporate continuous gene flow from Europeans fit significantly better than one‐time event models, and that a model involving continuous gene flow from Africans and Europeans fits better than one with continuous gene flow from Europeans only for two samples. Importantly, models that involve continuous input from Africans necessitate a higher level of gene flow from Europeans than previously reported. Discussion We demonstrate that models that take into account information about the rate of African migration over the past 500 years fit observed patterns of African ancestry better than alternative models. Our approach will enrich our understanding of the admixture process in extant and past populations." @default.
- W2770876747 created "2017-12-04" @default.
- W2770876747 creator A5050985744 @default.
- W2770876747 date "2017-11-13" @default.
- W2770876747 modified "2023-10-01" @default.
- W2770876747 title "Tests of fit of historically-informed models of African American Admixture" @default.
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- W2770876747 doi "https://doi.org/10.1002/ajpa.23343" @default.
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