Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770890085> ?p ?o ?g. }
- W2770890085 abstract "Hebbian plasticity is thought to require glutamate signalling. We show this is not the case for hippocampal presynaptic long-term potentiation (LTPpre), which is expressed as an increase in transmitter release probability (Pr). We find that LTPpre can be induced by pairing pre- and postsynaptic spiking in the absence of glutamate signalling. LTPpre induction involves a non-canonical mechanism of retrograde nitric oxide signalling, which is triggered by Ca2+ influx from L-type voltage-gated Ca2+ channels, not postsynaptic NMDA receptors (NMDARs), and does not require glutamate release. When glutamate release occurs, it decreases Pr by activating presynaptic NMDARs, and promotes presynaptic long-term depression. Net changes in Pr, therefore, depend on two opposing factors: (1) Hebbian activity, which increases Pr, and (2) glutamate release, which decreases Pr. Accordingly, release failures during Hebbian activity promote LTPpre induction. Our findings reveal a novel framework of presynaptic plasticity that radically differs from traditional models of postsynaptic plasticity." @default.
- W2770890085 created "2017-12-04" @default.
- W2770890085 creator A5012664789 @default.
- W2770890085 creator A5044861112 @default.
- W2770890085 creator A5080370935 @default.
- W2770890085 date "2017-11-15" @default.
- W2770890085 modified "2023-10-11" @default.
- W2770890085 title "Glutamate is required for depression but not potentiation of long-term presynaptic function" @default.
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