Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770951321> ?p ?o ?g. }
- W2770951321 endingPage "81" @default.
- W2770951321 startingPage "67" @default.
- W2770951321 abstract "Serine proteases have significant functions over a broad range of relevant biological processes to the Leishmania spp lifecycle. Data gathered here present an update on the Leishmania spp serine proteases and the status of these enzymes as part of the parasite degradome. The serine protease genes (n = 26 to 28) in Leishmania spp, which encode proteins with a wide range of molecular masses (35 kDa-115 kDa), are described along with their degrees of chromosomal and allelic synteny. Amid 17 putative Leishmania spp serine proteases, only ∼18% were experimentally demonstrated, as: signal peptidases that remove the signal peptide from secretory pre-proteins, maturases of other proteins and with metacaspase-like activity. These enzymes include those of clans SB, SC and SF. Classical inhibitors of serine proteases are used as tools for the characterization and investigation of Leishmania spp. Endogenous serine protease inhibitors, which are ecotin-like, can act modulating host actions. However, crude or synthetic based-natural serine protease inhibitors, such as potato tuber extract, Stichodactyla helianthus protease inhibitor I, fukugetin and epoxy-α-lapachone act on parasitic serine proteases and are promising leishmanicidal agents. The functional interrelationship between serine proteases and other Leishmania spp proteins demonstrate essential functions of these enzymes in parasite physiology and therefore their value as targets for leishmaniasis treatment." @default.
- W2770951321 created "2017-12-04" @default.
- W2770951321 creator A5008561214 @default.
- W2770951321 creator A5028288533 @default.
- W2770951321 creator A5037393418 @default.
- W2770951321 creator A5049544041 @default.
- W2770951321 creator A5059028376 @default.
- W2770951321 creator A5066705607 @default.
- W2770951321 creator A5069752916 @default.
- W2770951321 creator A5088453889 @default.
- W2770951321 date "2018-01-01" @default.
- W2770951321 modified "2023-10-16" @default.
- W2770951321 title "Understanding serine proteases implications on Leishmania spp lifecycle" @default.
- W2770951321 cites W1510296999 @default.
- W2770951321 cites W1531754583 @default.
- W2770951321 cites W1542246066 @default.
- W2770951321 cites W1598176384 @default.
- W2770951321 cites W1952065778 @default.
- W2770951321 cites W1967750282 @default.
- W2770951321 cites W1969876786 @default.
- W2770951321 cites W1970473265 @default.
- W2770951321 cites W1972314084 @default.
- W2770951321 cites W1973111776 @default.
- W2770951321 cites W1973339480 @default.
- W2770951321 cites W1975581657 @default.
- W2770951321 cites W1976502466 @default.
- W2770951321 cites W1977287683 @default.
- W2770951321 cites W1980987067 @default.
- W2770951321 cites W1984064713 @default.
- W2770951321 cites W1984075743 @default.
- W2770951321 cites W1984243890 @default.
- W2770951321 cites W1985282334 @default.
- W2770951321 cites W1985686259 @default.
- W2770951321 cites W1988542675 @default.
- W2770951321 cites W1993371274 @default.
- W2770951321 cites W1994798575 @default.
- W2770951321 cites W1997319983 @default.
- W2770951321 cites W1997603746 @default.
- W2770951321 cites W1997750876 @default.
- W2770951321 cites W2003451501 @default.
- W2770951321 cites W2004504718 @default.
- W2770951321 cites W2006037684 @default.
- W2770951321 cites W2010912389 @default.
- W2770951321 cites W2019949449 @default.
- W2770951321 cites W2020841776 @default.
- W2770951321 cites W2021393695 @default.
- W2770951321 cites W2024103566 @default.
- W2770951321 cites W2027617575 @default.
- W2770951321 cites W2027713759 @default.
- W2770951321 cites W2028751821 @default.
- W2770951321 cites W2034179284 @default.
- W2770951321 cites W2041003708 @default.
- W2770951321 cites W2045390653 @default.
- W2770951321 cites W2046793259 @default.
- W2770951321 cites W2047157924 @default.
- W2770951321 cites W2054445976 @default.
- W2770951321 cites W2056942314 @default.
- W2770951321 cites W2061415107 @default.
- W2770951321 cites W2063624527 @default.
- W2770951321 cites W2064674351 @default.
- W2770951321 cites W2065138510 @default.
- W2770951321 cites W2066506931 @default.
- W2770951321 cites W2066537174 @default.
- W2770951321 cites W2069508712 @default.
- W2770951321 cites W2072809427 @default.
- W2770951321 cites W2077195973 @default.
- W2770951321 cites W2080427880 @default.
- W2770951321 cites W2080857490 @default.
- W2770951321 cites W2086842750 @default.
- W2770951321 cites W2086866751 @default.
- W2770951321 cites W2088914912 @default.
- W2770951321 cites W2092138872 @default.
- W2770951321 cites W2092153331 @default.
- W2770951321 cites W2094126645 @default.
- W2770951321 cites W2094309012 @default.
- W2770951321 cites W2098054105 @default.
- W2770951321 cites W2100377449 @default.
- W2770951321 cites W2101572186 @default.
- W2770951321 cites W2103196178 @default.
- W2770951321 cites W2103502223 @default.
- W2770951321 cites W2104032312 @default.
- W2770951321 cites W2105029969 @default.
- W2770951321 cites W2107022019 @default.
- W2770951321 cites W2107374936 @default.
- W2770951321 cites W2112315287 @default.
- W2770951321 cites W2112949003 @default.
- W2770951321 cites W2115454786 @default.
- W2770951321 cites W2118018561 @default.
- W2770951321 cites W2120904816 @default.
- W2770951321 cites W2123394884 @default.
- W2770951321 cites W2128528345 @default.
- W2770951321 cites W2136723135 @default.
- W2770951321 cites W2137286214 @default.
- W2770951321 cites W2138846998 @default.
- W2770951321 cites W2158857856 @default.
- W2770951321 cites W2165015670 @default.
- W2770951321 cites W2170302951 @default.
- W2770951321 cites W2170551254 @default.