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• W2770967124 abstract "Two decades have passed since the discovery of the tumor suppressor, PTEN. A multitude of biological functions have since been revealed, suggesting potential therapeutic applications for both PTEN activation (e.g., cancer) and inhibition (e.g., neuroregeneration). Nevertheless, PTEN's therapeutic suitability has been called into question due to its “risky” profile as a tumor suppressor. To evaluate PTEN function and its various roles in disease a number of molecules have so far been developed. However, intrinsic problems associated with phosphatase inhibition and PTEN's complex regulation via post-translational modifications hinder straightforward access to selective modulators. For this reason, central questions associated with PTEN targeting remain unanswered. In this perspective, we summarize current PTEN-targeting strategies and discuss potential approaches to modulate its functional dose, considering all stages of PTEN biogenesis from direct protein modulation to the targeting of relevant miRNAs as well as the PTEN gene and mRNA. Two decades have passed since the discovery of the tumor suppressor, PTEN. A multitude of biological functions have since been revealed, suggesting potential therapeutic applications for both PTEN activation (e.g., cancer) and inhibition (e.g., neuroregeneration). Nevertheless, PTEN's therapeutic suitability has been called into question due to its “risky” profile as a tumor suppressor. To evaluate PTEN function and its various roles in disease a number of molecules have so far been developed. However, intrinsic problems associated with phosphatase inhibition and PTEN's complex regulation via post-translational modifications hinder straightforward access to selective modulators. For this reason, central questions associated with PTEN targeting remain unanswered. In this perspective, we summarize current PTEN-targeting strategies and discuss potential approaches to modulate its functional dose, considering all stages of PTEN biogenesis from direct protein modulation to the targeting of relevant miRNAs as well as the PTEN gene and mRNA." @default.
• W2770967124 created "2017-12-04" @default.
• W2770967124 creator A5024905171 @default.
• W2770967124 creator A5075772816 @default.
• W2770967124 creator A5087985647 @default.
• W2770967124 date "2018-01-01" @default.
• W2770967124 modified "2023-09-28" @default.
• W2770967124 title "The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein" @default.
• W2770967124 cites W1576533924 @default.
• W2770967124 cites W1648301895 @default.
• W2770967124 cites W1734521060 @default.
• W2770967124 cites W1939083266 @default.
• W2770967124 cites W1966498224 @default.
• W2770967124 cites W1966868778 @default.
• W2770967124 cites W1969040215 @default.
• W2770967124 cites W1976073141 @default.
• W2770967124 cites W1976956469 @default.
• W2770967124 cites W1977416006 @default.
• W2770967124 cites W1978062162 @default.
• W2770967124 cites W1978934025 @default.
• W2770967124 cites W1979961040 @default.
• W2770967124 cites W1980129409 @default.
• W2770967124 cites W1980309536 @default.
• W2770967124 cites W1984548348 @default.
• W2770967124 cites W1985030518 @default.
• W2770967124 cites W1985950007 @default.
• W2770967124 cites W1987967112 @default.
• W2770967124 cites W1993254773 @default.
• W2770967124 cites W1995770815 @default.
• W2770967124 cites W1996222881 @default.
• W2770967124 cites W1996788258 @default.
• W2770967124 cites W1999360191 @default.
• W2770967124 cites W1999962445 @default.
• W2770967124 cites W2000093333 @default.
• W2770967124 cites W2004538934 @default.
• W2770967124 cites W2008147081 @default.
• W2770967124 cites W2011239129 @default.
• W2770967124 cites W2013842709 @default.
• W2770967124 cites W2017739035 @default.
• W2770967124 cites W2022416092 @default.
• W2770967124 cites W2024084160 @default.
• W2770967124 cites W2030712838 @default.
• W2770967124 cites W2037301053 @default.
• W2770967124 cites W2045998598 @default.
• W2770967124 cites W2047104136 @default.
• W2770967124 cites W2048052211 @default.
• W2770967124 cites W2051118426 @default.
• W2770967124 cites W2053702806 @default.
• W2770967124 cites W2057664350 @default.
• W2770967124 cites W2057668846 @default.
• W2770967124 cites W2059281747 @default.
• W2770967124 cites W2060339369 @default.
• W2770967124 cites W2060459012 @default.
• W2770967124 cites W2060712219 @default.
• W2770967124 cites W2063776135 @default.
• W2770967124 cites W2067355824 @default.
• W2770967124 cites W2068345721 @default.
• W2770967124 cites W2070634275 @default.
• W2770967124 cites W2071030419 @default.
• W2770967124 cites W2075034454 @default.
• W2770967124 cites W2078590818 @default.
• W2770967124 cites W2084173287 @default.
• W2770967124 cites W2088707712 @default.
• W2770967124 cites W2090983338 @default.
• W2770967124 cites W2091087485 @default.
• W2770967124 cites W2092373769 @default.
• W2770967124 cites W2094215712 @default.
• W2770967124 cites W2094895270 @default.
• W2770967124 cites W2094957750 @default.
• W2770967124 cites W2095949497 @default.
• W2770967124 cites W2098318517 @default.
• W2770967124 cites W2104616895 @default.
• W2770967124 cites W2104905829 @default.
• W2770967124 cites W2105549148 @default.
• W2770967124 cites W2105685115 @default.
• W2770967124 cites W2105989397 @default.
• W2770967124 cites W2110400866 @default.
• W2770967124 cites W2110789683 @default.
• W2770967124 cites W2114000430 @default.
• W2770967124 cites W2116365126 @default.
• W2770967124 cites W2118151336 @default.
• W2770967124 cites W2119771879 @default.
• W2770967124 cites W2122234310 @default.
• W2770967124 cites W2122290210 @default.
• W2770967124 cites W2126008912 @default.
• W2770967124 cites W2127202058 @default.
• W2770967124 cites W2127325055 @default.
• W2770967124 cites W2127833933 @default.
• W2770967124 cites W2129546321 @default.
• W2770967124 cites W2133067505 @default.
• W2770967124 cites W2133814931 @default.
• W2770967124 cites W2135398049 @default.
• W2770967124 cites W2136939412 @default.
• W2770967124 cites W2137403619 @default.
• W2770967124 cites W2139939144 @default.
• W2770967124 cites W2140154966 @default.
• W2770967124 cites W2150233389 @default.
• W2770967124 cites W2150528537 @default.

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