FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770992343> ?p ?o ?g. }

• W2770992343 endingPage "518" @default.
• W2770992343 startingPage "512" @default.
• W2770992343 abstract "We have determined a functional link to the inverse expression of SETDB1 and FosB following anticancer drug treatment. Doxorubicin treatment caused decreased SETDB1 expression and FosB overexpression both at the mRNA and protein levels. The decreased HMTase activity of SETDB1 coincided with altered occupancy across the promoter region of the FosB gene. SETDB1 overexpression decreased the luciferase reporter activity containing the FosB promoter region, but siSETDB1 increased the luciferase reporter activity, suggesting that SETDB1 directly and negatively regulated FosB expression. In addition, MEK inhibitor (PD98059) blocked the SETDB1 regulation of the FosB promoter activity via ERK2 activation during doxorubicin treatment. A microscopic analysis reveals that FosB expression was observed in living cells in spite of doxorubicin treatment. Ectopic FosB/ΔFosB expression increased the number of colonies and the migration of A549 cells compared to that in control. These results suggest that the ERK2-SETDB1-FosB signaling pathway might have an anti-therapeutic regulatory mechanism that increases the transformation and migration activity of cancer cells during anticancer drug treatment." @default.
• W2770992343 created "2017-12-04" @default.
• W2770992343 creator A5042657449 @default.
• W2770992343 creator A5073981096 @default.
• W2770992343 date "2018-01-01" @default.
• W2770992343 modified "2023-09-24" @default.
• W2770992343 title "SETDB1-mediated FosB regulation via ERK2 is associated with an increase in cell invasiveness during anticancer drug treatment of A549 human lung cancer cells" @default.
• W2770992343 cites W1500897968 @default.
• W2770992343 cites W1901004393 @default.
• W2770992343 cites W1976155578 @default.
• W2770992343 cites W1979667448 @default.
• W2770992343 cites W1991583617 @default.
• W2770992343 cites W1995128516 @default.
• W2770992343 cites W2036670951 @default.
• W2770992343 cites W2048536145 @default.
• W2770992343 cites W2050019055 @default.
• W2770992343 cites W2057117594 @default.
• W2770992343 cites W2061606125 @default.
• W2770992343 cites W2071147743 @default.
• W2770992343 cites W2074329146 @default.
• W2770992343 cites W2075013638 @default.
• W2770992343 cites W2080907328 @default.
• W2770992343 cites W2124302786 @default.
• W2770992343 cites W2128627710 @default.
• W2770992343 cites W2151026121 @default.
• W2770992343 cites W2261840500 @default.
• W2770992343 cites W2295492909 @default.
• W2770992343 cites W2300008111 @default.
• W2770992343 cites W2507610324 @default.
• W2770992343 cites W2520343687 @default.
• W2770992343 cites W2528695280 @default.
• W2770992343 cites W2530407019 @default.
• W2770992343 cites W2575789714 @default.
• W2770992343 cites W2593675727 @default.
• W2770992343 doi "https://doi.org/10.1016/j.bbrc.2017.10.176" @default.
• W2770992343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29108991" @default.
• W2770992343 hasPublicationYear "2018" @default.
• W2770992343 type Work @default.
• W2770992343 sameAs 2770992343 @default.
• W2770992343 citedByCount "12" @default.
• W2770992343 countsByYear W27709923432019 @default.
• W2770992343 countsByYear W27709923432020 @default.
• W2770992343 countsByYear W27709923432021 @default.
• W2770992343 countsByYear W27709923432022 @default.
• W2770992343 crossrefType "journal-article" @default.
• W2770992343 hasAuthorship W2770992343A5042657449 @default.
• W2770992343 hasAuthorship W2770992343A5073981096 @default.
• W2770992343 hasConcept C104317684 @default.
• W2770992343 hasConcept C111335760 @default.
• W2770992343 hasConcept C119056186 @default.
• W2770992343 hasConcept C1491633281 @default.
• W2770992343 hasConcept C150194340 @default.
• W2770992343 hasConcept C153911025 @default.
• W2770992343 hasConcept C185592680 @default.
• W2770992343 hasConcept C2776694085 @default.
• W2770992343 hasConcept C2777099045 @default.
• W2770992343 hasConcept C2781303535 @default.
• W2770992343 hasConcept C502942594 @default.
• W2770992343 hasConcept C54009773 @default.
• W2770992343 hasConcept C54355233 @default.
• W2770992343 hasConcept C55493867 @default.
• W2770992343 hasConcept C81729549 @default.
• W2770992343 hasConcept C81885089 @default.
• W2770992343 hasConcept C86803240 @default.
• W2770992343 hasConcept C95444343 @default.
• W2770992343 hasConcept C97037327 @default.
• W2770992343 hasConceptScore W2770992343C104317684 @default.
• W2770992343 hasConceptScore W2770992343C111335760 @default.
• W2770992343 hasConceptScore W2770992343C119056186 @default.
• W2770992343 hasConceptScore W2770992343C1491633281 @default.
• W2770992343 hasConceptScore W2770992343C150194340 @default.
• W2770992343 hasConceptScore W2770992343C153911025 @default.
• W2770992343 hasConceptScore W2770992343C185592680 @default.
• W2770992343 hasConceptScore W2770992343C2776694085 @default.
• W2770992343 hasConceptScore W2770992343C2777099045 @default.
• W2770992343 hasConceptScore W2770992343C2781303535 @default.
• W2770992343 hasConceptScore W2770992343C502942594 @default.
• W2770992343 hasConceptScore W2770992343C54009773 @default.
• W2770992343 hasConceptScore W2770992343C54355233 @default.
• W2770992343 hasConceptScore W2770992343C55493867 @default.
• W2770992343 hasConceptScore W2770992343C81729549 @default.
• W2770992343 hasConceptScore W2770992343C81885089 @default.
• W2770992343 hasConceptScore W2770992343C86803240 @default.
• W2770992343 hasConceptScore W2770992343C95444343 @default.
• W2770992343 hasConceptScore W2770992343C97037327 @default.
• W2770992343 hasFunder F4320322120 @default.
• W2770992343 hasIssue "1" @default.
• W2770992343 hasLocation W27709923431 @default.
• W2770992343 hasLocation W27709923432 @default.
• W2770992343 hasOpenAccess W2770992343 @default.
• W2770992343 hasPrimaryLocation W27709923431 @default.
• W2770992343 hasRelatedWork W1733527712 @default.
• W2770992343 hasRelatedWork W1976223100 @default.
• W2770992343 hasRelatedWork W2055256213 @default.
• W2770992343 hasRelatedWork W2351429383 @default.
• W2770992343 hasRelatedWork W2437272087 @default.
• W2770992343 hasRelatedWork W2562091852 @default.
• W2770992343 hasRelatedWork W2604918044 @default.

• next