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• W2771009958 abstract "This study evaluated the frequency and long-term dynamics of early and late post irradiation damage after proton-photon or photon therapy for locally advanced prostate cancer.The results of a randomized study of proton-photon or photon therapy using several fractionation regimes were analyzed in 272 patients with high and intermediate risk of progression.Three variants of proton boost fractionation were studied sequentially: 3.0 (8 daily fractions), 4.0 (5 fractions, 3 or 5 fractions/week), and 5.5 (3 fractions, 3 fractions/week) Gy(RBE).A significant decrease in the severity of both acute and late gastrointestinal injuries is achievable with a proton beam. The dynamics of late gastrointestinal and genitourinary toxicity over a 10-year period were generally characterized by a decrease in severity of morbidity by 30% and 15%, respectively.Local irradiation with a fractional dose of 3.0-5.5 Gy(RBE) and a cumulative dose of 28.0-28.8 Gy(RBE) for protons significantly reduces the early and late rectitis severity, but does not reduce the risk of lower urinary tract injuries. Fractionation regimens do not significantly differ in toxicity levels." @default.
• W2771009958 created "2017-12-04" @default.
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• W2771009958 date "2018-01-01" @default.
• W2771009958 modified "2023-09-24" @default.
• W2771009958 title "Morbidity dynamics in proton–photon or photon radiation therapy for locally advanced prostate cancer" @default.
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• W2771009958 doi "https://doi.org/10.1016/j.rpor.2017.11.001" @default.
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