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- W2771058451 abstract "Members of the family Filoviridae cause severe, often fatal disease in humans, for which there are no approved vaccines and only a few experimental drugs tested in animal models. Retro-2, a small molecule that inhibits retrograde trafficking of bacterial and plant toxins inside host cells, has been demonstrated to be effective against a range of bacterial and virus pathogens, both in vitro and in animal models. Here, we demonstrated that Retro-2 and its derivatives, Retro-2.1 and compound 25, blocked infection by Ebola virus and Marburg virus in vitro. We show that the derivatives were more potent inhibitors of infection as compared to the parent compound. Pseudotyped virus assays indicated that the compounds affected virus entry into cells while virus particle localization to Niemann-Pick C1-positive compartments showed that they acted at a late step in virus entry. Our work demonstrates a potential for Retro-type drugs to be developed into anti-filoviral therapeutics." @default.
- W2771058451 created "2017-12-04" @default.
- W2771058451 creator A5015632966 @default.
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- W2771058451 date "2018-01-01" @default.
- W2771058451 modified "2023-09-25" @default.
- W2771058451 title "Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection" @default.
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- W2771058451 doi "https://doi.org/10.1016/j.antiviral.2017.11.016" @default.
- W2771058451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29175127" @default.
- W2771058451 hasPublicationYear "2018" @default.
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