Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771095710> ?p ?o ?g. }
- W2771095710 endingPage "683" @default.
- W2771095710 startingPage "673" @default.
- W2771095710 abstract "Few tools are available for noninvasive imaging of synapses in the living mammalian brain. Current paradigms require the use of genetically modified mice or viral delivery of genetic material to the brain. To develop an alternative chemical approach, utilizing the recognition of synaptic components by organic small molecules, we designed an imaging-based, high-content screen in cultured cortical neurons to identify molecules based on their colocalization with fluorescently tagged synaptic proteins. We used this approach to screen a library of ∼7000 novel fluorescent dyes, and identified a series of compounds in the xanthone family that exhibited consistent synaptic labeling. Follow-up studies with one of these compounds, CX-G3, demonstrated its ability to label acidic organelles and in particular synaptic vesicles at glutamatergic synapses in cultured neurons and murine brain tissue, indicating the potential of this screening approach to identify promising lead compounds for use as synaptic markers, sensors, and targeting devices." @default.
- W2771095710 created "2017-12-22" @default.
- W2771095710 creator A5001055290 @default.
- W2771095710 creator A5003209063 @default.
- W2771095710 creator A5016010299 @default.
- W2771095710 creator A5021452033 @default.
- W2771095710 creator A5024642648 @default.
- W2771095710 creator A5026386775 @default.
- W2771095710 creator A5026787858 @default.
- W2771095710 creator A5027288517 @default.
- W2771095710 creator A5051567864 @default.
- W2771095710 creator A5054228916 @default.
- W2771095710 creator A5064385465 @default.
- W2771095710 creator A5067886773 @default.
- W2771095710 creator A5075273861 @default.
- W2771095710 creator A5077209777 @default.
- W2771095710 date "2017-12-07" @default.
- W2771095710 modified "2023-10-15" @default.
- W2771095710 title "Identification of Fluorescent Small Molecule Compounds for Synaptic Labeling by Image-Based, High-Content Screening" @default.
- W2771095710 cites W103672796 @default.
- W2771095710 cites W1168911763 @default.
- W2771095710 cites W1965419928 @default.
- W2771095710 cites W2000888419 @default.
- W2771095710 cites W2009066857 @default.
- W2771095710 cites W2009340441 @default.
- W2771095710 cites W2014603223 @default.
- W2771095710 cites W2021512296 @default.
- W2771095710 cites W2031220002 @default.
- W2771095710 cites W2032909563 @default.
- W2771095710 cites W2042572088 @default.
- W2771095710 cites W2062764435 @default.
- W2771095710 cites W2069242625 @default.
- W2771095710 cites W2070765829 @default.
- W2771095710 cites W2074718033 @default.
- W2771095710 cites W2083858798 @default.
- W2771095710 cites W2086028774 @default.
- W2771095710 cites W2096689006 @default.
- W2771095710 cites W2098229885 @default.
- W2771095710 cites W2105895439 @default.
- W2771095710 cites W2115086384 @default.
- W2771095710 cites W2117389654 @default.
- W2771095710 cites W2120551490 @default.
- W2771095710 cites W2124733101 @default.
- W2771095710 cites W2127270677 @default.
- W2771095710 cites W2127394218 @default.
- W2771095710 cites W2137951079 @default.
- W2771095710 cites W2140698933 @default.
- W2771095710 cites W2142768012 @default.
- W2771095710 cites W2171332611 @default.
- W2771095710 cites W2287361610 @default.
- W2771095710 cites W2304380155 @default.
- W2771095710 cites W2509350040 @default.
- W2771095710 cites W2540936054 @default.
- W2771095710 cites W2753434084 @default.
- W2771095710 doi "https://doi.org/10.1021/acschemneuro.7b00263" @default.
- W2771095710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29215865" @default.
- W2771095710 hasPublicationYear "2017" @default.
- W2771095710 type Work @default.
- W2771095710 sameAs 2771095710 @default.
- W2771095710 citedByCount "5" @default.
- W2771095710 countsByYear W27710957102019 @default.
- W2771095710 countsByYear W27710957102020 @default.
- W2771095710 countsByYear W27710957102021 @default.
- W2771095710 countsByYear W27710957102022 @default.
- W2771095710 countsByYear W27710957102023 @default.
- W2771095710 crossrefType "journal-article" @default.
- W2771095710 hasAuthorship W2771095710A5001055290 @default.
- W2771095710 hasAuthorship W2771095710A5003209063 @default.
- W2771095710 hasAuthorship W2771095710A5016010299 @default.
- W2771095710 hasAuthorship W2771095710A5021452033 @default.
- W2771095710 hasAuthorship W2771095710A5024642648 @default.
- W2771095710 hasAuthorship W2771095710A5026386775 @default.
- W2771095710 hasAuthorship W2771095710A5026787858 @default.
- W2771095710 hasAuthorship W2771095710A5027288517 @default.
- W2771095710 hasAuthorship W2771095710A5051567864 @default.
- W2771095710 hasAuthorship W2771095710A5054228916 @default.
- W2771095710 hasAuthorship W2771095710A5064385465 @default.
- W2771095710 hasAuthorship W2771095710A5067886773 @default.
- W2771095710 hasAuthorship W2771095710A5075273861 @default.
- W2771095710 hasAuthorship W2771095710A5077209777 @default.
- W2771095710 hasBestOaLocation W27710957102 @default.
- W2771095710 hasConcept C121332964 @default.
- W2771095710 hasConcept C127445978 @default.
- W2771095710 hasConcept C130316041 @default.
- W2771095710 hasConcept C148785051 @default.
- W2771095710 hasConcept C169760540 @default.
- W2771095710 hasConcept C170493617 @default.
- W2771095710 hasConcept C185592680 @default.
- W2771095710 hasConcept C200170125 @default.
- W2771095710 hasConcept C2780648746 @default.
- W2771095710 hasConcept C40209533 @default.
- W2771095710 hasConcept C41625074 @default.
- W2771095710 hasConcept C55493867 @default.
- W2771095710 hasConcept C61174792 @default.
- W2771095710 hasConcept C62520636 @default.
- W2771095710 hasConcept C86803240 @default.
- W2771095710 hasConcept C91881484 @default.
- W2771095710 hasConcept C95444343 @default.