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• W2771105938 endingPage "464" @default.
• W2771105938 startingPage "455" @default.
• W2771105938 abstract "Trabecular bone structure is crucial to normal mechanical behavior of bones. Studies have shown that osteoporosis negatively affects trabecular bone structure, mainly by reducing bone volume fraction (BV/TV) and thus increasing fracture risk. One major limitation in assessing and quantifying the effect of this structural deterioration is that no two trabecular structures are identical. Thus, when we compare a group of healthy bones against a different group of bones that experienced resorption (i.e. decreased BV/TV) we only discover an average mechanical effect. It is impossible to quantify the mechanical effect of individual structural deterioration for each sample, simply because we never have the same sample in both states (intact and deteriorated structure). 3D printing is a new technology that can assist in overcoming this issue. Here we report a preliminary study that compares a healthy 3D printed trabecular bone model with the same model after bone resorption was simulated. Since the deteriorated structural bone model is derived from the healthy one, it is possible to directly estimate (percentage wise) the decrease of tissue stiffness and strength as a result of bone resorption for this specific structure. Our results demonstrate that a relatively small decrease in BV/TV (about 8%) leads to a dramatic decrease in structural strength (24%) and structural stiffness (17%), (P < 0.01). Structural strength decreased from an average of 9.14 ± 2.85MPa to 6.97 ± 2.44MPa, while structural stiffness decreased from an average of 282.5 ± 63.4N/mm to 233.8 ± 51.2N/mm. This study demonstrates that 3D printing is a novel and valuable tool for quantifying the effect of structural deterioration on the mechanical properties of trabecular bone. In the future, this approach may help us attain better personal fracture risk assessments by CT scanning, 3D printing and mechanically testing individual bone replicas from patients suffering excessive bone resorption." @default.
• W2771105938 created "2017-12-22" @default.
• W2771105938 creator A5002353248 @default.
• W2771105938 creator A5049439573 @default.
• W2771105938 date "2018-02-01" @default.
• W2771105938 modified "2023-09-27" @default.
• W2771105938 title "A novel use of 3D printing model demonstrates the effects of deteriorated trabecular bone structure on bone stiffness and strength" @default.
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• W2771105938 doi "https://doi.org/10.1016/j.jmbbm.2017.12.010" @default.
• W2771105938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5758409" @default.
• W2771105938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29241149" @default.
• W2771105938 hasPublicationYear "2018" @default.
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