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- W2771119295 endingPage "14" @default.
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- W2771119295 abstract "Most estrogen-based hormone therapies are administered in combination with a progestogen, such as Levonorgestrel (Levo). Individually, the estrogen 17β-estradiol (E2) and Levo can improve cognition in preclinical models. However, although these hormones are often given together clinically, the impact of the E2 + Levo combination on cognitive function has yet to be methodically examined. Thus, we investigated E2 + Levo treatment on a cognitive battery in middle-aged, ovariectomized rats. When administered alone, E2 and Levo treatments each enhanced spatial working memory relative to vehicle treatment, whereas the E2 + Levo combination impaired high working memory load performance relative to E2 only and Levo only treatments. There were no effects on spatial reference memory. Mitogen-activated protein kinases/extracellular signal-regulated kinases pathway activation, which is involved in memory formation and estrogen-induced memory effects, was evaluated in 5 brain regions implicated in learning and memory. A distinct relationship was seen in the E2-only treatment group between mitogen-activated protein kinases/extracellular signal-regulated kinases pathway activation in the frontal cortex and working memory performance. Collectively, the results indicate that the differential neurocognitive effects of combination versus sole treatments are vital considerations as we move forward as a field to develop novel, and to understand currently used, exogenous hormone regimens across the lifespan." @default.
- W2771119295 created "2017-12-22" @default.
- W2771119295 creator A5006414984 @default.
- W2771119295 creator A5008989514 @default.
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- W2771119295 creator A5046405317 @default.
- W2771119295 creator A5053392472 @default.
- W2771119295 creator A5064687927 @default.
- W2771119295 date "2018-04-01" @default.
- W2771119295 modified "2023-10-17" @default.
- W2771119295 title "Contrasting effects of individual versus combined estrogen and progestogen regimens as working memory load increases in middle-aged ovariectomized rats: one plus one does not equal two" @default.
- W2771119295 cites W1523245177 @default.
- W2771119295 cites W1968470615 @default.
- W2771119295 cites W1973023891 @default.
- W2771119295 cites W1976606440 @default.
- W2771119295 cites W1982221175 @default.
- W2771119295 cites W1983155363 @default.
- W2771119295 cites W1984242980 @default.
- W2771119295 cites W2002090514 @default.
- W2771119295 cites W2002140984 @default.
- W2771119295 cites W2005139532 @default.
- W2771119295 cites W2005356261 @default.
- W2771119295 cites W2006377495 @default.
- W2771119295 cites W2009343153 @default.
- W2771119295 cites W2009374844 @default.
- W2771119295 cites W2014190906 @default.
- W2771119295 cites W2016978785 @default.
- W2771119295 cites W2019359367 @default.
- W2771119295 cites W2021003502 @default.
- W2771119295 cites W2029817026 @default.
- W2771119295 cites W2032133490 @default.
- W2771119295 cites W2032281827 @default.
- W2771119295 cites W2032679733 @default.
- W2771119295 cites W2032843033 @default.
- W2771119295 cites W2035956425 @default.
- W2771119295 cites W2042666490 @default.
- W2771119295 cites W2045668700 @default.
- W2771119295 cites W2047343829 @default.
- W2771119295 cites W2050726283 @default.
- W2771119295 cites W2054091180 @default.
- W2771119295 cites W2054223324 @default.
- W2771119295 cites W2054420201 @default.
- W2771119295 cites W2055830074 @default.
- W2771119295 cites W2058056109 @default.
- W2771119295 cites W2060859746 @default.
- W2771119295 cites W2064016146 @default.
- W2771119295 cites W2064200220 @default.
- W2771119295 cites W2068972835 @default.
- W2771119295 cites W2070458167 @default.
- W2771119295 cites W2070752385 @default.
- W2771119295 cites W2073783421 @default.
- W2771119295 cites W2074561168 @default.
- W2771119295 cites W2076133150 @default.
- W2771119295 cites W2079118147 @default.
- W2771119295 cites W2080979269 @default.
- W2771119295 cites W2084425006 @default.
- W2771119295 cites W2096291779 @default.
- W2771119295 cites W2101626807 @default.
- W2771119295 cites W2102981966 @default.
- W2771119295 cites W2104231345 @default.
- W2771119295 cites W2109009798 @default.
- W2771119295 cites W2112457093 @default.
- W2771119295 cites W2119453754 @default.
- W2771119295 cites W2123624041 @default.
- W2771119295 cites W2128081823 @default.
- W2771119295 cites W2130632811 @default.
- W2771119295 cites W2131266318 @default.
- W2771119295 cites W2132802598 @default.
- W2771119295 cites W2135910109 @default.
- W2771119295 cites W2137007429 @default.
- W2771119295 cites W2140445777 @default.
- W2771119295 cites W2143742981 @default.
- W2771119295 cites W2144213081 @default.
- W2771119295 cites W2146595381 @default.
- W2771119295 cites W2150633281 @default.
- W2771119295 cites W2155552555 @default.
- W2771119295 cites W2157544511 @default.
- W2771119295 cites W2157774774 @default.
- W2771119295 cites W2158520770 @default.
- W2771119295 cites W2158723294 @default.
- W2771119295 cites W2164589456 @default.
- W2771119295 cites W2167868515 @default.
- W2771119295 cites W2312997768 @default.
- W2771119295 cites W2329905406 @default.
- W2771119295 cites W2338598306 @default.
- W2771119295 cites W2390076498 @default.
- W2771119295 cites W2406452656 @default.
- W2771119295 cites W2467383487 @default.
- W2771119295 cites W2492914318 @default.
- W2771119295 cites W2543182494 @default.
- W2771119295 cites W2559896921 @default.
- W2771119295 cites W2562329978 @default.
- W2771119295 cites W2569968042 @default.
- W2771119295 cites W317238995 @default.
- W2771119295 cites W4230454755 @default.