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• W2771153738 abstract "Biosimilars are products that are similar in terms of quality, safety, and efficacy to an already licensed reference/ innovator product and are expected to offer improved affordability. The most significant source of reduction in the cost of development of a biosimilar is the reduced clinical examination that it is expected to undergo as compared to the innovator product. However, this clinical relief is predicated on the assumption that there is analytical similarity between the biosimilar and the innovator product. As a result, establishing analytical similarity is arguably the most important step towards successful development of a biosimilar. Here, we present results from an analytical similarity exercise that was performed with five biosimilars of rituximab (Ristova®, Roche), a chimeric mouse/ human monoclonal antibody biotherapeutic, that are available on the Indian market. The results show that, while the biosimilars exhibited similarity with respect to protein structure and function, there were significant differences with respect to size heterogeneity, charge heterogeneity and glycosylation pattern." @default.
• W2771153738 created "2017-12-22" @default.
• W2771153738 creator A5010715626 @default.
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• W2771153738 date "2017-12-07" @default.
• W2771153738 modified "2023-10-16" @default.
• W2771153738 title "Assessment of structural and functional similarity of biosimilar products: Rituximab as a case study" @default.
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• W2771153738 doi "https://doi.org/10.1080/19420862.2017.1402996" @default.
• W2771153738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5800382" @default.
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