FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771160419> ?p ?o ?g. }

• W2771160419 endingPage "160" @default.
• W2771160419 startingPage "151" @default.
• W2771160419 abstract "β-N-methylamino-l-alanine (L-BMAA) is produced by cyanobacteria (blue-green algae). Human exposure to L-BMAA occurs via consumption of L-BMAA-contaminated water and food. It is speculated that exposure to L-BMAA, and subsequent brain accumulation, may contribute to an increased incidence of neurodegenerative diseases indicating the need to evaluate risk of L-BMAA exposure to humans. As an initial step in this process, we have evaluated disposition following a single or repeated gavage administration of 1, 10 or 100mg/kg [14C]L-BMAA in rats and mice. L-BMAA was well absorbed following a single gavage administration with minimal dose, species, or sex-related effect. In both species, the main excretion route was as exhaled CO2 (46-61%) with 7-13% and 1.4-8% of the administered dose excreted in the urine and feces, respectively. L-BMAA was distributed to all tissues examined; the total radioactivity in tissues increased with the dose and was significant in both species (8-20%). In male rats, L-BMAA was slowly eliminated from blood and tissues (half-lives ≥48h). Following 1, 5 and 10days of dosing in male rats, levels in tissues increased with the number of doses demonstrating potential for accumulation of BMAA-derived equivalents. There was no greater affinity for accumulation in the brain compared to other organs and tissues. Following repeated exposure in rats, amino acid mass shifts associated with L-BMAA were detected in brain peptides. However, the low frequency of occurrence suggests that the substitution of an amino acid with L-BMAA is not significant relative to substitutions and/or modifications by other L-BMAA-derived equivalents." @default.
• W2771160419 created "2017-12-22" @default.
• W2771160419 creator A5001329019 @default.
• W2771160419 creator A5008469448 @default.
• W2771160419 creator A5027078971 @default.
• W2771160419 creator A5048616249 @default.
• W2771160419 creator A5078271521 @default.
• W2771160419 creator A5079260165 @default.
• W2771160419 creator A5083775326 @default.
• W2771160419 date "2018-01-01" @default.
• W2771160419 modified "2023-09-27" @default.
• W2771160419 title "Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure" @default.
• W2771160419 cites W1112985903 @default.
• W2771160419 cites W1485714792 @default.
• W2771160419 cites W1557014338 @default.
• W2771160419 cites W1970484692 @default.
• W2771160419 cites W1971449188 @default.
• W2771160419 cites W1972461837 @default.
• W2771160419 cites W1976168374 @default.
• W2771160419 cites W1979264461 @default.
• W2771160419 cites W1980046499 @default.
• W2771160419 cites W1987626863 @default.
• W2771160419 cites W1992114982 @default.
• W2771160419 cites W1992757367 @default.
• W2771160419 cites W1994010840 @default.
• W2771160419 cites W1994286733 @default.
• W2771160419 cites W1999403315 @default.
• W2771160419 cites W2000643475 @default.
• W2771160419 cites W2003279745 @default.
• W2771160419 cites W2012520773 @default.
• W2771160419 cites W2025541331 @default.
• W2771160419 cites W2027431416 @default.
• W2771160419 cites W2034021935 @default.
• W2771160419 cites W2037457100 @default.
• W2771160419 cites W2049773630 @default.
• W2771160419 cites W2051025140 @default.
• W2771160419 cites W2052019122 @default.
• W2771160419 cites W2061312262 @default.
• W2771160419 cites W2064654709 @default.
• W2771160419 cites W2066392481 @default.
• W2771160419 cites W2067849574 @default.
• W2771160419 cites W2070995531 @default.
• W2771160419 cites W2074614450 @default.
• W2771160419 cites W2079554923 @default.
• W2771160419 cites W2082382304 @default.
• W2771160419 cites W2088795842 @default.
• W2771160419 cites W2090141827 @default.
• W2771160419 cites W2091188688 @default.
• W2771160419 cites W2091825435 @default.
• W2771160419 cites W2092620685 @default.
• W2771160419 cites W2093137257 @default.
• W2771160419 cites W2093888943 @default.
• W2771160419 cites W2105896253 @default.
• W2771160419 cites W2110097095 @default.
• W2771160419 cites W2112148169 @default.
• W2771160419 cites W2130520300 @default.
• W2771160419 cites W2136360177 @default.
• W2771160419 cites W2143762207 @default.
• W2771160419 cites W2155348252 @default.
• W2771160419 cites W2160273235 @default.
• W2771160419 cites W2280807903 @default.
• W2771160419 cites W2292371387 @default.
• W2771160419 cites W2323000829 @default.
• W2771160419 cites W2547254640 @default.
• W2771160419 cites W2555342068 @default.
• W2771160419 cites W2584273405 @default.
• W2771160419 cites W2594895388 @default.
• W2771160419 cites W2622563719 @default.
• W2771160419 doi "https://doi.org/10.1016/j.taap.2017.12.008" @default.
• W2771160419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29248465" @default.
• W2771160419 hasPublicationYear "2018" @default.
• W2771160419 type Work @default.
• W2771160419 sameAs 2771160419 @default.
• W2771160419 citedByCount "13" @default.
• W2771160419 countsByYear W27711604192018 @default.
• W2771160419 countsByYear W27711604192019 @default.
• W2771160419 countsByYear W27711604192020 @default.
• W2771160419 countsByYear W27711604192021 @default.
• W2771160419 countsByYear W27711604192022 @default.
• W2771160419 crossrefType "journal-article" @default.
• W2771160419 hasAuthorship W2771160419A5001329019 @default.
• W2771160419 hasAuthorship W2771160419A5008469448 @default.
• W2771160419 hasAuthorship W2771160419A5027078971 @default.
• W2771160419 hasAuthorship W2771160419A5048616249 @default.
• W2771160419 hasAuthorship W2771160419A5078271521 @default.
• W2771160419 hasAuthorship W2771160419A5079260165 @default.
• W2771160419 hasAuthorship W2771160419A5083775326 @default.
• W2771160419 hasConcept C10146269 @default.
• W2771160419 hasConcept C126322002 @default.
• W2771160419 hasConcept C150903083 @default.
• W2771160419 hasConcept C185592680 @default.
• W2771160419 hasConcept C207001950 @default.
• W2771160419 hasConcept C2779669040 @default.
• W2771160419 hasConcept C2779856020 @default.
• W2771160419 hasConcept C2780026642 @default.
• W2771160419 hasConcept C2780358027 @default.
• W2771160419 hasConcept C29730261 @default.
• W2771160419 hasConcept C515207424 @default.

• next