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• W2771185679 abstract "This study aimed at studying the potential neuroprotective effect of Rutin hydrate (RH) alone or in conjugation with α-tocopherol against cadmium chloride (CdCl2)-induced neurotoxicity and cognitive impairment in rats and to investigate the mechanisms of action. Rats intoxicated with CdCl2 were treated with the vehicle, RH, α-tocopherol or combined treatment were examined, and compared to control rats received vehicle or individual doses of either drug. Data confirmed that RH improves spatial memory function by increasing acetylcholine availability, boosting endogenous antioxidant potential, activating cell survival and inhibiting apoptotic pathways, an effect that is more effective when RH was conjugated with α-tocopherol. Mechanism of RH action includes activation of PP2A mediated inhibiting of ERK1/2 and JNK apoptotic pathways and inhibition of PTEN mediated activation of mTOR survival pathway. In conclusion, RH affords a potent neuroprotection against CdCl2-induced brain damage and memory dysfunction and co-administration of α-tocopherol enhances its activity." @default.
• W2771185679 created "2017-12-22" @default.
• W2771185679 creator A5022191088 @default.
• W2771185679 creator A5062558711 @default.
• W2771185679 date "2017-12-07" @default.
• W2771185679 modified "2023-09-30" @default.
• W2771185679 title "Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling" @default.
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• W2771185679 doi "https://doi.org/10.1080/13813455.2017.1411370" @default.
• W2771185679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29214892" @default.
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