FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771196527> ?p ?o ?g. }

• W2771196527 endingPage "5446" @default.
• W2771196527 startingPage "5441" @default.
• W2771196527 abstract "Cudratricusxanthone A (CTXA), a natural bioactive compound extracted from the roots of Cudraniatricuspidata Bureau, is known to possess antithrombotic, antiproliferative, and antiinflammatory activities. It remains unclear that CTXA can improve hepatoprotective activity in vivo. The objective of this study was to investigate the effect of CTXA on lipopolysaccharide (LPS)‐induced liver failure in mice, and to elucidate its underlying molecular mechanisms. Liver failure was induced by LPS (15 mg/kg, i.p .) in mice, and 12 hr later, they were treated intravenously with CTXA. Administration of LPS significantly increased mortality, serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and serum inflammatory cytokines. CTXA treatment effectively countered these effects of LPS. Further, LPS treatment markedly increased the expression of myeloperoxidase, phosphorylation of p38, extracellular signal‐regulated kinase (ERK), and c‐Jun N‐terminal kinase (JNK), and expressions of nuclear proteins, such as nuclear factor (NF)‐κB and phosphorylated c‐Jun. Additionally, LPS increased the serum levels of tumor necrosis factor (TNF)‐α and interleukin (IL)‐6. All these effects of LPS were attenuated by CTXA. Moreover, CTXA increased the expression of sirtuin‐1 (SIRT1) and reduced the expression of acetylated forkhead box O1 box O1 (Ac‐FoxO1), acetylated Ac‐p53, and acetylated nuclear factor‐kappa beta (Ac‐NF‐κB). In conclusion, CTXA alleviates LPS‐induced liver injury by reducing inflammatory responses and the potential mechanism is associated with SIRT1 signaling activation and finally could be used to treat liver diseases." @default.
• W2771196527 created "2017-12-22" @default.
• W2771196527 creator A5034268961 @default.
• W2771196527 creator A5036343292 @default.
• W2771196527 creator A5042655034 @default.
• W2771196527 creator A5054602576 @default.
• W2771196527 creator A5071287711 @default.
• W2771196527 date "2018-01-23" @default.
• W2771196527 modified "2023-10-15" @default.
• W2771196527 title "Cudratricusxanthone A attenuates sepsis‐induced liver injury via SIRT1 signaling" @default.
• W2771196527 cites W1542964065 @default.
• W2771196527 cites W1543963511 @default.
• W2771196527 cites W1618689793 @default.
• W2771196527 cites W1926960484 @default.
• W2771196527 cites W1963778880 @default.
• W2771196527 cites W1977351943 @default.
• W2771196527 cites W1979363274 @default.
• W2771196527 cites W2000653090 @default.
• W2771196527 cites W2002469066 @default.
• W2771196527 cites W2003080985 @default.
• W2771196527 cites W2008708162 @default.
• W2771196527 cites W2012365838 @default.
• W2771196527 cites W2014973641 @default.
• W2771196527 cites W2026032500 @default.
• W2771196527 cites W2028048944 @default.
• W2771196527 cites W2048536138 @default.
• W2771196527 cites W2081084980 @default.
• W2771196527 cites W2114102299 @default.
• W2771196527 cites W2169581734 @default.
• W2771196527 cites W2506788154 @default.
• W2771196527 cites W2677579291 @default.
• W2771196527 doi "https://doi.org/10.1002/jcp.26390" @default.
• W2771196527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29226969" @default.
• W2771196527 hasPublicationYear "2018" @default.
• W2771196527 type Work @default.
• W2771196527 sameAs 2771196527 @default.
• W2771196527 citedByCount "16" @default.
• W2771196527 countsByYear W27711965272018 @default.
• W2771196527 countsByYear W27711965272019 @default.
• W2771196527 countsByYear W27711965272021 @default.
• W2771196527 countsByYear W27711965272022 @default.
• W2771196527 countsByYear W27711965272023 @default.
• W2771196527 crossrefType "journal-article" @default.
• W2771196527 hasAuthorship W2771196527A5034268961 @default.
• W2771196527 hasAuthorship W2771196527A5036343292 @default.
• W2771196527 hasAuthorship W2771196527A5042655034 @default.
• W2771196527 hasAuthorship W2771196527A5054602576 @default.
• W2771196527 hasAuthorship W2771196527A5071287711 @default.
• W2771196527 hasConcept C104317684 @default.
• W2771196527 hasConcept C126322002 @default.
• W2771196527 hasConcept C127561419 @default.
• W2771196527 hasConcept C134018914 @default.
• W2771196527 hasConcept C160160445 @default.
• W2771196527 hasConcept C164027704 @default.
• W2771196527 hasConcept C17991360 @default.
• W2771196527 hasConcept C181199279 @default.
• W2771196527 hasConcept C184235292 @default.
• W2771196527 hasConcept C185592680 @default.
• W2771196527 hasConcept C2776536020 @default.
• W2771196527 hasConcept C2776637226 @default.
• W2771196527 hasConcept C2776877979 @default.
• W2771196527 hasConcept C2776914184 @default.
• W2771196527 hasConcept C2777730290 @default.
• W2771196527 hasConcept C2778754761 @default.
• W2771196527 hasConcept C2779679107 @default.
• W2771196527 hasConcept C51551487 @default.
• W2771196527 hasConcept C55493867 @default.
• W2771196527 hasConcept C57074206 @default.
• W2771196527 hasConcept C62478195 @default.
• W2771196527 hasConcept C71924100 @default.
• W2771196527 hasConcept C98274493 @default.
• W2771196527 hasConceptScore W2771196527C104317684 @default.
• W2771196527 hasConceptScore W2771196527C126322002 @default.
• W2771196527 hasConceptScore W2771196527C127561419 @default.
• W2771196527 hasConceptScore W2771196527C134018914 @default.
• W2771196527 hasConceptScore W2771196527C160160445 @default.
• W2771196527 hasConceptScore W2771196527C164027704 @default.
• W2771196527 hasConceptScore W2771196527C17991360 @default.
• W2771196527 hasConceptScore W2771196527C181199279 @default.
• W2771196527 hasConceptScore W2771196527C184235292 @default.
• W2771196527 hasConceptScore W2771196527C185592680 @default.
• W2771196527 hasConceptScore W2771196527C2776536020 @default.
• W2771196527 hasConceptScore W2771196527C2776637226 @default.
• W2771196527 hasConceptScore W2771196527C2776877979 @default.
• W2771196527 hasConceptScore W2771196527C2776914184 @default.
• W2771196527 hasConceptScore W2771196527C2777730290 @default.
• W2771196527 hasConceptScore W2771196527C2778754761 @default.
• W2771196527 hasConceptScore W2771196527C2779679107 @default.
• W2771196527 hasConceptScore W2771196527C51551487 @default.
• W2771196527 hasConceptScore W2771196527C55493867 @default.
• W2771196527 hasConceptScore W2771196527C57074206 @default.
• W2771196527 hasConceptScore W2771196527C62478195 @default.
• W2771196527 hasConceptScore W2771196527C71924100 @default.
• W2771196527 hasConceptScore W2771196527C98274493 @default.
• W2771196527 hasFunder F4320322107 @default.
• W2771196527 hasFunder F4320322120 @default.
• W2771196527 hasIssue "7" @default.
• W2771196527 hasLocation W27711965271 @default.

• next