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- W2771249144 abstract "Background: Francis Crick hypothesized certain chemical modifications at the first anticodon nucleotide in each tRNA, because the first anticodon nucleotide interacts with the corresponding third codon nucleotide in mRNA through non-canonical Watson-Crick geometry. We found a modification of taurine at the first anticodon nucleotide in the normal mitochondrial (mt) tRNALeu(UUR). In contrast, the taurine modification is deficient in the mt tRNALeu(UUR) derived from tissues from MELAS patients harboring the A3243G transition. Since the taurine modification defect in the mutant mt tRNA Leu(UUR) causes a deficiency in deciphering codons, we regard MELAS as a first-ever tRNA-modification disorder. Indeed, high-dose taurine supplementation ameliorates impaired mt dysfunction in patient-derived cells and prevents stroke-like episodes in two MELAS patients for more than nine years." @default.
- W2771249144 created "2017-12-22" @default.
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- W2771249144 date "2017-10-01" @default.
- W2771249144 modified "2023-09-25" @default.
- W2771249144 title "Taurine for preventing stroke-like episodes in melas, the first-ever trna modification disorder" @default.
- W2771249144 doi "https://doi.org/10.1016/j.jns.2017.08.489" @default.
- W2771249144 hasPublicationYear "2017" @default.
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