Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771282015> ?p ?o ?g. }
- W2771282015 endingPage "1740" @default.
- W2771282015 startingPage "1726" @default.
- W2771282015 abstract "Background/Aims: In response to traumatic brain injury (TBI), activated microglia exhibit changes in their morphology from the resting ramified phenotype toward the activated hypertrophic or amoeboid phenotype. Here, we provide the first description of the mechanism underlying the neuroprotective effects of γ-secretase inhibitors on TBI outcomes in rats. Methods: The neuroprotective effects of γ-secretase inhibitors such as LY411575 or CHF5074 on TBI-induced neurotoxicity were analysed using a neurological motor function evaluation, cerebral contusion assay, immunohistochemical staining for microglia phenotypes, lung injury score and Evans Blue dye extravasation assay of brain and lung oedema. Results: Hypertrophic or amoeboid microglia accumulated in the injured cortex, the blood-brain-barrier was disrupted and neurological deficits and acute lung injury were observed 4 days after TBI in adult rats. However, a subcutaneous injection of LY411575 (5 mg/kg) or CHF5074 (30 mg/kg) immediately after TBI and once daily for 3 consecutive days post-TBI significantly attenutaed the accumulation of hypertrophic microglia in the injured brain, neurological injury, and neurogenic acute lung injury. Conclusion: Gamma-secretase inhibitors attenuated neurotrauma and neurogenic acute lung injury in rats by reducing the accumulation of hypertrophic microglia in the vicinity of the lesion." @default.
- W2771282015 created "2017-12-22" @default.
- W2771282015 creator A5023625975 @default.
- W2771282015 creator A5025329742 @default.
- W2771282015 creator A5030184709 @default.
- W2771282015 creator A5032571858 @default.
- W2771282015 creator A5050008056 @default.
- W2771282015 creator A5055729433 @default.
- W2771282015 creator A5057241756 @default.
- W2771282015 creator A5083830540 @default.
- W2771282015 date "2017-01-01" @default.
- W2771282015 modified "2023-09-30" @default.
- W2771282015 title "Gamma-Secretase Inhibitors Attenuate Neurotrauma and Neurogenic Acute Lung Injury in Rats by Rescuing the Accumulation of Hypertrophic Microglia" @default.
- W2771282015 cites W1731875419 @default.
- W2771282015 cites W1818428690 @default.
- W2771282015 cites W1911263523 @default.
- W2771282015 cites W1966601014 @default.
- W2771282015 cites W1967859572 @default.
- W2771282015 cites W1983087949 @default.
- W2771282015 cites W1986512401 @default.
- W2771282015 cites W1990819855 @default.
- W2771282015 cites W1991086765 @default.
- W2771282015 cites W199598560 @default.
- W2771282015 cites W2003674452 @default.
- W2771282015 cites W2004872316 @default.
- W2771282015 cites W2013993875 @default.
- W2771282015 cites W2016785381 @default.
- W2771282015 cites W2027046018 @default.
- W2771282015 cites W2031741650 @default.
- W2771282015 cites W2035000249 @default.
- W2771282015 cites W2044990375 @default.
- W2771282015 cites W2049135473 @default.
- W2771282015 cites W2050798507 @default.
- W2771282015 cites W2057600773 @default.
- W2771282015 cites W2063771702 @default.
- W2771282015 cites W2065706231 @default.
- W2771282015 cites W2068049396 @default.
- W2771282015 cites W2079414533 @default.
- W2771282015 cites W2079608251 @default.
- W2771282015 cites W2082836043 @default.
- W2771282015 cites W2084226102 @default.
- W2771282015 cites W2089108509 @default.
- W2771282015 cites W2090406814 @default.
- W2771282015 cites W2092427927 @default.
- W2771282015 cites W2093313949 @default.
- W2771282015 cites W2095157531 @default.
- W2771282015 cites W2097705657 @default.
- W2771282015 cites W2100219429 @default.
- W2771282015 cites W2108435419 @default.
- W2771282015 cites W2117992648 @default.
- W2771282015 cites W2119615201 @default.
- W2771282015 cites W2122828560 @default.
- W2771282015 cites W2123992098 @default.
- W2771282015 cites W2127761382 @default.
- W2771282015 cites W2133929886 @default.
- W2771282015 cites W2135194163 @default.
- W2771282015 cites W2147604161 @default.
- W2771282015 cites W2149058641 @default.
- W2771282015 cites W2149185003 @default.
- W2771282015 cites W2152977980 @default.
- W2771282015 cites W2159816974 @default.
- W2771282015 cites W2164147104 @default.
- W2771282015 cites W2182355171 @default.
- W2771282015 cites W2270628147 @default.
- W2771282015 cites W2403623483 @default.
- W2771282015 cites W2605510493 @default.
- W2771282015 doi "https://doi.org/10.1159/000485778" @default.
- W2771282015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29227981" @default.
- W2771282015 hasPublicationYear "2017" @default.
- W2771282015 type Work @default.
- W2771282015 sameAs 2771282015 @default.
- W2771282015 citedByCount "11" @default.
- W2771282015 countsByYear W27712820152018 @default.
- W2771282015 countsByYear W27712820152019 @default.
- W2771282015 countsByYear W27712820152020 @default.
- W2771282015 countsByYear W27712820152021 @default.
- W2771282015 countsByYear W27712820152022 @default.
- W2771282015 countsByYear W27712820152023 @default.
- W2771282015 crossrefType "journal-article" @default.
- W2771282015 hasAuthorship W2771282015A5023625975 @default.
- W2771282015 hasAuthorship W2771282015A5025329742 @default.
- W2771282015 hasAuthorship W2771282015A5030184709 @default.
- W2771282015 hasAuthorship W2771282015A5032571858 @default.
- W2771282015 hasAuthorship W2771282015A5050008056 @default.
- W2771282015 hasAuthorship W2771282015A5055729433 @default.
- W2771282015 hasAuthorship W2771282015A5057241756 @default.
- W2771282015 hasAuthorship W2771282015A5083830540 @default.
- W2771282015 hasBestOaLocation W27712820151 @default.
- W2771282015 hasConcept C118552586 @default.
- W2771282015 hasConcept C126322002 @default.
- W2771282015 hasConcept C142724271 @default.
- W2771282015 hasConcept C25498285 @default.
- W2771282015 hasConcept C2776914184 @default.
- W2771282015 hasConcept C2777649898 @default.
- W2771282015 hasConcept C2779540182 @default.
- W2771282015 hasConcept C2779830541 @default.
- W2771282015 hasConcept C2781017439 @default.
- W2771282015 hasConcept C42219234 @default.