Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771284881> ?p ?o ?g. }
- W2771284881 endingPage "2613" @default.
- W2771284881 startingPage "2613" @default.
- W2771284881 abstract "O6-DNA-alkyl-guanine-DNA-alkyl-transferases (OGTs) are evolutionarily conserved, unique proteins that repair alkylation lesions in DNA in a single step reaction. Alkylating agents are environmental pollutants as well as by-products of cellular reactions, but are also very effective chemotherapeutic drugs. OGTs are major players in counteracting the effects of such agents, thus their action in turn affects genome integrity, survival of organisms under challenging conditions and response to chemotherapy. Numerous studies on OGTs from eukaryotes, bacteria and archaea have been reported, highlighting amazing features that make OGTs unique proteins in their reaction mechanism as well as post-reaction fate. This review reports recent functional and structural data on two prokaryotic OGTs, from the pathogenic bacterium Mycobacterium tuberculosis and the hyperthermophilic archaeon Sulfolobus solfataricus, respectively. These studies provided insight in the role of OGTs in the biology of these microorganisms, but also important hints useful to understand the general properties of this class of proteins." @default.
- W2771284881 created "2017-12-22" @default.
- W2771284881 creator A5017132282 @default.
- W2771284881 creator A5045705816 @default.
- W2771284881 creator A5056854971 @default.
- W2771284881 creator A5075869335 @default.
- W2771284881 creator A5086305931 @default.
- W2771284881 creator A5090108269 @default.
- W2771284881 date "2017-12-05" @default.
- W2771284881 modified "2023-10-16" @default.
- W2771284881 title "Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights" @default.
- W2771284881 cites W1550292471 @default.
- W2771284881 cites W1859592247 @default.
- W2771284881 cites W1948660767 @default.
- W2771284881 cites W1964082387 @default.
- W2771284881 cites W1970270735 @default.
- W2771284881 cites W1971416198 @default.
- W2771284881 cites W1971453694 @default.
- W2771284881 cites W1979392838 @default.
- W2771284881 cites W1982720579 @default.
- W2771284881 cites W1986004462 @default.
- W2771284881 cites W1987038511 @default.
- W2771284881 cites W1988406719 @default.
- W2771284881 cites W1989499442 @default.
- W2771284881 cites W1993931802 @default.
- W2771284881 cites W1994782502 @default.
- W2771284881 cites W1996338823 @default.
- W2771284881 cites W1999549596 @default.
- W2771284881 cites W2004361822 @default.
- W2771284881 cites W2007097682 @default.
- W2771284881 cites W2008204275 @default.
- W2771284881 cites W2008466187 @default.
- W2771284881 cites W2008826386 @default.
- W2771284881 cites W2016036293 @default.
- W2771284881 cites W2019243649 @default.
- W2771284881 cites W2020654558 @default.
- W2771284881 cites W2025515800 @default.
- W2771284881 cites W2025605138 @default.
- W2771284881 cites W2032579724 @default.
- W2771284881 cites W2033386962 @default.
- W2771284881 cites W2039067592 @default.
- W2771284881 cites W2049163206 @default.
- W2771284881 cites W2049881962 @default.
- W2771284881 cites W2050776447 @default.
- W2771284881 cites W2051416237 @default.
- W2771284881 cites W2052118895 @default.
- W2771284881 cites W2055381727 @default.
- W2771284881 cites W2056771672 @default.
- W2771284881 cites W2057141116 @default.
- W2771284881 cites W2062275612 @default.
- W2771284881 cites W2071310636 @default.
- W2771284881 cites W2071616360 @default.
- W2771284881 cites W2074977677 @default.
- W2771284881 cites W2076557946 @default.
- W2771284881 cites W2094344570 @default.
- W2771284881 cites W2094763329 @default.
- W2771284881 cites W2096136751 @default.
- W2771284881 cites W2098672022 @default.
- W2771284881 cites W2111689950 @default.
- W2771284881 cites W2112461694 @default.
- W2771284881 cites W2120560672 @default.
- W2771284881 cites W2127068865 @default.
- W2771284881 cites W2128482141 @default.
- W2771284881 cites W2134090171 @default.
- W2771284881 cites W2135993278 @default.
- W2771284881 cites W2136698121 @default.
- W2771284881 cites W2142427369 @default.
- W2771284881 cites W2143983454 @default.
- W2771284881 cites W2145498720 @default.
- W2771284881 cites W2147696493 @default.
- W2771284881 cites W2158708098 @default.
- W2771284881 cites W2160204148 @default.
- W2771284881 cites W2160338675 @default.
- W2771284881 cites W2164390042 @default.
- W2771284881 cites W2164784743 @default.
- W2771284881 cites W2167447947 @default.
- W2771284881 cites W2168455096 @default.
- W2771284881 cites W2170427174 @default.
- W2771284881 cites W2171935374 @default.
- W2771284881 cites W2175536752 @default.
- W2771284881 cites W2330272288 @default.
- W2771284881 cites W2536231796 @default.
- W2771284881 cites W2548294337 @default.
- W2771284881 cites W2620391055 @default.
- W2771284881 cites W2762891710 @default.
- W2771284881 cites W2763513988 @default.
- W2771284881 cites W3126046906 @default.
- W2771284881 cites W4245071093 @default.
- W2771284881 cites W1988728408 @default.
- W2771284881 doi "https://doi.org/10.3390/ijms18122613" @default.
- W2771284881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5751216" @default.
- W2771284881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29206193" @default.
- W2771284881 hasPublicationYear "2017" @default.
- W2771284881 type Work @default.
- W2771284881 sameAs 2771284881 @default.
- W2771284881 citedByCount "14" @default.
- W2771284881 countsByYear W27712848812018 @default.
- W2771284881 countsByYear W27712848812019 @default.