Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771292248> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2771292248 abstract "We demonstrated that targeted-gold-nanoparticles loaded with everolimus (GNP-HCe) were effective in vitro inhibiting mesenchymal cells isolated from bronchoalveolar lavage of BOS patients. Here, we investigated the effect of GNPs on inflammatory cells, given that a stimulating effect is strongly unwanted. Macrophages were obtained from BAL by adhesion procedure, lymphocytes and neutrophils from peripheral blood by Lympholyte. Cells were incubated with GNP-HC (targeted GNP without everolimus), GNP-HCe, everolimus (EV) and medium. IL-8 was assayed by ELISA, IFN-g, IL-17 and IL-10 by Elispot. Elastase release was evaluated by enzymatic test. Apoptosis, CD3+CD4+, CD3+CD8+ populations and CCR7 expression were analyzed by flow cytometry, cell viability by MTT test, and mitochondria membrane potential by JC-1 fluorescence. Reactive oxygen species (ROS) production was assayed by EPR spectroscopy. GNP-HCe did not stimulate IL-8 secretion by macrophages but reduced cell viability (p Our study confirm that GNP-HCe are able to exert its therapeutic action without activating immune effectors with positive implications on the translational potential of this therapeutic strategy." @default.
- W2771292248 created "2017-12-22" @default.
- W2771292248 creator A5011206324 @default.
- W2771292248 creator A5023361737 @default.
- W2771292248 creator A5028842822 @default.
- W2771292248 creator A5034685500 @default.
- W2771292248 creator A5042690458 @default.
- W2771292248 creator A5058094535 @default.
- W2771292248 creator A5059444134 @default.
- W2771292248 creator A5063275337 @default.
- W2771292248 creator A5086466650 @default.
- W2771292248 creator A5088354570 @default.
- W2771292248 creator A5088698720 @default.
- W2771292248 date "2017-09-01" @default.
- W2771292248 modified "2023-10-15" @default.
- W2771292248 title "Bioengineered nanoparticles targeted to mesenchymal cells from patients with BOS exert anti-inflammatory activity" @default.
- W2771292248 doi "https://doi.org/10.1183/1393003.congress-2017.oa1994" @default.
- W2771292248 hasPublicationYear "2017" @default.
- W2771292248 type Work @default.
- W2771292248 sameAs 2771292248 @default.
- W2771292248 citedByCount "0" @default.
- W2771292248 crossrefType "proceedings-article" @default.
- W2771292248 hasAuthorship W2771292248A5011206324 @default.
- W2771292248 hasAuthorship W2771292248A5023361737 @default.
- W2771292248 hasAuthorship W2771292248A5028842822 @default.
- W2771292248 hasAuthorship W2771292248A5034685500 @default.
- W2771292248 hasAuthorship W2771292248A5042690458 @default.
- W2771292248 hasAuthorship W2771292248A5058094535 @default.
- W2771292248 hasAuthorship W2771292248A5059444134 @default.
- W2771292248 hasAuthorship W2771292248A5063275337 @default.
- W2771292248 hasAuthorship W2771292248A5086466650 @default.
- W2771292248 hasAuthorship W2771292248A5088354570 @default.
- W2771292248 hasAuthorship W2771292248A5088698720 @default.
- W2771292248 hasConcept C142724271 @default.
- W2771292248 hasConcept C153911025 @default.
- W2771292248 hasConcept C167672396 @default.
- W2771292248 hasConcept C190283241 @default.
- W2771292248 hasConcept C198826908 @default.
- W2771292248 hasConcept C203014093 @default.
- W2771292248 hasConcept C2779053233 @default.
- W2771292248 hasConcept C502942594 @default.
- W2771292248 hasConcept C53227056 @default.
- W2771292248 hasConcept C553184892 @default.
- W2771292248 hasConcept C55493867 @default.
- W2771292248 hasConcept C71924100 @default.
- W2771292248 hasConcept C86803240 @default.
- W2771292248 hasConcept C8891405 @default.
- W2771292248 hasConceptScore W2771292248C142724271 @default.
- W2771292248 hasConceptScore W2771292248C153911025 @default.
- W2771292248 hasConceptScore W2771292248C167672396 @default.
- W2771292248 hasConceptScore W2771292248C190283241 @default.
- W2771292248 hasConceptScore W2771292248C198826908 @default.
- W2771292248 hasConceptScore W2771292248C203014093 @default.
- W2771292248 hasConceptScore W2771292248C2779053233 @default.
- W2771292248 hasConceptScore W2771292248C502942594 @default.
- W2771292248 hasConceptScore W2771292248C53227056 @default.
- W2771292248 hasConceptScore W2771292248C553184892 @default.
- W2771292248 hasConceptScore W2771292248C55493867 @default.
- W2771292248 hasConceptScore W2771292248C71924100 @default.
- W2771292248 hasConceptScore W2771292248C86803240 @default.
- W2771292248 hasConceptScore W2771292248C8891405 @default.
- W2771292248 hasLocation W27712922481 @default.
- W2771292248 hasOpenAccess W2771292248 @default.
- W2771292248 hasPrimaryLocation W27712922481 @default.
- W2771292248 hasRelatedWork W1547431047 @default.
- W2771292248 hasRelatedWork W1971564609 @default.
- W2771292248 hasRelatedWork W2052321590 @default.
- W2771292248 hasRelatedWork W2074909052 @default.
- W2771292248 hasRelatedWork W2122827153 @default.
- W2771292248 hasRelatedWork W2350792890 @default.
- W2771292248 hasRelatedWork W2358788014 @default.
- W2771292248 hasRelatedWork W2415912501 @default.
- W2771292248 hasRelatedWork W2419594630 @default.
- W2771292248 hasRelatedWork W2442418843 @default.
- W2771292248 hasRelatedWork W2517304136 @default.
- W2771292248 hasRelatedWork W2809762869 @default.
- W2771292248 hasRelatedWork W2888332148 @default.
- W2771292248 hasRelatedWork W2969477092 @default.
- W2771292248 hasRelatedWork W2973091526 @default.
- W2771292248 hasRelatedWork W2983388234 @default.
- W2771292248 hasRelatedWork W3032235562 @default.
- W2771292248 hasRelatedWork W3128516147 @default.
- W2771292248 hasRelatedWork W3173858527 @default.
- W2771292248 hasRelatedWork W2181345535 @default.
- W2771292248 isParatext "false" @default.
- W2771292248 isRetracted "false" @default.
- W2771292248 magId "2771292248" @default.
- W2771292248 workType "article" @default.