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• W2771365455 abstract "Precision medicine has a goal of customizing disease prevention and treatment strategies. Under the precision medicine paradigm, each patient has unique pathologic processes resulting from cellular genomic, epigenomic, proteomic, and metabolomic alterations, which are influenced by pharmacological, environmental, microbial, dietary, and lifestyle factors. Hence, to realize the promise of precision medicine, multi-level research methods that can comprehensively analyze many of these variables are needed. In order to address this gap, the integrative field of molecular pathology and population data science (i.e., molecular pathological epidemiology) has been developed to enable such multi-level analyses, especially in gastrointestinal cancer research. Further integration of pharmacology can improve our understanding of drug effects, and inform decision-making of drug use at both the individual and population levels. Such integrative research demonstrated potential benefits of aspirin in colorectal carcinoma with PIK3CA mutations, providing the basis for new clinical trials. Evidence also suggests that HPGD (15-PDGH) expression levels in normal colon and the germline rs6983267 polymorphism that relates to tumor CTNNB1 (β-catenin)/WNT signaling status may predict the efficacy of aspirin for cancer chemoprevention. As immune checkpoint blockade targeting the CD274 (PD-L1)/PDCD1 (PD-1) pathway for microsatellite instability-high (or mismatch repair-deficient) metastatic gastrointestinal or other tumors has become standard of care, potential modifying effects of dietary, lifestyle, microbial, and environmental factors on immunotherapy need to be studied to further optimize treatment strategies. With its broad applicability, our integrative approach can provide insights into the interactive role of medications, exposures, and molecular pathology, and guide the development of precision medicine." @default.
• W2771365455 created "2017-12-22" @default.
• W2771365455 creator A5024395036 @default.
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• W2771365455 creator A5085236177 @default.
• W2771365455 date "2017-12-06" @default.
• W2771365455 modified "2023-10-12" @default.
• W2771365455 title "Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology" @default.
• W2771365455 cites W1537445952 @default.
• W2771365455 cites W1576424227 @default.
• W2771365455 cites W1859257957 @default.
• W2771365455 cites W1877133440 @default.
• W2771365455 cites W1900950561 @default.
• W2771365455 cites W1947010865 @default.
• W2771365455 cites W1965631677 @default.
• W2771365455 cites W1968687302 @default.
• W2771365455 cites W1973076801 @default.
• W2771365455 cites W1981548531 @default.
• W2771365455 cites W1987648433 @default.
• W2771365455 cites W1990078462 @default.
• W2771365455 cites W1999571408 @default.
• W2771365455 cites W2008514216 @default.
• W2771365455 cites W2011995257 @default.
• W2771365455 cites W2024830921 @default.
• W2771365455 cites W2031205815 @default.
• W2771365455 cites W2037952228 @default.
• W2771365455 cites W2046458419 @default.
• W2771365455 cites W2047131872 @default.
• W2771365455 cites W2055176101 @default.
• W2771365455 cites W2056632907 @default.
• W2771365455 cites W2058646321 @default.
• W2771365455 cites W2060427373 @default.
• W2771365455 cites W2065460422 @default.
• W2771365455 cites W2068978328 @default.
• W2771365455 cites W2069443403 @default.
• W2771365455 cites W2071441216 @default.
• W2771365455 cites W2077181076 @default.
• W2771365455 cites W2082035590 @default.
• W2771365455 cites W2089834984 @default.
• W2771365455 cites W2093550207 @default.
• W2771365455 cites W2096849313 @default.
• W2771365455 cites W2099556709 @default.
• W2771365455 cites W2101198015 @default.
• W2771365455 cites W2107436924 @default.
• W2771365455 cites W2108614108 @default.
• W2771365455 cites W2112521802 @default.
• W2771365455 cites W2115695399 @default.
• W2771365455 cites W2125241873 @default.
• W2771365455 cites W2131371081 @default.
• W2771365455 cites W2133984007 @default.
• W2771365455 cites W2134724739 @default.
• W2771365455 cites W2135158008 @default.
• W2771365455 cites W2141484415 @default.
• W2771365455 cites W2142783873 @default.
• W2771365455 cites W2144496040 @default.
• W2771365455 cites W2144981148 @default.
• W2771365455 cites W2146894502 @default.
• W2771365455 cites W2151606046 @default.
• W2771365455 cites W2152196433 @default.
• W2771365455 cites W2157341902 @default.
• W2771365455 cites W2159187753 @default.
• W2771365455 cites W2161483608 @default.
• W2771365455 cites W2163072775 @default.
• W2771365455 cites W2174994807 @default.
• W2771365455 cites W2176184837 @default.
• W2771365455 cites W2179203417 @default.
• W2771365455 cites W2183695321 @default.
• W2771365455 cites W2187378598 @default.
• W2771365455 cites W2206536107 @default.
• W2771365455 cites W2216190696 @default.
• W2771365455 cites W2224030228 @default.
• W2771365455 cites W2244314249 @default.
• W2771365455 cites W2251113869 @default.
• W2771365455 cites W2261067062 @default.
• W2771365455 cites W2262329766 @default.
• W2771365455 cites W2285237921 @default.
• W2771365455 cites W2290813370 @default.
• W2771365455 cites W2291499494 @default.
• W2771365455 cites W2294346158 @default.
• W2771365455 cites W2299919100 @default.
• W2771365455 cites W2391651292 @default.
• W2771365455 cites W240667900 @default.
• W2771365455 cites W2413444331 @default.
• W2771365455 cites W2418794140 @default.
• W2771365455 cites W2465739951 @default.
• W2771365455 cites W2476051373 @default.
• W2771365455 cites W2512558866 @default.
• W2771365455 cites W2516924313 @default.
• W2771365455 cites W2518407064 @default.
• W2771365455 cites W2524674731 @default.
• W2771365455 cites W2530952499 @default.

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