Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771447551> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2771447551 endingPage "410" @default.
- W2771447551 startingPage "402" @default.
- W2771447551 abstract "Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6’)-Im – Aminoglycoside 6’-acetyltransferase-Im (AAC(6’)-Im) is the closest monofunctional homolog of the AAC(6’)-Ie acetyltransferase of the bifunctional enzyme AAC(6’)-Ie/APH(2”)-Ia. The AAC(6’)-Im acetyltransferase confers 4- to 64-fold higher MICs to 4,6-disubstituted aminoglycosides and the 4,5-disubstituted aminoglycoside neomycin than AAC(6’)-Ie, yet unlike AAC(6’)-Ie, the AAC(6’)-Im enzyme does not confer resistance to the atypical aminoglycoside fortimicin. The structure of the kanamycin A complex of AAC(6’)-Im shows that the substrate binds in a shallow positively-charged pocket, with the N6’ amino group positioned appropriately for an efficient nucleophilic attack on an acetyl-CoA cofactor. The AAC(6’)-Ie enzyme binds kanamycin A in a sufficiently (...)" @default.
- W2771447551 created "2017-12-22" @default.
- W2771447551 creator A5015020592 @default.
- W2771447551 creator A5018188998 @default.
- W2771447551 creator A5025508453 @default.
- W2771447551 creator A5043351423 @default.
- W2771447551 creator A5055520214 @default.
- W2771447551 date "2017-12-04" @default.
- W2771447551 modified "2023-10-17" @default.
- W2771447551 title "Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6’)-Im" @default.
- W2771447551 cites W1533496027 @default.
- W2771447551 cites W1540826264 @default.
- W2771447551 cites W1960965614 @default.
- W2771447551 cites W1983946633 @default.
- W2771447551 cites W1986837481 @default.
- W2771447551 cites W1995143758 @default.
- W2771447551 cites W2025851772 @default.
- W2771447551 cites W2035788433 @default.
- W2771447551 cites W2046513994 @default.
- W2771447551 cites W2046757176 @default.
- W2771447551 cites W2048982435 @default.
- W2771447551 cites W2052328192 @default.
- W2771447551 cites W2080731412 @default.
- W2771447551 cites W2085162369 @default.
- W2771447551 cites W2086223988 @default.
- W2771447551 cites W2110424949 @default.
- W2771447551 cites W2110808180 @default.
- W2771447551 cites W2114204264 @default.
- W2771447551 cites W2114622716 @default.
- W2771447551 cites W2121875360 @default.
- W2771447551 cites W2127653962 @default.
- W2771447551 cites W2133028512 @default.
- W2771447551 cites W2147874841 @default.
- W2771447551 cites W2151730195 @default.
- W2771447551 cites W2164448039 @default.
- W2771447551 cites W2168870245 @default.
- W2771447551 cites W2170243611 @default.
- W2771447551 cites W2545925691 @default.
- W2771447551 doi "https://doi.org/10.15698/mic2017.12.602" @default.
- W2771447551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5722643" @default.
- W2771447551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29234669" @default.
- W2771447551 hasPublicationYear "2017" @default.
- W2771447551 type Work @default.
- W2771447551 sameAs 2771447551 @default.
- W2771447551 citedByCount "10" @default.
- W2771447551 countsByYear W27714475512019 @default.
- W2771447551 countsByYear W27714475512021 @default.
- W2771447551 countsByYear W27714475512022 @default.
- W2771447551 countsByYear W27714475512023 @default.
- W2771447551 crossrefType "journal-article" @default.
- W2771447551 hasAuthorship W2771447551A5015020592 @default.
- W2771447551 hasAuthorship W2771447551A5018188998 @default.
- W2771447551 hasAuthorship W2771447551A5025508453 @default.
- W2771447551 hasAuthorship W2771447551A5043351423 @default.
- W2771447551 hasAuthorship W2771447551A5055520214 @default.
- W2771447551 hasBestOaLocation W27714475511 @default.
- W2771447551 hasConcept C104317684 @default.
- W2771447551 hasConcept C119157956 @default.
- W2771447551 hasConcept C185592680 @default.
- W2771447551 hasConcept C2777787772 @default.
- W2771447551 hasConcept C2779649592 @default.
- W2771447551 hasConcept C2779841869 @default.
- W2771447551 hasConcept C2780920689 @default.
- W2771447551 hasConcept C501593827 @default.
- W2771447551 hasConcept C55493867 @default.
- W2771447551 hasConceptScore W2771447551C104317684 @default.
- W2771447551 hasConceptScore W2771447551C119157956 @default.
- W2771447551 hasConceptScore W2771447551C185592680 @default.
- W2771447551 hasConceptScore W2771447551C2777787772 @default.
- W2771447551 hasConceptScore W2771447551C2779649592 @default.
- W2771447551 hasConceptScore W2771447551C2779841869 @default.
- W2771447551 hasConceptScore W2771447551C2780920689 @default.
- W2771447551 hasConceptScore W2771447551C501593827 @default.
- W2771447551 hasConceptScore W2771447551C55493867 @default.
- W2771447551 hasIssue "12" @default.
- W2771447551 hasLocation W27714475511 @default.
- W2771447551 hasLocation W27714475512 @default.
- W2771447551 hasLocation W27714475513 @default.
- W2771447551 hasLocation W27714475514 @default.
- W2771447551 hasOpenAccess W2771447551 @default.
- W2771447551 hasPrimaryLocation W27714475511 @default.
- W2771447551 hasRelatedWork W1977984224 @default.
- W2771447551 hasRelatedWork W2053778219 @default.
- W2771447551 hasRelatedWork W2135459061 @default.
- W2771447551 hasRelatedWork W2149663262 @default.
- W2771447551 hasRelatedWork W2185501082 @default.
- W2771447551 hasRelatedWork W2317331361 @default.
- W2771447551 hasRelatedWork W2897856949 @default.
- W2771447551 hasRelatedWork W2949791792 @default.
- W2771447551 hasRelatedWork W2950553847 @default.
- W2771447551 hasRelatedWork W4243559997 @default.
- W2771447551 hasVolume "4" @default.
- W2771447551 isParatext "false" @default.
- W2771447551 isRetracted "false" @default.
- W2771447551 magId "2771447551" @default.
- W2771447551 workType "article" @default.