Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771485688> ?p ?o ?g. }
- W2771485688 endingPage "48" @default.
- W2771485688 startingPage "30" @default.
- W2771485688 abstract "CD8+ T cells are central players in controlling infections and cancer. Longevity, functionality, and metabolic fitness are critical determinants of T cell efficacy in cancer immunotherapy. Tumor-infiltrating CD8+ T cells undergo metabolic 'exhaustion' in the nutrient- and oxygen-deprived tumor microenvironment (TME). Thus, reprograming CD8+ T cell metabolism may provide important therapeutic strategies for cancer treatment. Indeed, the adoptive transfer of memory CD8+ T cells with sustained metabolic fitness may yield better antitumor protection in both mouse models and the clinic. Here, we discuss recent progress on how cellular metabolism is linked to CD8+ T cell fate decisions and on how metabolic intermediates can impact gene expression via modulation of the epigenome. We examine the feasibility of developing potential strategies to improve antitumor immunity through the modulation of T cell metabolic activity." @default.
- W2771485688 created "2017-12-22" @default.
- W2771485688 creator A5004102058 @default.
- W2771485688 creator A5071971878 @default.
- W2771485688 date "2018-01-01" @default.
- W2771485688 modified "2023-10-18" @default.
- W2771485688 title "Metabolic Control of CD8+ T Cell Fate Decisions and Antitumor Immunity" @default.
- W2771485688 cites W1006554241 @default.
- W2771485688 cites W1498931318 @default.
- W2771485688 cites W1563775926 @default.
- W2771485688 cites W1568778024 @default.
- W2771485688 cites W1627187635 @default.
- W2771485688 cites W1781304070 @default.
- W2771485688 cites W1882193637 @default.
- W2771485688 cites W1964081728 @default.
- W2771485688 cites W1967727543 @default.
- W2771485688 cites W1970041220 @default.
- W2771485688 cites W1973601490 @default.
- W2771485688 cites W1975783419 @default.
- W2771485688 cites W1976714959 @default.
- W2771485688 cites W1980760876 @default.
- W2771485688 cites W1982704558 @default.
- W2771485688 cites W1992250154 @default.
- W2771485688 cites W1992962914 @default.
- W2771485688 cites W1993023349 @default.
- W2771485688 cites W1993686673 @default.
- W2771485688 cites W1999324987 @default.
- W2771485688 cites W2000725338 @default.
- W2771485688 cites W2003398132 @default.
- W2771485688 cites W2004629226 @default.
- W2771485688 cites W2020604513 @default.
- W2771485688 cites W2025714915 @default.
- W2771485688 cites W2030375564 @default.
- W2771485688 cites W2042699075 @default.
- W2771485688 cites W2043904711 @default.
- W2771485688 cites W2044104392 @default.
- W2771485688 cites W2049042780 @default.
- W2771485688 cites W2061318708 @default.
- W2771485688 cites W2063888187 @default.
- W2771485688 cites W2064876347 @default.
- W2771485688 cites W2065779229 @default.
- W2771485688 cites W2075901463 @default.
- W2771485688 cites W2079999658 @default.
- W2771485688 cites W2080196128 @default.
- W2771485688 cites W2084317828 @default.
- W2771485688 cites W2084561923 @default.
- W2771485688 cites W2096270448 @default.
- W2771485688 cites W2097821680 @default.
- W2771485688 cites W2100039832 @default.
- W2771485688 cites W2102411973 @default.
- W2771485688 cites W2104156406 @default.
- W2771485688 cites W2113052538 @default.
- W2771485688 cites W2116676186 @default.
- W2771485688 cites W2117931978 @default.
- W2771485688 cites W2130746744 @default.
- W2771485688 cites W2132667524 @default.
- W2771485688 cites W2134892089 @default.
- W2771485688 cites W2141730355 @default.
- W2771485688 cites W2144796561 @default.
- W2771485688 cites W2145026575 @default.
- W2771485688 cites W2146791037 @default.
- W2771485688 cites W2149099076 @default.
- W2771485688 cites W2160551785 @default.
- W2771485688 cites W2164796013 @default.
- W2771485688 cites W2167432954 @default.
- W2771485688 cites W2182743085 @default.
- W2771485688 cites W2202401513 @default.
- W2771485688 cites W2206617731 @default.
- W2771485688 cites W2252585899 @default.
- W2771485688 cites W2259021796 @default.
- W2771485688 cites W2273004055 @default.
- W2771485688 cites W2285239684 @default.
- W2771485688 cites W2299840252 @default.
- W2771485688 cites W2302941161 @default.
- W2771485688 cites W2319053438 @default.
- W2771485688 cites W2321920454 @default.
- W2771485688 cites W2401038200 @default.
- W2771485688 cites W2401536218 @default.
- W2771485688 cites W2406612864 @default.
- W2771485688 cites W2415427537 @default.
- W2771485688 cites W2468925656 @default.
- W2771485688 cites W2472560175 @default.
- W2771485688 cites W2478467838 @default.
- W2771485688 cites W2503407514 @default.
- W2771485688 cites W2507334943 @default.
- W2771485688 cites W2510836433 @default.
- W2771485688 cites W2519020116 @default.
- W2771485688 cites W2519107733 @default.
- W2771485688 cites W2523989131 @default.
- W2771485688 cites W2530067632 @default.
- W2771485688 cites W2537440061 @default.
- W2771485688 cites W2545009331 @default.
- W2771485688 cites W2554003937 @default.
- W2771485688 cites W2562213801 @default.
- W2771485688 cites W2587691649 @default.
- W2771485688 cites W2589066097 @default.
- W2771485688 cites W2606693187 @default.
- W2771485688 cites W2616155686 @default.