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- W2771512942 abstract "Background: Living donor liver transplantation (LDLT) can provide life-saving therapy for many patients with hepatocellular carcinoma (HCC). Ultrasound (US), Multislice computed tomography (CT) and Positron emission tomography (PET) are used for pretransplant HCC evaluation. Objective: The objective of this study was to determine the accuracy of different imaging modalities in assessment of HCC patients for LDLT, in correlation with the histopathological study of the explanted liver. Also, to study the effectiveness of these imaging modalities to classify the potential recipients as regard the different selection criteria, and to assess their feasibility in evaluation of the effectiveness of pretransplant bridging procedures. Methods: From April 2003 to December 2013, 61 of 210 recipients underwent LDLT for HCC at National Liver Institute, Menofia University, Egypt. Imaging findings were correlated with histopathologic features of the explanted livers. Results: Sixty one patients of 210 underwent LDLT for HCC, 54 patients of them proved to be HCC in pathology of explanted liver. Sensitivity & specificity of US & CT scan for detection of HCC were (100%) and (95.5%) respectively. Sensitivity & specificity of PET scan were (44.8%), (50%) respectively. US overestimated numbers and sizes of HCCs by 13/54 (24.1%) and 14/54 (25.9%) respectively. CT overestimated numbers & sizes of HCCs by 14/54 (25.9%), and 12/54 (22.2%) respectively. Thirty nine (63.9%) patients were within imaging Milan, and 51(83.6%) patients were within imaging University of California, San Francisco (UCSF) criteria, but 35(64.8%) patients were within pathological Milan, and 40(74.1%) patients were within pathological UCSF criteria. Nineteen (35.2%) patients underwent pretransplant bridging therapy for HCC, and only 3 patients had complete ablation in pathology of explanted liver. Conclusion: US & CT scan have high sensitivity for detection of HCC, and PET scan has less sensitivity, but PET scan might be of particular value in excluding extrahepatic HCC extension. Fallacies of the imaging study due to overestimation and underestimation should be considered during scheduling according to selection criteria. CT has doubtful value in addressing the efficacy of bridging therapy for HCC." @default.
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- W2771512942 date "2014-07-01" @default.
- W2771512942 modified "2023-09-26" @default.
- W2771512942 title "Accuracy of Imaging Study in Correlation to Pathology of Explanted Liver of Hepatocellular Carcinoma Cases." @default.
- W2771512942 doi "https://doi.org/10.1097/00007890-201407151-02690" @default.
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