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- W2771569102 abstract "Aspartate β-semialdehyde dehydrogenase (ASADH) is an enzyme involved in the diaminopimelate pathway of lysine biosynthesis. It is essential for the viability of many pathogenic bacteria and therefore has been the subject of considerable research for the generation of novel antibiotic compounds. This manuscript describes the first structure of ASADH from Francisella tularensis, the causative agent of tularemia and a potential bioterrorism agent. The structure was determined at 2.45 Å resolution and has a similar biological assembly to other bacterial homologs. ASADH is known to be dimeric in bacteria and have extensive interchain contacts, which are thought to create a half-sites reactivity enzyme. ASADH from higher organisms shows a tetrameric oligomerization, which also has implications for both reactivity and regulation. This work analyzes the apo form of F. tularensis ASADH, as well as the binding of the enzyme to its cofactor NADP+." @default.
- W2771569102 created "2017-12-22" @default.
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- W2771569102 date "2018-01-01" @default.
- W2771569102 modified "2023-10-15" @default.
- W2771569102 title "Structure of aspartate β-semialdehyde dehydrogenase from<i>Francisella tularensis</i>" @default.
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- W2771569102 doi "https://doi.org/10.1107/s2053230x17017241" @default.
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