FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771770396> ?p ?o ?g. }

• W2771770396 abstract "The healthy human body contains small amounts of metabolic formaldehyde (FA) that mainly results from methanol oxidation by pectin methylesterase, which is active in a vegetable diet and in the gastrointestinal microbiome. With age, the ability to maintain a low level of FA decreases, which increases the risk of Alzheimer's disease and dementia. It has been shown that 1,2-dithiolane-3-pentanoic acid or alpha lipoic acid (ALA), a naturally occurring dithiol and antioxidant cofactor of mitochondrial α-ketoacid dehydrogenases, increases glutathione (GSH) content and FA metabolism by mitochondrial aldehyde dehydrogenase 2 (ALDH2) thus manifests a therapeutic potential beyond its antioxidant property. We suggested that ALA can contribute to a decrease in the FA content of mammals by acting on ALDH2 expression. To test this assumption, we administered ALA in mice in order to examine the effect on FA metabolism and collected blood samples for the measurement of FA. Our data revealed that ALA efficiently eliminated FA in mice. Without affecting the specific activity of FA-metabolizing enzymes (ADH1, ALDH2, and ADH5), ALA increased the GSH content in the brain and up-regulated the expression of the FA-metabolizing ALDH2 gene in the brain, particularly in the hippocampus, but did not impact its expression in the liver in vivo or in rat liver isolated from the rest of the body. After ALA administration in mice and in accordance with the increased content of brain ALDH2 mRNA, we detected increased ALDH2 activity in brain homogenates. We hypothesized that the beneficial effects of ALA on patients with Alzheimer's disease may be associated with accelerated ALDH2-mediated FA detoxification and clearance." @default.
• W2771770396 created "2017-12-22" @default.
• W2771770396 creator A5012209856 @default.
• W2771770396 creator A5034581966 @default.
• W2771770396 creator A5037469632 @default.
• W2771770396 creator A5042139935 @default.
• W2771770396 creator A5042561890 @default.
• W2771770396 creator A5051492903 @default.
• W2771770396 creator A5055235871 @default.
• W2771770396 creator A5063639723 @default.
• W2771770396 creator A5066173922 @default.
• W2771770396 creator A5089026592 @default.
• W2771770396 date "2017-12-01" @default.
• W2771770396 modified "2023-10-04" @default.
• W2771770396 title "The Antioxidant Cofactor Alpha-Lipoic Acid May Control Endogenous Formaldehyde Metabolism in Mammals" @default.
• W2771770396 cites W1497645148 @default.
• W2771770396 cites W1537399669 @default.
• W2771770396 cites W1560978813 @default.
• W2771770396 cites W1839777185 @default.
• W2771770396 cites W1964455811 @default.
• W2771770396 cites W1965171677 @default.
• W2771770396 cites W1965696818 @default.
• W2771770396 cites W1971285171 @default.
• W2771770396 cites W1971722312 @default.
• W2771770396 cites W1978585143 @default.
• W2771770396 cites W1983325133 @default.
• W2771770396 cites W1994471840 @default.
• W2771770396 cites W1995484163 @default.
• W2771770396 cites W1995630908 @default.
• W2771770396 cites W1996485249 @default.
• W2771770396 cites W1997254225 @default.
• W2771770396 cites W2001986473 @default.
• W2771770396 cites W2003379970 @default.
• W2771770396 cites W2005651592 @default.
• W2771770396 cites W2007321017 @default.
• W2771770396 cites W2007394501 @default.
• W2771770396 cites W2025458587 @default.
• W2771770396 cites W2025657346 @default.
• W2771770396 cites W2028370709 @default.
• W2771770396 cites W2029309347 @default.
• W2771770396 cites W2035267505 @default.
• W2771770396 cites W2045155139 @default.
• W2771770396 cites W2048099798 @default.
• W2771770396 cites W2053814042 @default.
• W2771770396 cites W2054643318 @default.
• W2771770396 cites W2057099146 @default.
• W2771770396 cites W2067794214 @default.
• W2771770396 cites W2069110711 @default.
• W2771770396 cites W2070493228 @default.
• W2771770396 cites W2072260387 @default.
• W2771770396 cites W2073548086 @default.
• W2771770396 cites W2075268562 @default.
• W2771770396 cites W2077844777 @default.
• W2771770396 cites W2081776102 @default.
• W2771770396 cites W2082329237 @default.
• W2771770396 cites W2083165373 @default.
• W2771770396 cites W2084404868 @default.
• W2771770396 cites W2087763476 @default.
• W2771770396 cites W2092271268 @default.
• W2771770396 cites W2093581304 @default.
• W2771770396 cites W2095443848 @default.
• W2771770396 cites W2102304447 @default.
• W2771770396 cites W2103377484 @default.
• W2771770396 cites W2108244474 @default.
• W2771770396 cites W2110292185 @default.
• W2771770396 cites W2114037027 @default.
• W2771770396 cites W2116467413 @default.
• W2771770396 cites W2117446864 @default.
• W2771770396 cites W2123552387 @default.
• W2771770396 cites W2123665978 @default.
• W2771770396 cites W2125863862 @default.
• W2771770396 cites W2133612797 @default.
• W2771770396 cites W2136783171 @default.
• W2771770396 cites W2142760586 @default.
• W2771770396 cites W2146627313 @default.
• W2771770396 cites W2149374543 @default.
• W2771770396 cites W2149695479 @default.
• W2771770396 cites W2156813826 @default.
• W2771770396 cites W2161190905 @default.
• W2771770396 cites W2161529514 @default.
• W2771770396 cites W2286050125 @default.
• W2771770396 cites W2294631298 @default.
• W2771770396 cites W2300761166 @default.
• W2771770396 cites W2337732629 @default.
• W2771770396 cites W2409411040 @default.
• W2771770396 cites W2527779110 @default.
• W2771770396 cites W2527937058 @default.
• W2771770396 cites W2531038644 @default.
• W2771770396 cites W2588245433 @default.
• W2771770396 cites W2594895540 @default.
• W2771770396 cites W2596463029 @default.
• W2771770396 cites W2742827968 @default.
• W2771770396 cites W2886334118 @default.
• W2771770396 cites W4230119926 @default.
• W2771770396 cites W96015874 @default.
• W2771770396 doi "https://doi.org/10.3389/fnins.2017.00651" @default.
• W2771770396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5717020" @default.
• W2771770396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29249928" @default.
• W2771770396 hasPublicationYear "2017" @default.
• W2771770396 type Work @default.

• next