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- W2771771111 abstract "The enzymes hydroxylamine oxidoreductase and cytochrome (cyt) P460 contain related unconventional heme P460 cofactors. These cofactors are unusual in their inclusion of nonstandard cross-links between amino acid side chains and the heme macrocycle. Mutagenesis studies performed on the Nitrosomonas europaea cyt P460 that remove its lysine-heme cross-link show that the cross-link is key to defining the spectroscopic properties and kinetic competence of the enzyme. However, exactly how this cross-link confers these features remains unclear. Here we report the 1.45 Å crystal structure of cyt P460 from Nitrosomonas sp. AL212 and conclude that the cross-link does not lead to a change in hybridization of the heme carbon participating in the cross-link but rather enforces structural distortions to the macrocycle away from planarity. Time-dependent density functional theory coupled to experimental structural and spectroscopic analysis suggest that this geometric distortion is sufficient to define the spectroscopic properties of the heme P460 cofactor and provide clues toward establishing a relationship between heme P460 electronic structure and function." @default.
- W2771771111 created "2017-12-22" @default.
- W2771771111 creator A5006857139 @default.
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- W2771771111 date "2017-12-06" @default.
- W2771771111 modified "2023-09-27" @default.
- W2771771111 title "The Eponymous Cofactors in Cytochrome P460s from Ammonia-Oxidizing Bacteria Are Iron Porphyrinoids Whose Macrocycles Are Dibasic" @default.
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- W2771771111 doi "https://doi.org/10.1021/acs.biochem.7b00921" @default.
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