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• W2771798413 endingPage "155" @default.
• W2771798413 startingPage "127" @default.
• W2771798413 abstract "Composite lymphomas are rare combinations of two distinct types of lymphomas occurring simultaneously in one patient, often a Hodgkin lymphoma (HL) and a non-Hodgkin lymphoma (NHL). In other instances, a HL and a NHL may occur subsequently in a patient. Some composite lymphomas likely represent chance occurrences of two independent tumors. However, in a large fraction of combined HL and NHL, the two lymphomas are clonally related and hence have a common origin. Detailed analysis of the rearranged immunoglobulin V region genes of such related lymphomas provided strong evidence that in many cases, the two lymphomas in composite as well as consecutive HL and B-cell NHL developed from distinct daughter cells of a mutating germinal center (GC) B-cell clone. Clonally related composite lymphomas carry both shared early genetic lesions as well as later separate transforming events, supporting a multi-step transformation process in such cases. The pattern of clonally related immunoglobulin V region genes and shared genetic lesions points to a close relationship of HL to B-cell NHL. Nodular lymphocyte predominant HL shows numerous histological and phenotypic similarities to follicular lymphoma. The tumor cells of both lymphomas represent transformed GC B cells, but the two lymphomas differ in their patterns of mutated oncogenes and tumor suppressor genes. The lymphomas most closely related to classical HL are primary mediastinal B-cell lymphoma (PMBL) and anaplastic large cell lymphoma (ALCL). Classical HL and PMBL share many constitutively activated signaling pathways and show a large overlap in their patterns of genetic lesions, but the lymphoma cells seem to derive from two distinct subsets of GC B cells. The lymphoma cells in cHL and ALCL also share a number of deregulated signaling pathways, as well as morphological and phenotypical features, but a major distinction is the B-cell derivation of classical HL and the T-cell origin of ALCL." @default.
• W2771798413 created "2017-12-22" @default.
• W2771798413 creator A5030177657 @default.
• W2771798413 creator A5091333429 @default.
• W2771798413 date "2017-10-06" @default.
• W2771798413 modified "2023-09-27" @default.
• W2771798413 title "Composite Lymphomas and the Relationship of Hodgkin Lymphoma to Non-Hodgkin Lymphomas" @default.
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