Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771808227> ?p ?o ?g. }
- W2771808227 endingPage "337" @default.
- W2771808227 startingPage "327" @default.
- W2771808227 abstract "A sperm-driven micromotor is presented as cargo-delivery system for the treatment of gynecological cancers. This particular hybrid micromotor is appealing to treat diseases in the female reproductive tract, the physiological environment that sperm cells are naturally adapted to swim in. Here, the single sperm cell serves as an active drug carrier and as driving force, taking advantage of its swimming capability, while a laser-printed microstructure coated with a nanometric layer of iron is used to guide and release the sperm in the desired area by an external magnet and structurally imposed mechanical actuation, respectively. The printed tubular microstructure features four arms which release the drug-loaded sperm cell in situ when they bend upon pushing against a tumor spheroid, resulting in the drug delivery, which occurs when the sperm squeezes through the cancer cells and fuses with cell membrane. Sperms also offer higher drug encapsulation capability and carrying stability compared to other nano and microcarriers, minimizing toxic effects and unwanted drug accumulation. Moreover, sperms neither express pathogenic proteins nor proliferate to form undesirable colonies, unlike other cells or microorganisms do, making this bio-hybrid system a unique and biocompatible cargo delivery platform for various biomedical applications, especially in gynecological healthcare." @default.
- W2771808227 created "2017-12-22" @default.
- W2771808227 creator A5021095562 @default.
- W2771808227 creator A5060029657 @default.
- W2771808227 creator A5061652666 @default.
- W2771808227 creator A5066535943 @default.
- W2771808227 creator A5089695277 @default.
- W2771808227 creator A5091075680 @default.
- W2771808227 date "2017-12-13" @default.
- W2771808227 modified "2023-10-11" @default.
- W2771808227 title "Sperm-Hybrid Micromotor for Targeted Drug Delivery" @default.
- W2771808227 cites W1543790510 @default.
- W2771808227 cites W154624432 @default.
- W2771808227 cites W1564553363 @default.
- W2771808227 cites W1850064990 @default.
- W2771808227 cites W1990017773 @default.
- W2771808227 cites W1992734626 @default.
- W2771808227 cites W1998936364 @default.
- W2771808227 cites W2008953890 @default.
- W2771808227 cites W2008988352 @default.
- W2771808227 cites W2011891975 @default.
- W2771808227 cites W2014705772 @default.
- W2771808227 cites W2021481379 @default.
- W2771808227 cites W2022027649 @default.
- W2771808227 cites W2022458258 @default.
- W2771808227 cites W2023520535 @default.
- W2771808227 cites W2024132288 @default.
- W2771808227 cites W2033412811 @default.
- W2771808227 cites W2039864751 @default.
- W2771808227 cites W2042297443 @default.
- W2771808227 cites W2054543474 @default.
- W2771808227 cites W2054739272 @default.
- W2771808227 cites W2063894880 @default.
- W2771808227 cites W2065597712 @default.
- W2771808227 cites W2071219385 @default.
- W2771808227 cites W2072233438 @default.
- W2771808227 cites W2076226743 @default.
- W2771808227 cites W2076619304 @default.
- W2771808227 cites W2077875823 @default.
- W2771808227 cites W2078064735 @default.
- W2771808227 cites W2080989041 @default.
- W2771808227 cites W2083355784 @default.
- W2771808227 cites W2088864569 @default.
- W2771808227 cites W2093410682 @default.
- W2771808227 cites W2102449174 @default.
- W2771808227 cites W2103140539 @default.
- W2771808227 cites W2107900012 @default.
- W2771808227 cites W2108572246 @default.
- W2771808227 cites W2109106144 @default.
- W2771808227 cites W2114235650 @default.
- W2771808227 cites W2123958837 @default.
- W2771808227 cites W2132057466 @default.
- W2771808227 cites W2134065925 @default.
- W2771808227 cites W2139702993 @default.
- W2771808227 cites W2143069923 @default.
- W2771808227 cites W2153882653 @default.
- W2771808227 cites W2160425601 @default.
- W2771808227 cites W2170663303 @default.
- W2771808227 cites W2183528114 @default.
- W2771808227 cites W2197016462 @default.
- W2771808227 cites W2234717249 @default.
- W2771808227 cites W2265524865 @default.
- W2771808227 cites W2313248184 @default.
- W2771808227 cites W2319080475 @default.
- W2771808227 cites W2396805552 @default.
- W2771808227 cites W2515051096 @default.
- W2771808227 cites W2515795587 @default.
- W2771808227 cites W2516658189 @default.
- W2771808227 cites W2549919366 @default.
- W2771808227 cites W2571334796 @default.
- W2771808227 cites W2596914826 @default.
- W2771808227 cites W2615064789 @default.
- W2771808227 cites W2742552651 @default.
- W2771808227 cites W4211003911 @default.
- W2771808227 doi "https://doi.org/10.1021/acsnano.7b06398" @default.
- W2771808227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29202221" @default.
- W2771808227 hasPublicationYear "2017" @default.
- W2771808227 type Work @default.
- W2771808227 sameAs 2771808227 @default.
- W2771808227 citedByCount "332" @default.
- W2771808227 countsByYear W27718082272017 @default.
- W2771808227 countsByYear W27718082272018 @default.
- W2771808227 countsByYear W27718082272019 @default.
- W2771808227 countsByYear W27718082272020 @default.
- W2771808227 countsByYear W27718082272021 @default.
- W2771808227 countsByYear W27718082272022 @default.
- W2771808227 countsByYear W27718082272023 @default.
- W2771808227 crossrefType "journal-article" @default.
- W2771808227 hasAuthorship W2771808227A5021095562 @default.
- W2771808227 hasAuthorship W2771808227A5060029657 @default.
- W2771808227 hasAuthorship W2771808227A5061652666 @default.
- W2771808227 hasAuthorship W2771808227A5066535943 @default.
- W2771808227 hasAuthorship W2771808227A5089695277 @default.
- W2771808227 hasAuthorship W2771808227A5091075680 @default.
- W2771808227 hasBestOaLocation W27718082271 @default.
- W2771808227 hasConcept C136229726 @default.
- W2771808227 hasConcept C1491633281 @default.
- W2771808227 hasConcept C171250308 @default.