FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2771811312> ?p ?o ?g. }

• W2771811312 endingPage "e0189181" @default.
• W2771811312 startingPage "e0189181" @default.
• W2771811312 abstract "Most seabirds do not have any outward identifiers of their chronological age, so estimation of seabird population age structure generally requires expensive, long-term banding studies. We investigated the potential to use a molecular age biomarker to estimate age in short-tailed shearwaters (Ardenna tenuirostris). We quantified DNA methylation in several A. tenuirostris genes that have shown age-related methylation changes in mammals. In birds ranging from chicks to 21 years of age, bisulphite treated blood and feather DNA was sequenced and methylation levels analysed in 67 CpG sites in 13 target gene regions. From blood samples, five of the top relationships with age were identified in KCNC3 loci (CpG66: R2 = 0.325, p = 0.019). In feather samples ELOVL2 (CpG42: R2 = 0.285, p = 0.00048) and EDARADD (CpG46: R2 = 0.168, p = 0.0067) were also weakly correlated with age. However, the majority of markers had no clear association with age (of 131 comparisons only 12 had a p-value < 0.05) and statistical analysis using a penalised lasso approach did not produce an accurate ageing model. Our data indicate that some age-related signatures identified in orthologous mammalian genes are not conserved in the long-lived short tailed shearwater. Alternative molecular approaches will be required to identify a reliable biomarker of chronological age in these seabirds." @default.
• W2771811312 created "2017-12-22" @default.
• W2771811312 creator A5004679491 @default.
• W2771811312 creator A5005524765 @default.
• W2771811312 creator A5014095375 @default.
• W2771811312 creator A5019223135 @default.
• W2771811312 creator A5076173418 @default.
• W2771811312 creator A5087288520 @default.
• W2771811312 creator A5090797394 @default.
• W2771811312 date "2017-12-07" @default.
• W2771811312 modified "2023-10-09" @default.
• W2771811312 title "DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird" @default.
• W2771811312 cites W1486360339 @default.
• W2771811312 cites W1597362049 @default.
• W2771811312 cites W1639076783 @default.
• W2771811312 cites W1692222554 @default.
• W2771811312 cites W1904700826 @default.
• W2771811312 cites W1967708893 @default.
• W2771811312 cites W1974047233 @default.
• W2771811312 cites W1975134670 @default.
• W2771811312 cites W1979750695 @default.
• W2771811312 cites W1980326316 @default.
• W2771811312 cites W1981243676 @default.
• W2771811312 cites W1984693806 @default.
• W2771811312 cites W2001825414 @default.
• W2771811312 cites W2003509608 @default.
• W2771811312 cites W2007695757 @default.
• W2771811312 cites W2017449797 @default.
• W2771811312 cites W2022922635 @default.
• W2771811312 cites W2023097783 @default.
• W2771811312 cites W2036284273 @default.
• W2771811312 cites W2039669402 @default.
• W2771811312 cites W2042160423 @default.
• W2771811312 cites W2048555293 @default.
• W2771811312 cites W2055043387 @default.
• W2771811312 cites W2057474608 @default.
• W2771811312 cites W2058409185 @default.
• W2771811312 cites W2059236074 @default.
• W2771811312 cites W2060573751 @default.
• W2771811312 cites W2060922712 @default.
• W2771811312 cites W2063307896 @default.
• W2771811312 cites W2073393965 @default.
• W2771811312 cites W2080094749 @default.
• W2771811312 cites W2080644309 @default.
• W2771811312 cites W2094579758 @default.
• W2771811312 cites W2095047324 @default.
• W2771811312 cites W2095359853 @default.
• W2771811312 cites W2096980369 @default.
• W2771811312 cites W2097360283 @default.
• W2771811312 cites W2097746267 @default.
• W2771811312 cites W2104751591 @default.
• W2771811312 cites W2105712810 @default.
• W2771811312 cites W2108443548 @default.
• W2771811312 cites W2110147508 @default.
• W2771811312 cites W2111775559 @default.
• W2771811312 cites W2115070756 @default.
• W2771811312 cites W2120048439 @default.
• W2771811312 cites W2121091193 @default.
• W2771811312 cites W2122678638 @default.
• W2771811312 cites W2123032740 @default.
• W2771811312 cites W2123406361 @default.
• W2771811312 cites W2124208364 @default.
• W2771811312 cites W2124351063 @default.
• W2771811312 cites W2128016314 @default.
• W2771811312 cites W2135144777 @default.
• W2771811312 cites W2136970997 @default.
• W2771811312 cites W2139122477 @default.
• W2771811312 cites W2146794662 @default.
• W2771811312 cites W2149585679 @default.
• W2771811312 cites W2149879655 @default.
• W2771811312 cites W2156815362 @default.
• W2771811312 cites W2161080415 @default.
• W2771811312 cites W2162098634 @default.
• W2771811312 cites W2163594555 @default.
• W2771811312 cites W2164718269 @default.
• W2771811312 cites W2168228291 @default.
• W2771811312 cites W2260295466 @default.
• W2771811312 cites W2320106101 @default.
• W2771811312 cites W2463513647 @default.
• W2771811312 cites W2552955852 @default.
• W2771811312 cites W4294541781 @default.
• W2771811312 cites W96545266 @default.
• W2771811312 doi "https://doi.org/10.1371/journal.pone.0189181" @default.
• W2771811312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5720723" @default.
• W2771811312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29216256" @default.
• W2771811312 hasPublicationYear "2017" @default.
• W2771811312 type Work @default.
• W2771811312 sameAs 2771811312 @default.
• W2771811312 citedByCount "6" @default.
• W2771811312 countsByYear W27718113122018 @default.
• W2771811312 countsByYear W27718113122019 @default.
• W2771811312 countsByYear W27718113122020 @default.
• W2771811312 countsByYear W27718113122021 @default.
• W2771811312 countsByYear W27718113122023 @default.
• W2771811312 crossrefType "journal-article" @default.
• W2771811312 hasAuthorship W2771811312A5004679491 @default.
• W2771811312 hasAuthorship W2771811312A5005524765 @default.
• W2771811312 hasAuthorship W2771811312A5014095375 @default.

• next