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- W2771844218 abstract "Background: Peritoneal dialysis after kidney transplant failure is not referred, because the risk of infection may increase due to the use of immunosuppressive agents. However, the precise association between steroid use and the risk of peritonitis remains elusive. Methods: 41 patients undergoing peritoneal dialysis after graft loss (DAGL) were recruited. The patients were divided according to the tertiles of the mean steroid dose (mg) or the tapering steroid regimen. The primary outcome such as the first episode of peritonitis was compared using Cox proportional hazard ratio (HR) analysis. Furthermore, the risk of peritonitis in the DAGL group was compared with that of 712 transplant-naïve (TN) patients. Results: The mean steroid doses were 0.3 mg, 2.3 mg, and 8.0 mg in the three tertiles. The 3rd tertile for the steroid dose had a greater risk of peritonitis than the 1st tertile (HR, 38.3 (3.9-376.7); P = 0.002). The tapering steroid regimen showed a significance as a predictive factor of peritonitis (HR, 6.0 (1.5-24.4); P = 0.013). The peritonitis risk of DAGL group was not different from that of TN group. However, the 3rd tertile for steroid dose had a greater HR than the TN group (HR, 3.0 (1.5-6.0); P = 0.001).Figure: No Caption available.The group with non-tapering steroid showed a slightly higher risk of peritonitis than the TN group: HR, 1.7 (0.9-3.0); P = 0.085Figure: No Caption available.Conclusions: The present study firstly identified the association between steroid use and peritonitis risk in peritoneal dialysis patients with kidney transplant failure. Tapering steroid may be needed to reduce the risk of peritonitis in this patient group." @default.
- W2771844218 created "2017-12-22" @default.
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- W2771844218 date "2014-07-01" @default.
- W2771844218 modified "2023-10-18" @default.
- W2771844218 title "Association Between Steroid Use and the Risk of Peritonitis in Patients With Peritoneal Dialysis After Kidney Transplant Failure." @default.
- W2771844218 doi "https://doi.org/10.1097/00007890-201407151-02097" @default.
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