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• W2771871188 abstract "Abstract Targeting protein degradation is recognized as a valid approach to cancer therapy. The ubiquitin–proteasome system (UPS) and the autophagy–lysosome pathway are two major pathways for intracellular protein degradation. Proteasome inhibitors such as bortezomib are clinically approved for treating malignancies, but to date, they are still unsatisfactory for cancer therapy. This study identifies titania‐coated gold nano‐bipyramid (NBP/TiO 2 ) nanostructures as an autophagic flux inhibitor, as the smallest NBP/TiO 2 nanostructures induce significant autophagosome accumulation in human glioblastoma U‐87 MG cells via blocking the autophagosome–lysosome fusion process and inhibiting lysosomal degradation. Further study indicates that NBP/TiO 2 nanostructures reduce the intracellular level of mature cathepsin B and directly inhibit the proteolytic activity of cathepsin B, thereby further inhibiting trypsin‐like proteolytic activity, which is a potential cotarget for UPS inhibition. NBP/TiO 2 nanostructures interact synergistically with bortezomib to suppress the viability of U‐87 MG cells, as the combined treatment synergistically induces the intracellular accumulation of ubiquitinated protein and endoplasmic reticulum stress. In addition, photothermal therapy further synergistically reduces the cell viability. In summary, this study suggests that NBP/TiO 2 nanostructures function as a promising anticancer agent in combination with proteasome inhibitors." @default.
• W2771871188 created "2017-12-22" @default.
• W2771871188 creator A5000570733 @default.
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• W2771871188 date "2017-12-01" @default.
• W2771871188 modified "2023-10-16" @default.
• W2771871188 title "Titania‐Coated Gold Nano‐Bipyramids for Blocking Autophagy Flux and Sensitizing Cancer Cells to Proteasome Inhibitor‐Induced Death" @default.
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• W2771871188 doi "https://doi.org/10.1002/advs.201700585" @default.
• W2771871188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5867123" @default.
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• W2771871188 hasPublicationYear "2017" @default.
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