FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W277187570> ?p ?o ?g. }

• W277187570 endingPage "8" @default.
• W277187570 startingPage "791" @default.
• W277187570 abstract "The mechanism of the anti-promoting effect of the prostaglandin (PG) synthesis inhibitor indomethacin in colon carcinogenesis was investigated. Male Sprague-Dawley rats received 0.002% water solution of indomethacin as drinking water freely for 3 days, then a subcutaneous injection of various doses of PGE2 and/or an intrarectal instillation of 12 mumol of sodium deoxycholate as a colon tumor promoter. Ornithine decarboxylase (ODC), a marker of tumor promotion, in the distal colonic mucosa was assayed at 4 hr after deoxycholate instillation. Indomethacin significantly suppressed the deoxycholate-augmented increase of ODC activity, while exogenous PGE2 restored or further increased the augmented ODC activity. The amount of PGE2 and the level of ODC activity were well correlated. However, PGE2 alone without deoxycholate did not increase the activity. Deoxycholate markedly increased colonic mucosal PGE2 at 1 hr after the instillation, and indomethacin decreased it. The results indicate that PGE2, the production of which is stimulated in the colonic mucosa by deoxycholate, is involved in the induction of colonic mucosal ODC. This is probably why PG synthesis inhibitors may inhibit the tumor promotion and prevent cancer development in the colon." @default.
• W277187570 created "2016-06-24" @default.
• W277187570 creator A5010659470 @default.
• W277187570 creator A5038378766 @default.
• W277187570 creator A5049423255 @default.
• W277187570 creator A5064049664 @default.
• W277187570 creator A5082920391 @default.
• W277187570 date "1987-08-01" @default.
• W277187570 modified "2023-09-23" @default.
• W277187570 title "Involvement of prostaglandin E2 in bile acid-caused promotion of colon carcinogenesis and anti-promotion by the cyclooxygenase inhibitor indomethacin." @default.
• W277187570 cites W143263338 @default.
• W277187570 cites W1531474138 @default.
• W277187570 cites W1556109257 @default.
• W277187570 cites W1894748892 @default.
• W277187570 cites W1972096233 @default.
• W277187570 cites W1977241907 @default.
• W277187570 cites W1995978700 @default.
• W277187570 cites W1999744724 @default.
• W277187570 cites W2018452213 @default.
• W277187570 cites W2026831500 @default.
• W277187570 cites W2029487918 @default.
• W277187570 cites W2032773367 @default.
• W277187570 cites W2038453831 @default.
• W277187570 cites W2046916308 @default.
• W277187570 cites W2048680569 @default.
• W277187570 cites W2057390688 @default.
• W277187570 cites W2060620278 @default.
• W277187570 cites W2069235266 @default.
• W277187570 cites W2078733037 @default.
• W277187570 cites W2085122834 @default.
• W277187570 cites W2087533996 @default.
• W277187570 cites W2099530054 @default.
• W277187570 cites W2115934424 @default.
• W277187570 cites W2138432364 @default.
• W277187570 cites W2139474049 @default.
• W277187570 cites W2151979934 @default.
• W277187570 cites W2166277258 @default.
• W277187570 cites W2167555569 @default.
• W277187570 cites W2193708708 @default.
• W277187570 cites W2271159090 @default.
• W277187570 cites W2281124822 @default.
• W277187570 cites W2316135868 @default.
• W277187570 cites W2347045468 @default.
• W277187570 cites W2410304956 @default.
• W277187570 cites W2460522821 @default.
• W277187570 cites W1524297452 @default.
• W277187570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3115924" @default.
• W277187570 hasPublicationYear "1987" @default.
• W277187570 type Work @default.
• W277187570 sameAs 277187570 @default.
• W277187570 citedByCount "20" @default.
• W277187570 countsByYear W2771875702015 @default.
• W277187570 crossrefType "journal-article" @default.
• W277187570 hasAuthorship W277187570A5010659470 @default.
• W277187570 hasAuthorship W277187570A5038378766 @default.
• W277187570 hasAuthorship W277187570A5049423255 @default.
• W277187570 hasAuthorship W277187570A5064049664 @default.
• W277187570 hasAuthorship W277187570A5082920391 @default.
• W277187570 hasConcept C121289238 @default.
• W277187570 hasConcept C121608353 @default.
• W277187570 hasConcept C126322002 @default.
• W277187570 hasConcept C134018914 @default.
• W277187570 hasConcept C181199279 @default.
• W277187570 hasConcept C185592680 @default.
• W277187570 hasConcept C2777956040 @default.
• W277187570 hasConcept C2779399885 @default.
• W277187570 hasConcept C2779689624 @default.
• W277187570 hasConcept C2780122803 @default.
• W277187570 hasConcept C2780664492 @default.
• W277187570 hasConcept C2780722877 @default.
• W277187570 hasConcept C2780749602 @default.
• W277187570 hasConcept C526805850 @default.
• W277187570 hasConcept C55493867 @default.
• W277187570 hasConcept C555283112 @default.
• W277187570 hasConcept C71924100 @default.
• W277187570 hasConcept C98274493 @default.
• W277187570 hasConceptScore W277187570C121289238 @default.
• W277187570 hasConceptScore W277187570C121608353 @default.
• W277187570 hasConceptScore W277187570C126322002 @default.
• W277187570 hasConceptScore W277187570C134018914 @default.
• W277187570 hasConceptScore W277187570C181199279 @default.
• W277187570 hasConceptScore W277187570C185592680 @default.
• W277187570 hasConceptScore W277187570C2777956040 @default.
• W277187570 hasConceptScore W277187570C2779399885 @default.
• W277187570 hasConceptScore W277187570C2779689624 @default.
• W277187570 hasConceptScore W277187570C2780122803 @default.
• W277187570 hasConceptScore W277187570C2780664492 @default.
• W277187570 hasConceptScore W277187570C2780722877 @default.
• W277187570 hasConceptScore W277187570C2780749602 @default.
• W277187570 hasConceptScore W277187570C526805850 @default.
• W277187570 hasConceptScore W277187570C55493867 @default.
• W277187570 hasConceptScore W277187570C555283112 @default.
• W277187570 hasConceptScore W277187570C71924100 @default.
• W277187570 hasConceptScore W277187570C98274493 @default.
• W277187570 hasIssue "8" @default.
• W277187570 hasLocation W2771875701 @default.
• W277187570 hasOpenAccess W277187570 @default.
• W277187570 hasPrimaryLocation W2771875701 @default.

• next