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• W2771904858 startingPage "473" @default.
• W2771904858 abstract "The aim of this study is to analyze whether clozapine serum concentration may affect fasting serum levels of several appetite regulating peptides: CART, PYY(1-36), NPY, AgRP, des-acylated ghrelin, leptin and obestatin. Serum concentration of clozapine and fasting serum levels of des-acylated ghrelin, neuropeptide Y (NPY), agouti-related protein (AgRP), peptide YY (PYY(1-36)), cocaine- and amphetamine-regulated transcript (CART), leptin and obestatin were measured in 30 subjects with schizophrenia on clozapine monotherapy. Leptin concentration was negatively correlated with clozapine dose (r = −0.53, p = 0.002), while NPY concentration was negatively correlated with clozapine concentration (r = −0.55, p = 0.01). Correlations with other peptides were not significant. We cannot conclude that serum concentration of clozapine is directly associated with increased or decreased level of appetite-regulating peptides." @default.
• W2771904858 created "2017-12-22" @default.
• W2771904858 creator A5055572738 @default.
• W2771904858 creator A5078232203 @default.
• W2771904858 creator A5083875162 @default.
• W2771904858 date "2018-02-01" @default.
• W2771904858 modified "2023-10-01" @default.
• W2771904858 title "Effect of clozapine dose and concentration on fasting concentration of appetite regulating peptides" @default.
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• W2771904858 doi "https://doi.org/10.1016/j.psychres.2017.12.018" @default.
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• W2771904858 hasPublicationYear "2018" @default.
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